Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GADD45B | 4616 | growth arrest and DNA-damage-inducible, beta | 19 | GADD45BETA, DKFZP566B133 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23110778 | 2012 | Cell line : LoVo, SW620, SW480 Source : ATCC, Fudan University Shanghai Cancer Center Sample Type : Formalin-fixed paraffin-embedded No. of Sample : - Stage : - | Immunohistochemistry,real time RT-PCR,SiRNA synthesis,Cell apoptosis analysis,Western blotting | Up-regulation | - | GADD45B could be a potential therapeutic target for CRC treatment in future. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19p13.3 |
| Start | 2476123 |
| End | 2478257 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2135 |
| OMIM ID | 604948 |
| HGNC ID | HGNC:4096 |
| Unigene ID | Hs.110571 |
| Ensembl ID | ENSG00000099860 |
| PharmGKB ID | PA28511 |
mRNA Information
| mRNA ID | NM_015675.3 |
|---|---|
| Exon | join(1..278,405..506,905..1127,1364..2135) | mRNA Sequence | Download Select all |
| Length | 1393 |
Protein Information
| Protein ID | NP_056490.2 |
|---|---|
| Protein Name | growth arrest and DNA-damage-inducible, beta |
| Molecular Wt. (Da) | 37590 |
| Protein Sequence | Download Select all |
| Length | 160 |
| Uniprot ID | P17480 |
| Ensembl Protein ID | ENSP00000302640 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 891 | CCNB1 | 454 | NP_114172.1 | in vitro;in vivo | 12124778 |
| 983 | CDK1 | 302 | NP_001777.1 | in vivo | 10973963 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vitro | 8700517 |
| 2099 | ESR1 | 589 | NP_000116.2 | in vitro | 10872826 |
| 4216 | MAP3K4 | 3886 | NP_005913.2 | in vitro;in vivo;yeast 2-hybrid | 982 780 414 743 220 |
| 4217 | MAP3K5 | 3904 | NP_005914.1 | in vitro | 14743220 |
| 5111 | PCNA | 1456 | NP_002583.1 | in vitro;in vivo;yeast 2-hybrid | 10828065 |
| 5465 | PPARA | 1369 | NP_001001930.1 | in vitro | 10872826 |
| 5467 | PPARD | 2679 | NP_006229.1 | in vitro | 10872826 |
| 5468 | PPARG | 3288 | NP_056953.2 | in vitro | 10872826 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| FoxO signaling pathway | hsa04068 |
| MAPK signaling pathway | hsa04010 |
| NF-kappa B signaling pathway | hsa04064 |
| p53 signaling pathway | hsa04115 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01248 | 21-120 | Ribosomal_L7Ae |
| cl00600 | 21-120 | Ribosomal_L7Ae superfamily |
Ontology Information
| HPRD ID | 3410 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.