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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | 17 | NM23, NM23-H1, NDPKA |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25957329 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 149 Stage : - | Direct Sanger DNA sequencing | Polymorhpism | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q21.33 |
| Start | 49230920 |
| End | 49239450 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8531 |
| OMIM ID | 156490 |
| HGNC ID | HGNC:7849 |
| Unigene ID | Hs.463456 |
| Ensembl ID | ENSG00000239672 |
| PharmGKB ID | PA249 |
mRNA Information
| mRNA ID | NM_001018136.2 |
|---|---|
| Exon | join(<1..104,2093..2222,6422..6523,7602..7714) | mRNA Sequence | Download Select all |
| Length | 1092 |
Protein Information
| Protein ID | NP_001018146.1 |
|---|---|
| Protein Name | NME/NM23 nucleoside diphosphate kinase 1 |
| Molecular Wt. (Da) | 54101 |
| Protein Sequence | Download Select all |
| Length | 267 |
| Uniprot ID | P08670 |
| Ensembl Protein ID | ENSP00000224237 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 120 |
| S | Phosphorylation | 122 |
| S | Phosphorylation | 125 |
| S | Phosphorylation | 44 |
| S | Phosphorylation | 145 |
| S | Phosphorylation | 147 |
| S | Phosphorylation | 150 |
| S | Phosphorylation | 69 |
| T | Phosphorylation | 94 |
| T | Phosphorylation | 119 |
| K | Acetylation | 100 |
| K | Acetylation | 125 |
| K | Acetylation | 12 |
| K | Acetylation | 37 |
| K | Acetylation | 56 |
| K | Acetylation | 81 |
| S | Phosphorylation | 99 |
| S | Phosphorylation | 124 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 328 | APEX1 | 136 | NP_542380.1 | in vitro | 12524539 |
| 3688 | ITGB1 | 628 | NP_391987.1 | in vitro;in vivo | 11919189 |
| 4833 | NME4 | 3489 | NP_005000.1 | yeast 2-hybrid | 16189514 |
| 7013 | TERF1 | 2975 | NP_059523.2 | in vitro;yeast 2-hybrid | 9480811 |
| 8844 | KSR1 | 18980 | NP_055053.1 | in vitro;in vivo | 12105213 |
| 9533 | POLR1C | 9661 | NP_976035.1 | yeast 2-hybrid | 16189514 |
| 26003 | GORASP2 | 8303 | NP_056345.3 | yeast 2-hybrid | 16189514 |
| 55093 | WDYHV1 | 7653 | NP_060494.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolic pathways | hsa01100 |
| Purine metabolism | hsa00230 |
| Pyrimidine metabolism | hsa00240 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04413 | 5-134 | NDPk_I |
| cl00335 | 5-134 | NDPk superfamily |
| PTZ00093 | 5-151 | PTZ00093 |
| PRK00668 | 5-137 | ndk |
| COG0105 | 5-134 | Ndk |
| cd00595 | 5-134 | NDPk |
| PRK14540 | 5-134 | PRK14540 |
| PRK14541 | 5-140 | PRK14541 |
| PRK14545 | 6-138 | PRK14545 |
| PRK14542 | 5-139 | PRK14542 |
| PRK14543 | 5-142 | PRK14543 |
| cd04415 | 5-134 | NDPk7A |
| PLN02931 | 5-134 | PLN02931 |
| cd04418 | 5-134 | NDPk5 |
| cd04414 | 5-134 | NDPk6 |
| cd04416 | 5-134 | NDPk_TX |
| cd04412 | 3-134 | NDPk7B |
| pfam00334 | 5-139 | NDK |
| PLN02619 | 2-152 | PLN02619 |
| smart00562 | 5-139 | NDK |
| PRK14544 | 5-141 | PRK14544 |
Ontology Information
| HPRD ID | 1902 |
|---|---|
| Molecular Class | Enzyme: Phosphotransferase |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P15531 | DB00300 | Tenofovir | SmallMoleculeDrug |
| P15531 | DB00709 | Lamivudine | SmallMoleculeDrug |
| P15531 | DB00718 | Adefovir Dipivoxil | SmallMoleculeDrug |