Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MUC2 | 4583 | Mucin 2, oligomeric mucus/gel-forming  | 11 | MLP; SMUC; MUC-2  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989    | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Down-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. |
| 23179399    | 2013 | Cell line : - Source : Turku University Hospital (TUH, Finland) Sample Type : CRC tumor and normal tissue No. of Sample : 141 Stage : TNM Stage I-IV | Tissue microarray and immunohistochemistry | Down-regulation | - | Loss of MUC2 expression may be associated with disease recurrence and worse survival in CRC. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Mucins |
| Description | This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]   |
| Chromosome | 11 |
| Location | 11p15.5 |
| Start | 1074875   |
| End | 1110508   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 35634   |
| OMIM ID | 158370    |
| HGNC ID | HGNC:7512    |
| Unigene ID | Hs.315    |
| Ensembl ID | ENSG00000198788    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_002457.3 |
|---|---|
| Exon | join(1..103,777..1047,2580..2694,3078..3168,3249..3358, 3438..3648,6788..6913,7411..7528,7607..7745,8004..8114, 8203..8272,8551..8688,8779..8943,9417..9511,9718..9844, 10194..10449,10680..10732,10871..10971,11372..11523, 11861..11999,12881..12991,13073..13252,13384..13623, 14635..14791,15068..15199,15890..16037,17525..17568, 17970..18173,18660..18677,19268..20193,20197..24886, 24899..25151,25883..26080,26349..26572,26882..27056, 27543..27790,28400..28583,28907..29135,29859..30037, 30429..30498,30637..30737,30982..31013,32212..32389, 32776..32880,33130..33170,33299..33421,33674..33772, 34407..34535,34773..34812,35027..35153,35262..35634)   | mRNA Sequence |    Download   Select all |
| Length | 15728   |
CDS Information
| Location | join(28..103,777..1047,2580..2694,3078..3168,3249..3358, 3438..3648,6788..6913,7411..7528,7607..7745,8004..8114, 8203..8272,8551..8688,8779..8943,9417..9511,9718..9844, 10194..10449,10680..10732,10871..10971,11372..11523, 11861..11999,12881..12991,13073..13252,13384..13623, 14635..14791,15068..15199,15890..16037,17525..17568, 17970..18173,18660..18677,19268..20193,20197. |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_002448.3 |
|---|---|
| Protein Name | Mucin 2, oligomeric mucus/gel-forming |
| Molecular Wt. (Da) | 538302 |
| Protein Sequence |    Download   Select all |
| Length | 5179   |
| Uniprot ID | O14646 |    
| Ensembl Protein ID | ENSP00000284049   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 4486 |
| S | Phosphorylation | 660 |
| Y | Phosphorylation | 669 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 9842 |    PLEKHM1 |    11439 |    NP_055613.1 |    in vitro |    12820725    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amoebiasis |    hsa05146 |    
| Vibrio cholerae infection |    hsa05110 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00216 | 849-1008  | VWD |
| cl02516 | 849-1008  | VWD superfamily |
| smart00216 | 4471-4638  | VWD |
| cl02516 | 4471-4638  | VWD superfamily |
| smart00216 | 380-544  | VWD |
| cl02516 | 380-544  | VWD superfamily |
| pfam00094 | 860-1009  | VWD |
| pfam00094 | 4481-4639  | VWD |
| pfam00094 | 391-544  | VWD |
| smart00216 | 36-185  | VWD |
| cl02516 | 36-185  | VWD superfamily |
| pfam00094 | 37-186  | VWD |
| smart00832 | 582-652  | C8 |
| cl07383 | 582-652  | C8 superfamily |
| pfam08742 | 1045-1118  | C8 |
| cl07383 | 1045-1118  | C8 superfamily |
| smart00832 | 1046-1118  | C8 |
| pfam00007 | 5072-5175  | Cys_knot |
| cl21545 | 5072-5175  | GHB_like superfamily |
| pfam08742 | 581-652  | C8 |
| pfam13330 | 1305-1388  | Mucin2_WxxW |
| cl16239 | 1305-1388  | Mucin2_WxxW superfamily |
| smart00041 | 5077-5157  | CT |
| pfam08742 | 4687-4754  | C8 |
| cl07383 | 4687-4754  | C8 superfamily |
| pfam08742 | 227-292  | C8 |
| cl07383 | 227-292  | C8 superfamily |
| pfam13330 | 1787-1875  | Mucin2_WxxW |
| cl16239 | 1787-1875  | Mucin2_WxxW superfamily |
| smart00832 | 4693-4754  | C8 |
| smart00832 | 234-292  | C8 |
| pfam01826 | 295-351  | TIL |
| cl20226 | 295-351  | TIL superfamily |
| smart00214 | 4926-4990  | VWC |
| cl17735 | 4926-4990  | VWC superfamily |
| pfam03045 | 5075-5155  | DAN |
Ontology Information
| HPRD ID | 4472 |    
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q02817 | DB01411 | Pranlukast | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
