Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ATOH1 | 474 | Atonal homolog 1 (Drosophila) | 4 | ATH1; HATH1; MATH-1; bHLHa14 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15342386 | 2004 | Cell line : - Source : ATCC Sample Type : - No. of Sample : - Stage : - | Immunofluorescent Staining, Immunohistochemistry and Histochemistry, RT-PCR, Luciferase Assay | Down-regulation | - | Down-regulation of Hathl can result in reduced expression of goblet cell differentiation marker, MUC2, which contributes toward the progression of neoplastic growth. Hath1 may be a novel factor downstream of the Wnt pathway capable of suppressing anchorage-independent growth of colon cancer cell lines. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008] |
| Chromosome | 4 |
| Location | 4q22 |
| Start | 93828927 |
| End | 93829991 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 1065 |
| OMIM ID | 601461 |
| HGNC ID | HGNC:797 |
| Unigene ID | Hs.532680 |
| Ensembl ID | ENSG00000172238 |
| PharmGKB ID | - |
Protein Information
| Protein ID | NP_005163.1 |
|---|---|
| Protein Name | Atonal homolog 1 (Drosophila) |
| Molecular Wt. (Da) | 38029 |
| Protein Sequence | Download Select all |
| Length | 354 |
| Uniprot ID | P02765 |
| Ensembl Protein ID | ENSP00000393887 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3146 | HMGB1 | 1228 | NP_002119.1 | in vitro | 11748221 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1C8Q |
|---|---|
| Resolution | 2.3 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | ALPHA-AMYLASE |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 158-216 | HLH |
| cl00081 | 158-216 | HLH superfamily |
| smart00353 | 165-217 | HLH |
| pfam00010 | 160-211 | HLH |
Ontology Information
| HPRD ID | 727 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Defense/immunity protein activity (GO:0003793) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.