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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MUC6 4588 mucin 6, oligomeric mucus/gel-forming  11- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23807779   2013Cell line : -

Source : Melbourne Collaborative Cohort Study

Sample Type : CRC tumor and normal tissues

No. of Sample : 722

Stage : -

-Up-regulation- MUC2 overexpression (>25% positive tumor cells) was observed in 33% colorectal cancers, MUC5B expression in 53%, and de novo MUC5AC and MUC6 expression in 50% and 39%, respectively.


Gene Details



NC_000011.9 (1012824..1036706, complement)

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Gene Type protein coding
Gene Family Mucins
Description The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al., 1993 [PubMed 7680650]).[supplied by OMIM, Dec 2010]  
Chromosome 11
Location 11p15.5
Start 1012824  
End 1036706  
Strand -  
Gene Sequence

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Length 23883  
OMIM ID 158374   
HGNC ID HGNC:7517   
Unigene ID Hs.528432   
Ensembl ID ENSG00000184956   
PharmGKB ID -   

mRNA Information


mRNA ID NM_005961.2
Exon join(1..103,3632..3694,4654..4894,4974..5100,5448..5538, 5651..5760,5927..6134,6372..6494,7092..7212,7341..7479, 7557..7661,7746..7818,7924..8061,8320..8481,8648..8742, 8890..9022,9190..9439,9514..9566,9657..9766,10229..10380, 10566..10707,10792..10902,11340..11525,11624..11863, 12604..12760,13055..13198,15430..15492,15973..16023, 16450..16617,17211..17432,17937..20945,22706..22808, 23074..23883)  
mRNA Sequence

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Length 8003  



CDS Information


   
Location 52..7371
CDS Sequence

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CCDS ID CCDS44513.1



Protein Information


      
Protein IDNP_005952.2
Protein Namemucin 6, oligomeric mucus/gel-forming
Molecular Wt. (Da)85344
Protein Sequence

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Length 2439  
Uniprot IDQ15672
Ensembl Protein ID ENSP00000242261  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
7031TFF1219NP_003216.1in vitro10673290   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart00216856-1017  VWD
cl02516856-1017  VWD superfamily
smart00216386-549  VWD
cl02516386-549  VWD superfamily
pfam00094397-550  VWD
pfam00094868-1017  VWD
pfam087421055-1128  C8
cl073831055-1128  C8 superfamily
smart0021640-192  VWD
cl0251640-192  VWD superfamily
smart008321056-1128  C8
pfam0009445-193  VWD
pfam08742588-660  C8
cl07383588-660  C8 superfamily
smart00832588-660  C8
pfam01826302-357  TIL
cl20226302-357  TIL superfamily
smart000412351-2434  CT
cl215452351-2434  GHB_like superfamily
pfam08742230-298  C8
cl07383230-298  C8 superfamily
pfam01826782-827  TIL
cl20226782-827  TIL superfamily
smart00832245-297  C8
smart00215359-403  VWC_out
cl17735359-403  VWC superfamily
pfam01826664-721  TIL
cl20226664-721  TIL superfamily
smart00215829-886  VWC_out
cl17735829-886  VWC superfamily
pfam051091625-1962  Herpes_BLLF1
pfam051091235-1577  Herpes_BLLF1
PHA032471215-1479  PHA03247
PHA032471203-1646  PHA03247
pfam051091660-2019  Herpes_BLLF1
pfam031541352-1631  Atrophin-1
pfam051091414-1739  Herpes_BLLF1
pfam051091259-1630  Herpes_BLLF1
PRK127991895-2015  motB
PHA033071334-1590  PHA03307
pfam051091498-1857  Herpes_BLLF1
PHA032471771-2010  PHA03247
PHA032552188-2343  PHA03255
TIGR006011940-2020  rad23
PRK077641237-1449  PRK07764
pfam154021234-1315  Spc7_N
PHA033781214-1460  PHA03378
pfam154021884-2020  Spc7_N
PTZ004491269-1579  PTZ00449
pfam051091417-1807  Herpes_BLLF1


Ontology Information


   
HPRD ID1490
Molecular ClassSecreted polypeptide
Molecular FunctionProtein-tyrosine kinase activity (GO:0004713)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO