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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MST1 | 4485 | Macrophage stimulating 1 (hepatocyte growth factor-like) | 3 | MSP; HGFL; NF15S2; D3F15S2; DNF15S2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17277767 | 2007 | Cell line : - Source : Institute of Pathology, University Hospital of Basel, Switzerland, the Institute of Clinical Pathology, Basel, Switzerland and the Institute of Pathology, Stadtspital Triemli, Zurich, Switzerland. Sample Type : Case control study No. of Sample : 1420 unselected, non-consecutive colorectal cancers Stage : - | Microarray technology, Immunohistochemistry, methylation-specific PCR and Bisulphite Modification | Down-regulation | - | Loss of cytoplasmic Mst1 was associated with higher T stage, higher N stage, vascular invasion and overall survival. Can be used as prognostic marker. |
| 21233674 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 221 Stage : - | Multiple-punch tissue microarray, Multivariate analysis | Down-regulation | - | Node positive cancers showed significant losses for cytoplasmic MST1 along with other genes. |
| 22614045 | 2012 | Cell line : - Source : - Sample Type : Serum sample No. of Sample : 99 serum samples from 73 CRC patients and 26 healthy controls Stage : - | HPLC and MALDI-TOF-MS | Down-regulation | - | 3.9-kDa a fragment of serine/theonine kinase 4 (MST1/STK4) which concentration in the serum of the CRC patients was much lower than that in the healthy controls. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010] |
| Chromosome | 3 |
| Location | 3p21 |
| Start | 49683947 |
| End | 49689528 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5582 |
| OMIM ID | 142408 |
| HGNC ID | HGNC:7380 |
| Unigene ID | Hs.349110 |
| Ensembl ID | ENSG00000173531 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_006713166.1 |
|---|---|
| Exon | join(1..931,1632..1779,1861..1973,2051..2165,2244..2380, 2462..2578,2727..2845,3048..3216,3567..3669,3797..3933, 4023..4058,4147..4267,4440..4517,4645..4791,4873..4979, 5076..5215,5340..5582) | mRNA Sequence | Download Select all |
| Length | 2348 |
CDS Information
| Location | join(838..931,1632..1779,1861..1973,2051..2165,2244..2380, 2462..2578,2727..2845,3048..3216,3567..3669,3797..3933, 4023..4058,4147..4267,4440..4517,4645..4791,4873..4979, 5076..5215,5340..5501) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_066278.3 |
|---|---|
| Protein Name | Macrophage stimulating 1 (hepatocyte growth factor-like) |
| Molecular Wt. (Da) | 78414 |
| Protein Sequence | Download Select all |
| Length | 725 |
| Uniprot ID | Q14002 |
| Ensembl Protein ID | ENSP00000006724 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 310 |
| C | Disulfide Bridge | 541;576 |
| C | Disulfide Bridge | 602;686 |
| N | Glycosylation | 629 |
| N | Glycosylation | 86 |
| R | Proteolytic Cleavage | 497 |
Enzyme Information
| EC | 2.3.1.48 |
|---|---|
| Name | histone acetyltransferase nucleosome-histone acetyltransferase histone acetokinase histone acetylase histone transacetylase |
| Class | Transferases; Acyltransferases; Transferring groups other than aminoacyl groups |
| Sysname | acetyl-CoA:histone acetyltransferase |
| Substrate | acetyl-CoA [CPD:C00024]; histone |
| Product | CoA [CPD:C00010]; acetylhistone |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 12 | SERPINA3 | 120 | NP_001076.2 | in vitro | 11274154 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 2ASU |
|---|---|
| Resolution | 1.85 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | Hepatocyte growth factor-like protein |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 484-707 | Tryp_SPc |
| cl21584 | 484-707 | Tryp_SPc superfamily |
| cd00108 | 368-449 | KR |
| cl00100 | 368-449 | KR superfamily |
| cd00108 | 188-268 | KR |
| cl00100 | 188-268 | KR superfamily |
| cd00108 | 108-186 | KR |
| cl00100 | 108-186 | KR superfamily |
| cd00108 | 280-361 | KR |
| cl00100 | 280-361 | KR superfamily |
| cd01099 | 23-104 | PAN_AP_HGF |
| cl00112 | 23-104 | PAN_APPLE superfamily |
| smart00130 | 368-450 | KR |
| smart00130 | 191-270 | KR |
| pfam00051 | 191-268 | Kringle |
| smart00130 | 108-188 | KR |
| pfam00051 | 283-361 | Kringle |
| smart00130 | 283-363 | KR |
| pfam00051 | 370-448 | Kringle |
| pfam00051 | 110-186 | Kringle |
| pfam00024 | 25-103 | PAN_1 |
| smart00473 | 24-104 | PAN_AP |
| smart00020 | 483-704 | Tryp_SPc |
| pfam00089 | 484-704 | Trypsin |
| COG5640 | 483-708 | COG5640 |
Ontology Information
| HPRD ID | 9071 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.