Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19151752 | 2009 | Cell line : HT-29 , DLD 1, MKN 45 . Source : ATCC, ,Health Science Bank, Osaka, Japan,Health Science Bank. Sample Type : - No. of Sample : - Stage : - | Cell growth, cell migration and invasion,Cell adhesion,Immunoprecipitation, immunoblotting and lectin blotting,Indirect immunofluorescence microscopy | Down-regulation | - | NEU1 is important in regulation of integrin beta4-mediated signaling, leading to suppression of metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008] |
| Chromosome | 6 |
| Location | 6p21 |
| Start | 31826829 |
| End | 31830709 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3881 |
| OMIM ID | 608272 |
| HGNC ID | HGNC:7758 |
| Unigene ID | Hs.520037 |
| Ensembl ID | ENSG00000204386 |
| PharmGKB ID | PA31560 |
mRNA Information
| mRNA ID | NM_000434.3 |
|---|---|
| Exon | join(1..315,742..934,1483..1745,2312..2494,2669..2891, 2988..3881) | mRNA Sequence | Download Select all |
| Length | 2088 |
Protein Information
| Protein ID | NP_000425.1 |
|---|---|
| Protein Name | sialidase 1 (lysosomal sialidase) |
| Molecular Wt. (Da) | 320795 |
| Protein Sequence | Download Select all |
| Length | 415 |
| Uniprot ID | P22415 |
| Ensembl Protein ID | ENSP00000356999 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 242 |
| S | Phosphorylation | 244 |
| Y | Phosphorylation | 251 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2720 | GLB1 | 1975 | NP_000395.2 | in vitro;in vivo | 39 227 583 102 233 |
| 5476 | CTSA | 2020 | NP_000299.2 | in vitro;in vivo | 950 108 039 227 583 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Lysosome | hsa04142 |
| Other glycan degradation | hsa00511 |
| Sphingolipid metabolism | hsa00600 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd15482 | 62-410 | Sialidase_non-viral |
| cl21531 | 62-410 | Sialidase superfamily |
| pfam13088 | 88-380 | BNR_2 |
| pfam13859 | 88-248 | BNR_3 |
| COG4409 | 14-127 | NanH |
Ontology Information
| HPRD ID | 3415 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | Cytoskeletal protein binding (GO:0008092) |
| Biological Process | Cytoskeleton organization and biogenesis (GO:0007010) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q99519 | DB00198 | Oseltamivir | SmallMoleculeDrug |