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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NGFR 4804 nerve growth factor receptor  17TNFRSF16, CD271, p75NTR 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25244921   2015Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

 Bisulfite genomic sequencing, real time RT-PCR, immunoblottingMethylation-p75NGFR is a candidate tumor suppressor and has independent prognostic potential in colorectal cancer.


Gene Details



NC_000017.10 (47572655..47592382)

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Gene Type protein coding
Gene Family Tumor necrosis factor receptor superfamily, "CD molecules"
Description Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]  
Chromosome 17
Location 17q21-q22
Start 47572655  
End 47592382  
Strand +  
Gene Sequence

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Length 19728  
OMIM ID 162010   
HGNC ID HGNC:7809   
Unigene ID Hs.415768   
Ensembl ID ENSG00000064300   
PharmGKB ID PA31615   

mRNA Information


mRNA ID NM_002507.3
Exon join(1..191,6771..6912,11007..11366,15120..15372, 16600..16760,17416..19728)  
mRNA Sequence

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Length 3420  



CDS Information


   
Location 126..1409
CDS Sequence

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CCDS ID CCDS11549.1



Protein Information


      
Protein IDNP_002498.1
Protein Namenerve growth factor receptor
Molecular Wt. (Da)30006
Protein Sequence

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Length 427  
Uniprot IDP15311
Ensembl Protein ID ENSP00000338934  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation303
SPhosphorylation313

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2885GRB2150NP_002077.1in vitro;in vivo9368064   
3558IL2979NP_000577.2in vitro1316918   
4099MAG1160NP_002352.1in vivo12011108   
4793NFKBIB7260NP_002494.2in vitro;in vivo12034707   
5594MAPK11496NP_002736.3in vitro;in vivo8407983   
5595MAPK33479NP_002737.2in vitro;in vivo8407983   
6272SORT13910NP_002950.3in vivo14985763   
8717TRADD4610NP_003780.1in vivo12604596   
10782ZNF2745682NP_057409.1in vitro;in vivo10545116   


Pathway Information


                                    
Pathway Name Pathway ID
Cytokine-cytokine receptor interaction hsa04060
Neurotrophin signaling pathway hsa04722
PI3K-Akt signaling pathway hsa04151
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Transcriptional misregulation in cancer hsa05202


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1341630-188  TNFRSF16
cl2285530-188  TNFRSF superfamily
cd08311340-418  Death_p75NR
cl14633340-418  DD superfamily
cd1583432-172  TNFRSF1A_teleost
cd1340737-188  TNFRSF5
cd1583732-146  TNFRSF26
smart00005340-420  DEATH
cd0018543-129  TNFRSF
cd1057743-171  TNFRSF1B
cd1057544-174  TNFRSF6B
cd00185125-189  TNFRSF
cd1340632-189  TNFRSF4
cd1058144-156  TNFRSF11B
cd1057932-148  TNFRSF6
cd1342233-189  TNFRSF5_teleost
cd1341133-188  TNFRSF11A
cd1342443-160  TNFRSF9_teleost
cd1057632-147  TNFRSF1A
cd13405109-189  TNFRSF14_teleost
cd13406120-193  TNFRSF4
cd10581116-196  TNFRSF11B
cd15835104-195  TNFRSF1B_teleost
cd1058344-170  TNFRSF21
pfam00531345-421  Death
cd1342331-128  TNFRSF6_teleost
cd15834109-189  TNFRSF1A_teleost
cd10576109-188  TNFRSF1A
cd1340532-131  TNFRSF14_teleost
pfam00020149-188  TNFR_c6
cd10575116-193  TNFRSF6B
cd13423109-188  TNFRSF6_teleost
cd15837125-189  TNFRSF26
cd1341244-152  TNFRSF11B_teleost
pfam00020109-146  TNFR_c6
cd1583937-150  TNFRSF_viral
cd1058043-147  TNFRSF10
cd10582115-211  TNFRSF14
cd10580125-188  TNFRSF10
cd15839109-193  TNFRSF_viral
cd13412114-189  TNFRSF11B_teleost
cd1583528-133  TNFRSF1B_teleost
cd1058237-126  TNFRSF14
smart00208113-146  TNFR
smart00208149-188  TNFR
cd1583430-131  TNFRSF1A_teleost
cd1341056-188  TNFRSF9
cd10578107-193  TNFRSF3
cd15836115-195  TNFRSF11A_teleost
cd13410125-193  TNFRSF9
cd10583113-200  TNFRSF21
cd1057632-114  TNFRSF1A
cd1342232-107  TNFRSF5_teleost
cd13419122-188  TNFRSF19L
cd10579125-188  TNFRSF6


Ontology Information


   
HPRD ID2890
Molecular ClassCell surface receptor
Molecular FunctionCalcium ion binding (GO:0005509)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO