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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NFKBIA 4792 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha  14IKBA, MAD-3, IkappaBalpha 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17354114   2007Cell line : -

Source : Swedish and Chinese population

Sample Type : Population based case control study

No. of Sample : 354 CRC and 1015 controls

Stage : Duke stage A-D

RFLP-PCRPolymorhpism-AG genotype of�NFKBIA�may be at an increased risk of developing CRC, and the GG genotype of�NFKBIA�may be considered as a prognostic factor for Swedish CRC patients.

24367615   2013Cell line : -

Source : Sheffield Royal Hallamshire and the Sheffield Northern General hospitals.

Sample Type : -

No. of Sample : -

Stage : -

 MSI Analysis,Sequencing and mutation analysisPolymorhpism-Apoptosis and p53 signalling pathways were commonly affected by deleted FMCR,Candidate tumour suppressor genes in deleted FMCR included RASSF3, IFNAR1, IFNAR2 and NFKBIA.


Gene Details



NC_000014.8 (35870716..35873960, complement)

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Gene Type protein coding
Gene Family Ankyrin repeat domain containing
Description This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]  
Chromosome 14
Location 14q13
Start 35870716  
End 35873960  
Strand -  
Gene Sequence

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Length 3245  
OMIM ID 164008   
HGNC ID HGNC:7797   
Unigene ID Hs.81328   
Ensembl ID ENSG00000100906   
PharmGKB ID PA31601   

mRNA Information


mRNA ID NM_020529.2
Exon join(1..337,957..1065,1395..1605,1896..1984,2092..2361, 2695..3245)  
mRNA Sequence

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Length 1579  



CDS Information


   
Location 111..1064
CDS Sequence

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CCDS ID CCDS9656.1



Protein Information


      
Protein IDNP_065390.1
Protein Namenuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Molecular Wt. (Da)33750
Protein Sequence

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Length 317  
Uniprot IDP49765
Ensembl Protein ID ENSP00000311127  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KUbiquitination21
KUbiquitination22
SPhosphorylation283
SPhosphorylation288
TPhosphorylation291
SPhosphorylation293
SPhosphorylation32
SPhosphorylation36
YPhosphorylation42
SPhosphorylation32
YPhosphorylation42
SPhosphorylation32
SPhosphorylation32
SPhosphorylation36
KSumoylation21
SPhosphorylation36
SPhosphorylation36
YDephosphorylation42
SPhosphorylation32
TPhosphorylation90

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
291SLC25A458NP_001142.2in vitro;in vivo;yeast 2-hybrid11287411   
823CAPN1253NP_005177.2in vitro10521480   
1147CHUK2811NP_001269.3in vitro;in vivo9   244   310   925   218   610   000   000   000   000   000   000   000   000   000   000   
3217HOXB7850NP_004493.3in vivo10026139   
3315HSPB19076NP_001531.1in vitro12897149   
4174MCM54075NP_006730.2in vivo14743216   
4215MAP3K33965NP_976226.1in vitro;in vivo10085062   
4791NFKB21239NP_001070962.1in vitro14743216   
4793NFKBIB7260NP_002494.2in vitro14743216   
5584PRKCI2105NP_002731.4in vitro10848576   
5783PTPN132602NP_542416.1in vitro;in vivo;yeast 2-hybrid111   064   289   882   613   
5966REL1286NP_002899.1in vitro14743216   
6500SKP13255NP_733779.1in vitro14743216   
7322UBE2D24268NP_003330.1in vitro;in vivo10329681   
7323UBE2D34269NP_871622.1in vitro;in vivo10329681   
8454CUL14389NP_003583.2in vitro14743216   
8517IKBKG2217NP_001093326.2in vitro1   474   321   616   319   050   
8518IKBKAP4763NP_003631.2in vitro14743216   
9612NCOR22910NP_006303.3in vivo12589049   
9883POM12111448NP_742017.1yeast 2-hybrid16189514   
10746MAP3K210068NP_006600.3in vitro;in vivo10085062   
28511NKIRAS27261NP_060065.2in vitro;in vivo10657303   
28512NKIRAS16841NP_065078.1in vitro;in vivo10657303   
219541MED1917477NP_703151.1yeast 2-hybrid16169070   


