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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Down-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. |
| 17328794 | 2007 | Cell line : SW48, RKO Source : - Sample Type : - No. of Sample : 49 CRC patients 24 Healthy control Stage : - | Methylation specific PCR, RT-PCR, and Immunohistochemistry | Methylation | - | Loss of nidogens expression has a potential pathogenetic role in colon and stomach tumorigenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1q43 |
| Start | 235975830 |
| End | 236065181 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 89352 |
| OMIM ID | 131390 |
| HGNC ID | HGNC:7821 |
| Unigene ID | Hs.356624 |
| Ensembl ID | ENSG00000116962 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002508.2 |
|---|---|
| Exon | join(1..327,16193..16492,19499..19725,22890..23272, 26929..27078,32530..32781,35432..35632,39041..39286, 40969..41112,47909..48034,51622..51771,53139..53261, 71310..71537,74124..74296,79677..79803,83400..83571, 84529..84686,85237..85360,86075..86187,87194..89352) | mRNA Sequence | Download Select all |
| Length | 5903 |
CDS Information
| Location | join(103..327,16193..16492,19499..19725,22890..23272, 26929..27078,32530..32781,35432..35632,39041..39286, 40969..41112,51622..51771,53139..53261,71310..71537, 74124..74296,79677..79803,83400..83571,84529..84686, 85237..85360,86075..86187,87194..87315) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_002499.2 |
|---|---|
| Protein Name | Nidogen 1 |
| Molecular Wt. (Da) | 133458 |
| Protein Sequence | Download Select all |
| Length | 1247 |
| Uniprot ID | P51793 |
| Ensembl Protein ID | ENSP00000370213 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 351 | APP | 100 | NP_000475.1 | in vitro | 11376898 |
| 1277 | COL1A1 | 362 | NP_000079.2 | in vitro | 9733643 |
| 1282 | COL4A1 | 359 | NP_001836.2 | in vitro | 2506015 |
| 1305 | COL13A1 | 383 | NP_005194.3 | in vitro | 11956183 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00255 | 429-660 | nidG2 |
| cl00186 | 429-660 | nidG2 superfamily |
| cd00191 | 849-919 | TY |
| cl00150 | 849-919 | TY superfamily |
| cd00054 | 802-840 | EGF_CA |
| cl21504 | 802-840 | EGF_CA superfamily |
| cd00054 | 710-743 | EGF_CA |
| cl21504 | 710-743 | EGF_CA superfamily |
| smart00682 | 427-666 | G2F |
| pfam07474 | 428-626 | G2F |
| smart00539 | 106-269 | NIDO |
| cl02648 | 106-269 | NIDO superfamily |
| pfam06119 | 176-268 | NIDO |
| pfam00086 | 849-919 | Thyroglobulin_1 |
| smart00211 | 875-921 | TY |
| smart00135 | 1014-1055 | LY |
| cl22866 | 1014-1055 | LY superfamily |
| smart00135 | 1056-1100 | LY |
| cl22866 | 1056-1100 | LY superfamily |
| pfam12947 | 811-839 | EGF_3 |
| smart00179 | 802-840 | EGF_CA |
| cd05819 | 1019-1176 | NHL |
| cl18310 | 1019-1176 | NHL superfamily |
| pfam14670 | 1212-1242 | FXa_inhibition |
| cl21504 | 1212-1242 | EGF_CA superfamily |
| pfam00058 | 1033-1072 | Ldl_recept_b |
| cl22870 | 1033-1072 | Ldl_recept_b superfamily |
| pfam00058 | 992-1029 | Ldl_recept_b |
| cl22870 | 992-1029 | Ldl_recept_b superfamily |
| cd05819 | 1020-1177 | NHL |
| cd14963 | 1019-1117 | NHL_like_5 |
| pfam00058 | 1076-1117 | Ldl_recept_b |
| cl22870 | 1076-1117 | Ldl_recept_b superfamily |
| pfam12947 | 762-800 | EGF_3 |
| cl21504 | 762-800 | EGF_CA superfamily |
| smart00179 | 710-751 | EGF_CA |
| pfam12947 | 390-425 | EGF_3 |
| cl21504 | 390-425 | EGF_CA superfamily |
| pfam07645 | 710-749 | EGF_CA |
| cd00053 | 805-840 | EGF |
| cd14952 | 937-1086 | NHL_PKND_like |
| smart00135 | 982-1011 | LY |
| cl22866 | 982-1011 | LY superfamily |
| pfam12947 | 672-708 | EGF_3 |
| cl21504 | 672-708 | EGF_CA superfamily |
| cd14952 | 1012-1177 | NHL_PKND_like |
| smart00135 | 1101-1137 | LY |
| cl22866 | 1101-1137 | LY superfamily |
| pfam07645 | 802-839 | EGF_CA |
| cd14952 | 1019-1176 | NHL_PKND_like |
| pfam12662 | 784-805 | cEGF |
| smart00181 | 805-840 | EGF |
| pfam12662 | 693-713 | cEGF |
| cd14955 | 1022-1084 | NHL_like_4 |
| cl18310 | 1022-1084 | NHL superfamily |
| cd14955 | 1022-1084 | NHL_like_4 |
| cd14956 | 1022-1084 | NHL_like_3 |
| cd00053 | 713-743 | EGF |
| smart00179 | 759-801 | EGF_CA |
| pfam06247 | 693-836 | Plasmod_Pvs28 |
| COG3391 | 976-1218 | YncE |
| pfam08450 | 992-1132 | SGL |
Ontology Information
| HPRD ID | 2139 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Intracellular ligand-gated ion channel activity (GO:0005217) |
| Biological Process | Transport (GO:0006810) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P14543 | DB00013 | Urokinase | BiotechDrug |