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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ACLY 47 ATP citrate lyase  17ATPCL, CLATP, ACL 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25890184   2015Cell line : HT29

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Genotyping, Multivariate Cox regression analysis,Kaplan-Meier analysisPolymorhpism-The SNPs in ACLY gene may serve as independent prognostic markers for patients with advanced stage CRC. In patients with stage III + IV diseases, the two functional SNPs (rs2304497 and rs9912300) exhibited a significant association with the risks of death, respectively and recurrence.

24132143   2013Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 697

Stage : TNM Stage III,IV.

Flow Cytometry,Spectrophotometric Assay,MTT Assay,Western BlottingUp-regulation-Activations of the ACLy and AKT pathways play critical roles in CRC cell resistance to SN38.


Gene Details



NC_000017.10 (40023169..40086795, complement)

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Gene Type protein coding
Gene Family
Description ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]  
Chromosome 17
Location 17q21.2
Start 40023169  
End 40086795  
Strand -  
Gene Sequence

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Length 63627  
OMIM ID 108728   
HGNC ID HGNC:115   
Unigene ID Hs.387567   
Ensembl ID ENSG00000131473   
PharmGKB ID PA24441   

mRNA Information


mRNA ID XM_005257395.1
Exon join(1..185,16643..16828,18001..18123,20259..20321, 20843..21033,21475..21554,22971..23101,23897..24015, 24885..25021,25753..25814,28730..28847,31758..31912, 32704..32794,33894..33923,37369..37510,38096..38264, 42840..42944,44235..44431,46269..46350,47311..47421, 51619..51746,52347..52440,56578..56732,58361..58511, 58711..58854,60956..61069,61418..61500,61758..61834, 62639..63627)  
mRNA Sequence

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Length 4412  



CDS Information


   
Location 213..3518
CDS Sequence

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CCDS ID CCDS11412.1



Protein Information


      
Protein IDXP_005257452.1
Protein NameATP citrate lyase
Molecular Wt. (Da)120709
Protein Sequence

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Length 1101  
Uniprot IDP09758
Ensembl Protein ID ENSP00000360269  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation447
SPhosphorylation451
SPhosphorylation455
SPhosphorylation455
TPhosphorylation447
SPhosphorylation451
YPhosphorylation131;-
YPhosphorylation131;-
YPhosphorylation682;-
YPhosphorylation672;-
SPhosphorylation455;-
SPhosphorylation455;-
SPhosphorylation481;-
TPhosphorylation453;-
TPhosphorylation453;-
SPhosphorylation459
SPhosphorylation459
SPhosphorylation478
SPhosphorylation1100
SPhosphorylation1090
SPhosphorylation484
SAcetylation663
SAcetylation653
SPhosphorylation442
SPhosphorylation442
TPhosphorylation445
TPhosphorylation445

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2932GSK3B5418NP_002084.2in vitro10653665   
5566PRKACA3382NP_002721.1in vitro10653665   


Pathway Information


            
Pathway Name Pathway ID
Citrate cycle (TCA cycle) hsa00020
Metabolic pathways hsa01100


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06100856-1093  CCL_ACL-C
cl00416856-1093  CS_ACL-C_CCL superfamily
cd06099890-1085  CS_ACL-C_CCL
cd06101842-1085  citrate_synt
PRK06224842-1097  PRK06224
pfam00549660-785  Ligase_CoA
cl22543660-785  Ligase_CoA superfamily
pfam00285890-1078  Citrate_synt
cd06118890-1085  citrate_synt_like_1
TIGR01800891-1076  cit_synth_II
smart00881492-601  CoA_binding
cl21454492-601  NADB_Rossmann superfamily
cd06114890-1077  EcCS_like
cd06107890-1076  EcCS_AthCS-per_like
pfam02629497-600  CoA_binding
cd06109890-1078  BsCS-I_like
cd06116936-1078  CaCS_like
cd06115932-1036  AthCS_per_like
cd06110888-1078  BSuCS-II_like
cd06108912-1077  Ec2MCS_like
TIGR01798905-1075  cit_synth_I
cd06112890-1076  citrate_synt_like_1_1
PRK14035894-1078  PRK14035
cd06102890-1078  citrate_synt_like_2
cd06113890-996  citrate_synt_like_1_2
PRK14037894-1079  PRK14037
pfam0844255-207  ATP-grasp_2
cl1725555-207  ATP-grasp_4 superfamily
PRK14036959-1076  PRK14036
cd06111919-1076  DsCS_like
PLN02522491-1094  PLN02522
PLN022351-419  PLN02235
COG0074492-805  SucD
COG004530-415  SucC
TIGR01019544-800  sucCoAalpha
PRK05678550-804  PRK05678
COG0372889-1098  GltA
PTZ00187545-805  PTZ00187
PLN00125544-803  PLN00125
TIGR0101655-403  sucCoAbeta
PLN02456891-1073  PLN02456
PRK05614936-1076  gltA
PRK14046185-402  PRK14046
TIGR02717591-793  AcCoA-syn-alpha
PRK00696116-227  sucC


Ontology Information


   
HPRD ID1854
Molecular ClassATPase
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO