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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NEDD4 4734 Neural precursor cell expressed, developmentally down-regulated 4  15RPF1; NEDD4-1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19024597   2008Cell line : -

Source : -

Sample Type : GC,CRC tumor and normal tissue

No. of Sample : 103 colorectal and 60 gastric carcinoma tissue

Stage : -

Microarray and ImmunohistochemistryUp-regulation-Overexpression of NEDD4 indicaes its role in development of CRC and Gastric cancer.

22974840   2012Cell line : COLO 320, EB, HCT 15, HCT 116, HT 29, IS 1, LoVo, LS 1034, RKO, SW 480 and TC 71

Source : Norwegian Patients

Sample Type : -

No. of Sample : 114 CRCs and 17 normal colonic mucosa

Stage : -

Microarray,Western blotting, Immunocytochemistry and confocal microscopy.Up-regulation-NEDD4 is overexpressed in colorectal cancers, and suggest that NEDD4 promotes growth of colon cancer cells independently of PTEN and PI3K/AKT signaling.


Gene Details



Chromosome: 15; NC_000015.9 (56119120..56285835, complement)

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Gene Type protein coding
Gene Family -
Description -  
Chromosome 15
Location 15q
Start 55826917  
End 55993746  
Strand -  
Gene Sequence

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Length 166830  
OMIM ID 602278   
HGNC ID HGNC:7727   
Unigene ID Hs.1565    
Ensembl ID ENSG00000069869   
PharmGKB ID PA31533   

mRNA Information


mRNA ID NM_006154.3
Exon join(1..236,27201..27274,42158..42236,42333..42371, 69048..69101,119739..119789,121271..121332,124066..124168, 130668..130834,132969..133086,133173..133340, 137551..137616,141204..141323,143005..143205, 144861..144941,145172..145226,145317..145375, 146713..146778,151584..151813,153020..153141, 153230..153300,155143..155238,155567..155640, 155898..155958,159461..159520,159602..159709, 160643..160739,163161..163233,163748..166830)  
mRNA Sequence

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Length 5760  



CDS Information


   
Location join(192..236,27201..27274,42158..42236,42333..42371, 69048..69101,119739..119789,121271..121332,124066..124168, 130668..130834,132969..133086,133173..133340, 137551..137616,141204..141323,143005..143205, 144861..144941,145172..145226,145317..145375, 146713..146778,151584..151813,153020..153141, 153230..153300,155143..155238,155567..155640, 155898..1
CDS Sequence

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CCDS ID CCDS45265.1



Protein Information


      
Protein IDNP_001271267.1
Protein NameNeural precursor cell expressed, developmentally down-regulated 4
Molecular Wt. (Da)148984
Protein Sequence

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Length 1319  
Uniprot IDP33552
Ensembl Protein ID ENSP00000364976  



Post-translational Modification Information (Source : HPRD)


Residue Type site
DProteolytic Cleavage526
DProteolytic Cleavage179
DProteolytic Cleavage526
DProteolytic Cleavage179
DProteolytic Cleavage526
DProteolytic Cleavage179
DProteolytic Cleavage526
DProteolytic Cleavage179
SPhosphorylation666
SPhosphorylation319
SPhosphorylation667
SPhosphorylation320
SPhosphorylation670
SPhosphorylation323
SPhosphorylation675
SPhosphorylation328
YPhosphorylation679
YPhosphorylation332
TPhosphorylation57
SPhosphorylation58

Enzyme Information


   
EC6.3.2.19
Nameubiquitin---protein ligase
ubiquitin-activating enzyme
ClassLigases; Forming carbon-nitrogen bonds; Acid-D-amino-acid ligases (peptide synthases)
Sysnameubiquitin:protein-lysine N-ligase (AMP-forming)  
SubstrateATP [CPD:C00002]; ubiquitin [CPD:C00496]; protein lysine  
ProductAMP [CPD:C00020]; diphosphate [CPD:C00013]; protein N-ubiquityllysine  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
995CDC25C1146NP_001781.2in vitro;in vivo10037602   
2887GRB103312NP_005302.3in vitro;in vivo;yeast 2-hybrid1   269   783   410   446   180   
3480IGF1R932NP_000866.1in vivo12697834   
4778NFE29030NP_006154.1in vitro9305852   
6142RPL18A16045NP_000971.1yeast 2-hybrid16169070   
6337SCNN1A2575NP_001029.1in vitro;in vivo106   425   081   021   222   000   000   000   
6338SCNN1B2861NP_000327.2in vitro;in vivo106   425   081   021   222   000   000   000   
6340SCNN1G2862NP_001030.2in vitro;in vivo1   064   250   810   212   220   000   000   000   000   000   
30011SH3KBP12301NP_114098.1in vivo;yeast 2-hybrid12218189   


Pathway Information


                  
Pathway Name Pathway ID
Endocytosis hsa04144
Epstein-Barr virus infection hsa05169
Ubiquitin mediated proteolysis hsa04120


Structure Information


PDB ID2CV5
Resolution2.5
MethodX-RAY DIFFRACTION
Chains I,J,A  
Molecule ,Histone H3.1  
Model View



Domain Information




ID Location Description
cd00078962-1316  HECTc
cl00077962-1316  HECTc superfamily
cd00201895-925  WW
cl00157895-925  WW superfamily
cd00201843-873  WW
cl00157843-873  WW superfamily
cd00201613-643  WW
cl00157613-643  WW superfamily
cd00201770-799  WW
cl00157770-799  WW superfamily
pfam006321014-1316  HECT
cd04033517-570  C2_NEDD4_NEDD4L
cl14603517-570  C2 superfamily
smart00456893-925  WW
smart00456611-643  WW
smart00456768-799  WW
smart00456842-873  WW
pfam00397612-641  WW
pfam00397894-923  WW
pfam00397769-798  WW
pfam00397842-871  WW
smart00119986-1315  HECTc
COG5021737-1316  HUL4
COG5104846-923  PRP40


Ontology Information


   
HPRD ID2362
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionVoltage-gated ion channel activity (GO:0005244)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO