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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MTRR 4552 5-methyltetrahydrofolate-homocysteine methyltransferase reductase  5cblE 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26214647   2015Cell line : -

Source : MEDLINE, EMBASE and ISI Web of knowledge, China National Knowledge Infrastructure (CNKI) and Wanfang Database

Sample Type : Population basedcase control study

No. of Sample : 6020 cases and 8317 controls

Stage : -

Meta analysisPolymorhpism- Data suggest an association between MTRR A66G polymorphism and CRC susceptibility among Caucasians.


Gene Details



NC_000005.9 (7851299..7901237)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]  
Chromosome 5
Location 5p15.31
Start 7851299  
End 7901237  
Strand +  
Gene Sequence

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Length 49939  
OMIM ID 602568   
HGNC ID HGNC:7473   
Unigene ID Hs.481551   
Ensembl ID ENSG00000124275   
PharmGKB ID PA31277   

mRNA Information


mRNA ID NM_001089584.2
Exon complement(<1..305)  
mRNA Sequence

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Length 2460  



CDS Information


   
Location 470..913
CDS Sequence

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CCDS ID CCDS3874.1



Protein Information


      
Protein IDNP_001083053.1
Protein Name5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Molecular Wt. (Da)0
Protein Sequence

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Length 147  
Uniprot IDP33981
Ensembl Protein ID ENSP00000230510  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation183
SPhosphorylation156
SPhosphorylation184
SPhosphorylation157
SPhosphorylation198
SPhosphorylation171

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
326625MMAB7398NP_443077.1in vitro15347655   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06203304-724  methionine_synthase_red
cl06868304-724  FNR_like superfamily
cd06204296-724  CYPOR
cd06182463-724  CYPOR_like
cd06207304-724  CyPoR_like
cd06202310-723  Nitric_oxide_synthase
cd06199310-724  SiR
cd06206331-724  bifunctional_CYPOR
pfam00667296-519  FAD_binding_1
cl19189296-519  FAD_binding_1 superfamily
pfam0025833-169  Flavodoxin_1
cl0043833-169  FMN_red superfamily
cd00322465-694  FNR_like
cd06200468-724  SiR_like1
cd06208477-719  CYPOR_like_FNR
cd06201477-724  SiR_like2
pfam00175569-689  NAD_binding_1
PRK0810528-177  PRK08105
PRK0900440-153  PRK09004
COG071628-147  FldA
PRK0572380-178  PRK05723
TIGR0175332-147  flav_short
cd06195465-693  FNR1
PRK0926728-148  PRK09267
TIGR0175233-189  flav_long
cd06196573-703  FNR_like_1
pfam1272432-144  Flavodoxin_5
PRK0670328-153  PRK06703
cd06184557-703  flavohem_like_fad_nad_binding
cd06209556-678  BenDO_FAD_NAD
cd06194555-680  FNR_N-term_Iron_sulfur_binding
cd06198561-691  FNR_like_3
PRK0730833-167  PRK07308
cd06189556-693  flavin_oxioreductase
cd06187556-691  O2ase_reductase_like
cd06217556-692  FNR_iron_sulfur_binding_3
COG463530-114  HemG
cd06216557-678  FNR_iron_sulfur_binding_2
TIGR0175430-149  flav_RNR
cd06183567-678  cyt_b5_reduct_like
COG036926-724  CysJ
TIGR0193129-724  cysJ
PRK06214311-724  PRK06214
PRK1095333-724  cysJ
PLN03116559-708  PLN03116
PLN03115478-710  PLN03115
TIGR03224556-694  benzo_boxA
COG1018554-694  Fpr
COG0543471-693  Mcr1
PRK08345567-639  PRK08345
PRK07609556-615  PRK07609


Ontology Information


   
HPRD ID3861
Molecular ClassEnzyme: Oxidoreductase
Molecular FunctionTranslation regulator activity (GO:0045182)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q9UBK8DB00115CyanocobalaminSmallMoleculeDrug
Q9UBK8DB00134L-MethionineSmallMoleculeDrug
Q9UBK8DB00200HydroxocobalaminSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO