Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NFE2L2 | 4780 | Nuclear factor (erythroid-derived 2)-like 2 | 2 | NRF2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19719968 | 2009 | Cell line : Caco 2 Source : Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (Shanghai, China). Sample Type : - No. of Sample : - Stage : - | RT-PCR, Western blotting | Down-regulation | - | EGCG up-regulated the expression of Nrf2 and increased the level of UGT1A in cells. The human colon cancer cell line Caco-2 purchased from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (Shanghai, China). |
| 22269287 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | - |
| 22526619 | 2012 | Cell line : HCT 116 Source : - Sample Type : - No. of Sample : - Stage : - | Diamidino-phenyl-indole (DAPI) and annexin V/PI staining, | Down-regulation | - | Oroxylin A is a flavonoid found commonly used as an antipyretic, analgesic, antitumor, and anti-inflammatory agent, increased nuclear transcription factor erythroid-related factor 2 (Nrf2) and its target genes heme oxygenase-1 and NADP(H):quinone oxidoreductase-1 in HCT-116 cells. |
| 22559738 | 2012 | Cell line : Caco 2 Source : Institute of Cytobiology, Chinese Academy of Sciences, Shanghai, PRC. Sample Type : - No. of Sample : - Stage : - | Cell Viability Assay, Western Blotting, real time RT-PCR, HPLC, Nrf2 Nuclear Translocation Analysis | Down-regulation | - | SFN- induced UGT1A expression may have resulted from Nrf2 nuclear translocation or activation. Human colon cancer Caco-2 cells were included in this study. |
| 19138955 | 2008 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry, Western blotting | Unknown | - | Nrf2 plays a critical role in protecting against inflammation-associated colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | basic leucine zipper proteins |
| Description | This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| Chromosome | 2 |
| Location | 2q31 |
| Start | 177230303 |
| End | 177265131 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 34829 |
| OMIM ID | 600492 |
| HGNC ID | HGNC:7782 |
| Unigene ID | Hs.744006 |
| Ensembl ID | ENSG00000116044 |
| PharmGKB ID | PA31588 |
mRNA Information
| mRNA ID | NM_006164.4 |
|---|---|
| Exon | join(1..600,30861..31127,31793..31882,32549..32740, 33124..34829) | mRNA Sequence | Download Select all |
| Length | 2859 |
CDS Information
| Location | join(556..600,30861..31127,31793..31882,32549..32740, 33124..34347) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS42782.1 |
Protein Information
| Protein ID | NP_001138884.1 |
|---|---|
| Protein Name | Nuclear factor (erythroid-derived 2)-like 2 |
| Molecular Wt. (Da) | 65946 |
| Protein Sequence | Download Select all |
| Length | 589 |
| Uniprot ID | A8K7I4 |
| Ensembl Protein ID | ENSP00000234701 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 40 |
| S | Phosphorylation | 215 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 834 | CASP1 | 977 | NP_150634.1 | in vivo;yeast 2-hybrid | 10510468 |
| 1387 | CREBBP | 2534 | NP_004371.2 | in vitro;in vivo;yeast 2-hybrid | 11683914 |
| 3727 | JUND | 1304 | NP_005345.3 | in vivo | 9872330 |
| 7975 | MAFK | 2561 | NP_002351.1 | in vitro;in vivo | 11 013 233 107 479 000 000 000 |
| 84181 | CHD6 | 13049 | NP_115597.3 | in vivo;yeast 2-hybrid | 16314513 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Protein processing in endoplasmic reticulum | hsa04141 |
Structure Information
| PDB ID | 2FLU |
|---|---|
| Resolution | 1.5 |
| Method | X-RAY DIFFRACTION |
| Chains | X |
| Molecule | Kelch-like ECH-associated protein 1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14720 | 494-561 | bZIP_NFE2-like |
| cl21462 | 494-561 | bZIP superfamily |
| cd14698 | 494-561 | bZIP_CNC |
| cd14719 | 494-561 | bZIP_BACH |
| pfam03131 | 468-561 | bZIP_Maf |
| smart00338 | 498-558 | BRLZ |
| cd14691 | 499-542 | bZIP_XBP1 |
| cd14696 | 502-558 | bZIP_Jun |
| cd14686 | 501-542 | bZIP |
| cd14699 | 499-557 | bZIP_Fos_like |
| pfam00170 | 502-564 | bZIP_1 |
| cd14697 | 502-561 | bZIP_Maf |
| cd14721 | 502-557 | bZIP_Fos |
| cd14687 | 502-558 | bZIP_ATF2 |
| cd14690 | 499-542 | bZIP_CREB1 |
| cd14809 | 502-539 | bZIP_AUREO-like |
| pfam07716 | 502-542 | bZIP_2 |
| cd14722 | 499-554 | bZIP_ATF3 |
| cd14704 | 502-542 | bZIP_HY5-like |
| cd12193 | 502-542 | bZIP_GCN4 |
| cd14717 | 502-560 | bZIP_Maf_small |
| cd14693 | 501-560 | bZIP_CEBP |
| cd14718 | 502-543 | bZIP_Maf_large |
| cd14688 | 502-560 | bZIP_YAP |
| cd14707 | 502-546 | bZIP_plant_BZIP46 |
| cd14692 | 502-555 | bZIP_ATF4 |
Ontology Information
| HPRD ID | 4188 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Intracellular ligand-gated ion channel activity (GO:0005217) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.