Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NFIL3 | 4783 | nuclear factor, interleukin 3 regulated | 9 | E4BP4, NFIL3A, NF-IL3A |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26156959 | 2015 | Cell line : - Source : - Sample Type : Mouse model No. of Sample : - Stage : - | Microarray analysis | Up-regulation | - | New direct Wnt/?-catenin target genes, BOP1, CKS2 and NFIL3, which induced EMT, cell migration and experimental metastasis of CRC cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | basic leucine zipper proteins |
| Description | The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014] |
| Chromosome | 9 |
| Location | 9q22 |
| Start | 94171327 |
| End | 94186908 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 15582 |
| OMIM ID | 605327 |
| HGNC ID | HGNC:7787 |
| Unigene ID | Hs.79334 |
| Ensembl ID | ENSG00000165030 |
| PharmGKB ID | PA31593 |
mRNA Information
| mRNA ID | NM_001290000.1 |
|---|---|
| Exon | join(1..218,13721..15582) | mRNA Sequence | Download Select all |
| Length | 2099 |
Protein Information
| Protein ID | NP_001276929.1 |
|---|---|
| Protein Name | nuclear factor, interleukin 3 regulated |
| Molecular Wt. (Da) | 24024 |
| Protein Sequence | Download Select all |
| Length | 462 |
| Uniprot ID | P19320 |
| Ensembl Protein ID | ENSP00000294728 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 301;- |
| S | Phosphorylation | 285 |
| S | Phosphorylation | 286 |
| S | Phosphorylation | 353 |
| S | Phosphorylation | 275 |
| S | Phosphorylation | 352 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1810 | DR1 | 3284 | NP_001929.1 | in vitro;in vivo | 8836190 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14694 | 72-131 | bZIP_NFIL3 |
| cl21462 | 72-131 | bZIP superfamily |
| pfam06529 | 130-462 | Vert_IL3-reg_TF |
| cl05841 | 130-462 | Vert_IL3-reg_TF superfamily |
| cd14695 | 72-123 | bZIP_HLF |
| pfam07716 | 72-123 | bZIP_2 |
| cd14686 | 76-123 | bZIP |
| smart00338 | 71-123 | BRLZ |
| cd14813 | 76-123 | bZIP_BmCbz-like |
| cd12193 | 79-123 | bZIP_GCN4 |
| cd14693 | 76-121 | bZIP_CEBP |
| cd14713 | 76-126 | bZIP_CEBPG |
| cd14690 | 79-123 | bZIP_CREB1 |
| cd14691 | 79-126 | bZIP_XBP1 |
| cd14705 | 78-123 | bZIP_Zip1 |
| pfam00170 | 79-123 | bZIP_1 |
| cd14714 | 76-124 | bZIP_CEBPD |
| cd14692 | 79-123 | bZIP_ATF4 |
Ontology Information
| HPRD ID | 1889 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Growth factor activity (GO:0008083) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.