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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MUC4 4585 mucin 4, cell surface associated  3- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20564074   2010Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 132

Stage : -

Univariate Kaplan-Meier and multivariate Cox regression methodsUp-regulation-Increased MUC4 expression is a predictor of poor survival in CRC, specifically for patients who have early stage tumors.

25124610   2014Cell line : LoVo, HCT 116

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR, Western blotting and dual-luciferase 3' UTR reporter assayUp-regulation-miR-150-5p may suppress CRC metastasis through directly targeting MUC4, highlighting its potential as a novel agent for the treatment of CRC metastasis.


Gene Details



NC_000003.11 (195473636..195539148, complement)

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Gene Type protein coding
Gene Family Mucins
Description The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]  
Chromosome 3
Location 3q29
Start 195473636  
End 195539148  
Strand -  
Gene Sequence

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Length 65513  
OMIM ID 158372   
HGNC ID HGNC:7514   
Unigene ID Hs.369646   
Ensembl ID ENSG00000145113   
PharmGKB ID PA31319   

mRNA Information


mRNA ID NM_138297.4
Exon join(1..238,37669..37802,40158..40322,41603..41758, 42822..42952,45223..45311,46525..46704,46852..46977, 47810..47929,48333..48541,49029..49119,49720..49887, 50389..50490,50857..51090,52713..52850,54646..54827, 57602..57761,58744..58923,59528..59601,60703..60767, 60862..61085,62910..63072,64594..65209)  
mRNA Sequence

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Length 3958  



CDS Information


   
Location 157..3534
CDS Sequence

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CCDS ID CCDS3310.1



Protein Information


      
Protein IDNP_612154.2
Protein Namemucin 4, cell surface associated
Molecular Wt. (Da)582674
Protein Sequence

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Length 1125  
Uniprot IDP02766
Ensembl Protein ID ENSP00000237014  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TGlycosylation4239

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2064ERBB21281NP_004439.2in vivo124   343   091   168   751   000   000   000   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart005391154-1311  NIDO
cl026481154-1311  NIDO superfamily
pfam037821313-1425  AMOP
cl027581313-1425  AMOP superfamily
smart007231310-1425  AMOP
smart002161430-1610  VWD
cl025161430-1610  VWD superfamily
pfam061191225-1309  NIDO
pfam000941440-1611  VWD
pfam05904489-847  DUF863
cl12320489-847  DUF863 superfamily
pfam0510923-319  Herpes_BLLF1
pfam05109662-1053  Herpes_BLLF1
PHA03307524-967  PHA03307
pfam05109488-833  Herpes_BLLF1
pfam05109599-970  Herpes_BLLF1
pfam0510985-517  Herpes_BLLF1
pfam05109458-885  Herpes_BLLF1
PHA03247633-1068  PHA03247
pfam0510929-380  Herpes_BLLF1
pfam05109303-702  Herpes_BLLF1
PRK07764632-945  PRK07764
PRK04654609-753  PRK04654
pfam03154519-1062  Atrophin-1
pfam06070612-1040  Herpes_UL32
PRK12799607-732  motB
PHA03247511-823  PHA03247
PRK12495751-853  PRK12495
COG5422744-998  ROM1
PRK13335563-699  PRK13335
PRK0858133-328  PRK08581
PRK1391438-162  PRK13914
PHA03307706-1064  PHA03307
PLN03209523-759  PLN03209
PRK13914563-835  PRK13914
COG5422536-810  ROM1
PRK13108663-841  PRK13108
COG3889113-240  COG3889
PHA0325545-230  PHA03255
PHA03247494-958  PHA03247
PRK11907761-864  PRK11907
pfam05642596-862  Sporozoite_P67
PHA03255204-362  PHA03255
PHA02584164-455  34
pfam15308620-950  CEP170_C
PHA03273143-241  PHA03273
PLN02217748-856  PLN02217
COG5422141-387  ROM1
PHA03255507-656  PHA03255
TIGR0092723-320  2A1904
PRK12799663-791  motB
pfam15449510-815  Retinal
pfam05642782-983  Sporozoite_P67
COG5099344-756  COG5099
PHA03255730-882  PHA03255
PRK13914609-858  PRK13914


Ontology Information


   
HPRD ID1761
Molecular ClassIntegral membrane protein
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO