Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NEDD4 | 4734 | Neural precursor cell expressed, developmentally down-regulated 4  | 15 | RPF1; NEDD4-1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19024597    | 2008 | Cell line : - Source : - Sample Type : GC,CRC tumor and normal tissue No. of Sample : 103 colorectal and 60 gastric carcinoma tissue Stage : - | Microarray and Immunohistochemistry | Up-regulation | - | Overexpression of NEDD4 indicaes its role in development of CRC and Gastric cancer. |
| 22974840    | 2012 | Cell line : COLO 320, EB, HCT 15, HCT 116, HT 29, IS 1, LoVo, LS 1034, RKO, SW 480 and TC 71 Source : Norwegian Patients Sample Type : - No. of Sample : 114 CRCs and 17 normal colonic mucosa Stage : - | Microarray,Western blotting, Immunocytochemistry and confocal microscopy. | Up-regulation | - | NEDD4 is overexpressed in colorectal cancers, and suggest that NEDD4 promotes growth of colon cancer cells independently of PTEN and PI3K/AKT signaling. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | -   |
| Chromosome | 15 |
| Location | 15q |
| Start | 55826917   |
| End | 55993746   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 166830   |
| OMIM ID | 602278    |
| HGNC ID | HGNC:7727    |
| Unigene ID | Hs.1565     |
| Ensembl ID | ENSG00000069869    |
| PharmGKB ID | PA31533    |
mRNA Information
| mRNA ID | NM_006154.3 |
|---|---|
| Exon | join(1..236,27201..27274,42158..42236,42333..42371, 69048..69101,119739..119789,121271..121332,124066..124168, 130668..130834,132969..133086,133173..133340, 137551..137616,141204..141323,143005..143205, 144861..144941,145172..145226,145317..145375, 146713..146778,151584..151813,153020..153141, 153230..153300,155143..155238,155567..155640, 155898..155958,159461..159520,159602..159709, 160643..160739,163161..163233,163748..166830)   | mRNA Sequence |    Download   Select all |
| Length | 5760   |
CDS Information
| Location | join(192..236,27201..27274,42158..42236,42333..42371, 69048..69101,119739..119789,121271..121332,124066..124168, 130668..130834,132969..133086,133173..133340, 137551..137616,141204..141323,143005..143205, 144861..144941,145172..145226,145317..145375, 146713..146778,151584..151813,153020..153141, 153230..153300,155143..155238,155567..155640, 155898..1 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS45265.1 |    
Protein Information
| Protein ID | NP_001271267.1 |
|---|---|
| Protein Name | Neural precursor cell expressed, developmentally down-regulated 4 |
| Molecular Wt. (Da) | 148984 |
| Protein Sequence |    Download   Select all |
| Length | 1319   |
| Uniprot ID | P33552 |    
| Ensembl Protein ID | ENSP00000364976   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 526 |
| D | Proteolytic Cleavage | 179 |
| D | Proteolytic Cleavage | 526 |
| D | Proteolytic Cleavage | 179 |
| D | Proteolytic Cleavage | 526 |
| D | Proteolytic Cleavage | 179 |
| D | Proteolytic Cleavage | 526 |
| D | Proteolytic Cleavage | 179 |
| S | Phosphorylation | 666 |
| S | Phosphorylation | 319 |
| S | Phosphorylation | 667 |
| S | Phosphorylation | 320 |
| S | Phosphorylation | 670 |
| S | Phosphorylation | 323 |
| S | Phosphorylation | 675 |
| S | Phosphorylation | 328 |
| Y | Phosphorylation | 679 |
| Y | Phosphorylation | 332 |
| T | Phosphorylation | 57 |
| S | Phosphorylation | 58 |
Enzyme Information
| EC | 6.3.2.19 |    
|---|---|
| Name | ubiquitin---protein ligase ubiquitin-activating enzyme |
| Class | Ligases; Forming carbon-nitrogen bonds; Acid-D-amino-acid ligases (peptide synthases) |
| Sysname | ubiquitin:protein-lysine N-ligase (AMP-forming)   |
| Substrate | ATP [CPD:C00002]; ubiquitin [CPD:C00496]; protein lysine   |
| Product | AMP [CPD:C00020]; diphosphate [CPD:C00013]; protein N-ubiquityllysine   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 995 |    CDC25C |    1146 |    NP_001781.2 |    in vitro;in vivo |    10037602    |
| 2887 |    GRB10 |    3312 |    NP_005302.3 |    in vitro;in vivo;yeast 2-hybrid |    1   269   783   410   446   180    |
| 3480 |    IGF1R |    932 |    NP_000866.1 |    in vivo |    12697834    |
| 4778 |    NFE2 |    9030 |    NP_006154.1 |    in vitro |    9305852    |
| 6142 |    RPL18A |    16045 |    NP_000971.1 |    yeast 2-hybrid |    16169070    |
| 6337 |    SCNN1A |    2575 |    NP_001029.1 |    in vitro;in vivo |    106   425   081   021   222   000   000   000    |
| 6338 |    SCNN1B |    2861 |    NP_000327.2 |    in vitro;in vivo |    106   425   081   021   222   000   000   000    |
| 6340 |    SCNN1G |    2862 |    NP_001030.2 |    in vitro;in vivo |    1   064   250   810   212   220   000   000   000   000   000    |
| 30011 |    SH3KBP1 |    2301 |    NP_114098.1 |    in vivo;yeast 2-hybrid |    12218189    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Endocytosis |    hsa04144 |    
| Epstein-Barr virus infection |    hsa05169 |    
| Ubiquitin mediated proteolysis |    hsa04120 |    
Structure Information
| PDB ID | 2CV5 |
|---|---|
| Resolution | 2.5 |
| Method | X-RAY DIFFRACTION |
| Chains | I,J,A   |
| Molecule | ,Histone H3.1   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00078 | 962-1316  | HECTc |
| cl00077 | 962-1316  | HECTc superfamily |
| cd00201 | 895-925  | WW |
| cl00157 | 895-925  | WW superfamily |
| cd00201 | 843-873  | WW |
| cl00157 | 843-873  | WW superfamily |
| cd00201 | 613-643  | WW |
| cl00157 | 613-643  | WW superfamily |
| cd00201 | 770-799  | WW |
| cl00157 | 770-799  | WW superfamily |
| pfam00632 | 1014-1316  | HECT |
| cd04033 | 517-570  | C2_NEDD4_NEDD4L |
| cl14603 | 517-570  | C2 superfamily |
| smart00456 | 893-925  | WW |
| smart00456 | 611-643  | WW |
| smart00456 | 768-799  | WW |
| smart00456 | 842-873  | WW |
| pfam00397 | 612-641  | WW |
| pfam00397 | 894-923  | WW |
| pfam00397 | 769-798  | WW |
| pfam00397 | 842-871  | WW |
| smart00119 | 986-1315  | HECTc |
| COG5021 | 737-1316  | HUL4 |
| COG5104 | 846-923  | PRP40 |
Ontology Information
| HPRD ID | 2362 |    
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Voltage-gated ion channel activity (GO:0005244) |
| Biological Process | Transport (GO:0006810)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