Pathway Information


                                                                                                                                                                                                      
Pathway Name Pathway ID
Adipocytokine signaling pathway hsa04920
Apoptosis hsa04210
B cell receptor signaling pathway hsa04662
cAMP signaling pathway hsa04024
Chagas disease (American trypanosomiasis) hsa05142
Chemokine signaling pathway hsa04062
Chronic myeloid leukemia hsa05220
Cytosolic DNA-sensing pathway hsa04623
Epithelial cell signaling in Helicobacter pylori infection hsa05120
Epstein-Barr virus infection hsa05169
Hepatitis B hsa05161
Hepatitis C hsa05160
Herpes simplex infection hsa05168
HTLV-I infection hsa05166
Influenza A hsa05164
Insulin resistance hsa04931
Legionellosis hsa05134
Leishmaniasis hsa05140
Measles hsa05162
Neurotrophin signaling pathway hsa04722
NF-kappa B signaling pathway hsa04064
NOD-like receptor signaling pathway hsa04621
Osteoclast differentiation hsa04380
Pathways in cancer hsa05200
Prostate cancer hsa05215
RIG-I-like receptor signaling pathway hsa04622
Shigellosis hsa05131
Small cell lung cancer hsa05222
T cell receptor signaling pathway hsa04660
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00204105-237  ANK
cl02529105-237  ANK superfamily
cd00204140-256  ANK
cd0020472-203  ANK
cd0020471-163  ANK
pfam00023182-212  Ank
pfam00023216-247  Ank
pfam00023112-141  Ank
smart00248182-211  ANK
pfam13606216-244  Ank_3
smart00248216-244  ANK
pfam13606182-211  Ank_3
smart00248113-139  ANK
pfam12796148-246  Ank_2
pfam1363774-131  Ank_4
pfam12796115-212  Ank_2
PHA03100113-253  PHA03100
COG066673-238  ANKYR
PHA03100102-244  PHA03100
pfam12796187-253  Ank_2
COG066674-238  ANKYR
PHA02741140-256  PHA02741
PHA02878109-253  PHA02878
PHA0309575-253  PHA03095
PHA0287476-253  PHA02874
COG066657-166  ANKYR
PHA03095104-253  PHA03095
PHA02875113-247  PHA02875
PHA02874104-253  PHA02874
PHA02878114-244  PHA02878
pfam13857104-151  Ank_5
TIGR00870105-244  trp
pfam13637183-237  Ank_4
PLN03192128-256  PLN03192
PHA02736140-265  PHA02736
PHA02875118-256  PHA02875
COG0666140-256  ANKYR
PHA0309527-151  PHA03095
PHA0287630-253  PHA02876
pfam13857202-256  Ank_5
PHA02743180-269  PHA02743
PHA02875105-253  PHA02875
PHA02876102-253  PHA02876
PHA03100104-215  PHA03100
PTZ00322127-204  PTZ00322
PHA0287573-250  PHA02875
pfam1279678-141  Ank_2
PTZ00322180-239  PTZ00322
PHA02874125-253  PHA02874
PHA02876196-252  PHA02876
pfam13637113-155  Ank_4
pfam13637144-203  Ank_4
pfam13857178-224  Ank_5
PTZ00322112-171  PTZ00322
PHA0287497-253  PHA02874
PHA02876102-243  PHA02876
TIGR0087040-203  trp
PHA02859184-256  PHA02859
PHA02884168-257  PHA02884
PHA02716183-253  PHA02716
PTZ00322188-256  PTZ00322
PHA02884195-245  PHA02884
PHA02736113-153  PHA02736
pfam13637217-253  Ank_4
PHA02798181-291  PHA02798


Ontology Information


   
HPRD ID1905
Molecular ClassTranscription regulatory protein
Molecular FunctionUbiquitin-specific protease activity (GO:0004843)
Biological ProcessProtein metabolism (GO:0019538); Regulation of gene expression, epigenetic (GO:0040029); Anti-apoptosis (GO:0006916)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P25963DB00945Acetylsalicylic acidSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO