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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MUC2 4583 Mucin 2, oligomeric mucus/gel-forming  11MLP; SMUC; MUC-2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysis Down-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.

23179399   2013Cell line : -

Source : Turku University Hospital (TUH, Finland)

Sample Type : CRC tumor and normal tissue

No. of Sample : 141

Stage : TNM Stage I-IV

Tissue microarray and immunohistochemistryDown-regulation-Loss of MUC2 expression may be associated with disease recurrence and worse survival in CRC.


Gene Details



Chromosome: 11; NC_000011.9 (1074875..1104417)

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Gene Type protein coding
Gene Family Mucins
Description This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]  
Chromosome 11
Location 11p15.5
Start 1074875  
End 1110508  
Strand +  
Gene Sequence

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Length 35634  
OMIM ID 158370   
HGNC ID HGNC:7512   
Unigene ID Hs.315   
Ensembl ID ENSG00000198788   
PharmGKB ID -   

mRNA Information


mRNA ID NM_002457.3
Exon join(1..103,777..1047,2580..2694,3078..3168,3249..3358, 3438..3648,6788..6913,7411..7528,7607..7745,8004..8114, 8203..8272,8551..8688,8779..8943,9417..9511,9718..9844, 10194..10449,10680..10732,10871..10971,11372..11523, 11861..11999,12881..12991,13073..13252,13384..13623, 14635..14791,15068..15199,15890..16037,17525..17568, 17970..18173,18660..18677,19268..20193,20197..24886, 24899..25151,25883..26080,26349..26572,26882..27056, 27543..27790,28400..28583,28907..29135,29859..30037, 30429..30498,30637..30737,30982..31013,32212..32389, 32776..32880,33130..33170,33299..33421,33674..33772, 34407..34535,34773..34812,35027..35153,35262..35634)  
mRNA Sequence

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Length 15728  



CDS Information


   
Location join(28..103,777..1047,2580..2694,3078..3168,3249..3358, 3438..3648,6788..6913,7411..7528,7607..7745,8004..8114, 8203..8272,8551..8688,8779..8943,9417..9511,9718..9844, 10194..10449,10680..10732,10871..10971,11372..11523, 11861..11999,12881..12991,13073..13252,13384..13623, 14635..14791,15068..15199,15890..16037,17525..17568, 17970..18173,18660..18677,19268..20193,20197.
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_002448.3
Protein NameMucin 2, oligomeric mucus/gel-forming
Molecular Wt. (Da)538302
Protein Sequence

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Length 5179  
Uniprot IDO14646
Ensembl Protein ID ENSP00000284049  



Post-translational Modification Information (Source : HPRD)


Residue Type site
DProteolytic Cleavage4486
SPhosphorylation660
YPhosphorylation669

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
9842PLEKHM111439NP_055613.1in vitro12820725   


Pathway Information


            
Pathway Name Pathway ID
Amoebiasis hsa05146
Vibrio cholerae infection hsa05110


Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart00216849-1008  VWD
cl02516849-1008  VWD superfamily
smart002164471-4638  VWD
cl025164471-4638  VWD superfamily
smart00216380-544  VWD
cl02516380-544  VWD superfamily
pfam00094860-1009  VWD
pfam000944481-4639  VWD
pfam00094391-544  VWD
smart0021636-185  VWD
cl0251636-185  VWD superfamily
pfam0009437-186  VWD
smart00832582-652  C8
cl07383582-652  C8 superfamily
pfam087421045-1118  C8
cl073831045-1118  C8 superfamily
smart008321046-1118  C8
pfam000075072-5175  Cys_knot
cl215455072-5175  GHB_like superfamily
pfam08742581-652  C8
pfam133301305-1388  Mucin2_WxxW
cl162391305-1388  Mucin2_WxxW superfamily
smart000415077-5157  CT
pfam087424687-4754  C8
cl073834687-4754  C8 superfamily
pfam08742227-292  C8
cl07383227-292  C8 superfamily
pfam133301787-1875  Mucin2_WxxW
cl162391787-1875  Mucin2_WxxW superfamily
smart008324693-4754  C8
smart00832234-292  C8
pfam01826295-351  TIL
cl20226295-351  TIL superfamily
smart002144926-4990  VWC
cl177354926-4990  VWC superfamily
pfam030455075-5155  DAN


Ontology Information


   
HPRD ID4472
Molecular ClassSecreted polypeptide
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q02817DB01411PranlukastSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO