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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NONO 4841 non-POU domain containing, octamer-binding  XNRB54, NMT55, P54NRB, P54, PPP1R114 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22118625   2011Cell line : SW480, HT29

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Mass spectrometry,RT-PCRUp-regulation-NONO or RALY significant counteracts oxaliplatin resistance in colorectal cancers overexpressing the YB-1 protein.


Gene Details



NC_000023.10 (70503042..70521018)

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Gene Type protein coding
Gene Family RNA binding motif (RRM) containing
Description This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]  
Chromosome X
Location Xq13.1
Start 70503042  
End 70521018  
Strand +  
Gene Sequence

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Length 17977  
OMIM ID 300084   
HGNC ID HGNC:7871   
Unigene ID Hs.533282   
Ensembl ID ENSG00000147140   
PharmGKB ID PA31680   

mRNA Information


mRNA ID NM_001145408.1
Exon join(1..530,1206..1262,1793..1906,7438..7600,8588..8781, 11036..11337,13374..13469,13660..13856,14186..14270, 14645..14747,15278..15317,15516..15625,16751..17977)  
mRNA Sequence

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Length 3228  



CDS Information


   
Location711..2126
CDS Sequence

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CCDS ID CCDS14410.1



Protein Information


      
Protein IDNP_001138880.1
Protein Namenon-POU domain containing, octamer-binding
Molecular Wt. (Da)160840
Protein Sequence

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Length 471  
Uniprot IDP62760
Ensembl Protein ID ENSP00000295156  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation450;-
TPhosphorylation432;-
SPhosphorylation147
TPhosphorylation428
KAcetylation198
YAcetylation0
KAcetylation5
KAcetylation11
KAcetylation96
KAcetylation467
KAcetylation107
KAcetylation64
SPhosphorylation209
TPhosphorylation440
SPhosphorylation149
TPhosphorylation15
SPhosphorylation188
TPhosphorylation424

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
760CA22023NP_000058.1in vitro10821857   
5300PIN13031NP_006212.1yeast 2-hybrid16189514   
6688SPI11305NP_001074016.1in vitro;in vivo8626664   
8379MAD1L14065NP_003541.2yeast 2-hybrid16189514   
9513FXR25629NP_004851.2yeast 2-hybrid16189514   
30834ZNRD19601NP_740753.1yeast 2-hybrid16189514   
55269PSPC110172AAL59601.1in vitro;in vivo16148043   
79666PLEKHF215147NP_078889.1yeast 2-hybrid16189514   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd12946219-311  NOPS_p54nrb_PSF_PSPC1
cl06904219-311  eNOPS_SF superfamily
cd1258873-143  RRM1_p54nrb
cl1716973-143  RRM_SF superfamily
cd12947219-312  NOPS_p54nrb
cd12591149-228  RRM2_p54nrb
cl17169149-228  RRM_SF superfamily
cd12949219-312  NOPS_PSPC1
cd12333149-228  RRM2_p54nrb_like
cd12931219-308  eNOPS_SF
cd12948219-315  NOPS_PSF
cd12589149-228  RRM2_PSP1
cd1233273-143  RRM1_p54nrb_like
cd12590149-228  RRM2_PSF
cd1258773-143  RRM1_PSF
cd12945219-316  NOPS_NONA_like
pfam08075221-272  NOPS
cd1258673-143  RRM1_PSP1
cd0059076-142  RRM_SF
pfam0007676-140  RRM_1
cd1235476-142  RRM3_TIA1_like
cd1238274-141  RRM_RBMX_like
cd1241273-144  RRM_DAZL_BOULE
cd00590150-225  RRM_SF
cd1234375-141  RRM1_2_CoAA_like
pfam00076150-210  RRM_1
cd1260675-141  RRM1_RBM4
cd1231675-141  RRM3_RBM19_RRM2_MRD1
cd1239577-141  RRM2_RBM34
cd1237375-144  RRM_SRSF3_like
cd1239975-144  RRM_HP0827_like
cd1237175-141  RRM2_PUF60
cd1234174-139  RRM_hnRNPC_like
cd1238076-141  RRM3_I_PABPs
cd1231176-141  RRM_SRSF2_SRSF8
cd1236175-142  RRM1_2_CELF1-6_like
cd1245470-143  RRM2_RIM4_like
cd1235575-144  RRM_RBM18
cd1244975-147  RRM_CIRBP_RBM3
cd1222675-144  RRM_NOL8
cd1262274-140  RRM3_PUB1
cd1241874-143  RRM_Aly_REF_like
cd1231076-144  RRM3_Spen
cd1238976-144  RRM2_RAVER
cd1228476-141  RRM2_RBM23_RBM39
cd1222376-144  RRM_SR140
cd1256672-141  RRM2_MRD1
cd1239877-144  RRM_CSTF2_RNA15_like
cd1232274-114  RRM2_TDP43
cd1233875-143  RRM1_SRSF1_like
cd1235376-140  RRM2_TIA1_like
cd1239073-143  RRM3_RAVER
cd1230976-141  RRM2_Spen
cd1241376-144  RRM1_RBM28_like
cd1263375-144  RRM1_FCA
cd1231274-144  RRM_SRSF10_SRSF12
cd1241475-144  RRM2_RBM28_like
cd1259775-143  RRM1_SRSF1
cd1223175-144  RRM2_U2AF65
cd1222976-134  RRM_G3BP
cd1267476-144  RRM1_Nop4p
cd1252474-144  RRM1_MEI2_like
cd1256474-144  RRM1_RBM19
cd1256775-141  RRM3_RBM19
cd12384152-205  RRM_RBM24_RBM38_like
cd1233075-144  RRM2_Hrp1p
cd1234075-141  RBD_RRM1_NPL3
cd1261776-144  RRM2_TIAR
cd1239373-144  RRM_ZCRB1
cd1245075-144  RRM1_NUCLs
cd1238474-144  RRM_RBM24_RBM38_like
cd1260774-142  RRM2_RBM4
cd1234676-140  RRM3_NGR1_NAM8_like
cd1234776-141  RRM_PPIE
cd1236376-144  RRM_TRA2
cd1265276-144  RRM2_Hu
cd1223075-142  RRM1_U2AF65
cd1240878-135  RRM_eIF3G_like
cd1233775-144  RRM1_SRSF4_like
cd1265174-144  RRM2_SXL
cd1227275-141  RRM2_PHIP1
pfam1389391-144  RRM_5
cd1232775-118  RRM2_DAZAP1
cd1224976-147  RRM1_hnRNPR_like
cd1237574-144  RRM1_Hu_like
cd1239272-141  RRM2_SART3
cd1265073-144  RRM1_Hu
cd1225176-144  RRM3_hnRNPR_like
cd1241576-144  RRM3_RBM28_like
cd1222776-144  RRM_SCAF4_SCAF8
cd12415152-215  RRM3_RBM28_like
cd1237674-144  RRM2_Hu_like
cd1224476-144  RRM2_MSSP
cd1222476-142  RRM_RBM22
cd1236276-141  RRM3_CELF1-6
cd1240775-144  RRM_FOX1_like
cd1259975-141  RRM1_SF2_plant_like
cd12680148-205  RRM_THOC4
cd12414150-205  RRM2_RBM28_like
cd12251150-221  RRM3_hnRNPR_like
cd1233476-142  RRM1_SF3B4
cd1259875-143  RRM1_SRSF9
cd1242576-147  RRM4_PTBP1_like
cd1237776-143  RRM3_Hu
cd1255276-143  RRM_Nop15p
cd1232576-114  RRM1_hnRNPA_hnRNPD_like
cd1252376-114  RRM2_MRN1
cd1232176-115  RRM1_TDP43
cd12381150-204  RRM4_I_PABPs
cd12413149-206  RRM1_RBM28_like
cd1226576-134  RRM_SLT11
cd1260875-141  RRM1_CoAA
cd1238174-144  RRM4_I_PABPs
cd1267176-144  RRM_CSTF2_CSTF2T
cd1223776-145  RRM_snRNP35
cd1233676-142  RRM_RBM7_like
cd1241075-144  RRM2_RRT5
cd1244876-141  RRM2_gar2
cd12387152-206  RRM3_hnRNPM_like
cd12399150-206  RRM_HP0827_like
cd1263575-144  RRM2_CELF3_4_5_6
cd12674149-205  RRM1_Nop4p
cd1232375-123  RRM2_MSI
cd1244775-144  RRM1_gar2
cd12450149-205  RRM1_NUCLs
cd1261876-144  RRM2_TIA1
cd1259376-142  RRM_RBM11
cd1255676-143  RRM2_RBM15B
cd1267575-144  RRM2_Nop4p
cd1255974-144  RRM_SRSF10
cd1232875-114  RRM2_hnRNPA_like
cd1263275-109  RRM1_CELF3_4_5_6
cd1270374-144  RRM4_ROD1
cd1231574-144  RRM1_RBM19_MRD1
cd1233174-143  RRM_NRD1_SEB1_like
cd1264976-144  RRM1_SXL
cd12389150-204  RRM2_RAVER
cd1230776-142  RRM_NIFK_like
cd1257875-125  RRM1_hnRNPA_like
cd1224774-132  RRM2_U1A_like
cd1225074-144  RRM2_hnRNPR_like
cd12447150-206  RRM1_gar2
cd1235876-141  RRM1_VICKZ
cd12448150-206  RRM2_gar2
cd1260975-141  RRM2_CoAA
cd1237876-141  RRM1_I_PABPs
cd1248674-139  RRM1_ACF
cd1237976-141  RRM2_I_PABPs
cd1267374-141  RRM_BOULE
cd1235076-141  RRM3_SHARP
cd1236076-144  RRM_cwf2
cd12676147-205  RRM3_Nop4p
cd1242176-146  RRM1_PTBP1_hnRNPL_like
cd1276973-144  RRM1_HuR
cd1248476-135  RRM1_RBM46
cd1261976-141  RRM2_PUB1
cd1256574-144  RRM1_MRD1
cd12254150-208  RRM_hnRNPH_ESRPs_RBM12_like
cd12494150-206  RRM3_hnRNPR
cd12665150-204  RRM2_RAVER1
cd1259276-142  RRM_RBM7
cd1230677-141  RRM_II_PABPs
cd1264186-144  RRM_TRA2B
cd1224676-144  RRM1_U1A_like
cd1223476-144  RRM1_AtRSp31_like
cd1231876-143  RRM5_RBM19_like
cd12380152-206  RRM3_I_PABPs
cd1230584-144  RRM_NELFE
cd1240476-143  RRM2_NCL
cd12392150-205  RRM2_SART3
cd1224275-120  RRM_SLIRP
cd12386152-228  RRM2_hnRNPM_like
cd1239776-144  RRM2_Nop13p_fungi
cd1262176-136  RRM3_TIA1
cd1246375-134  RRM_G3BP1
cd1223576-143  RRM_PPIL4
cd1263775-144  RRM2_FCA
cd12316150-206  RRM3_RBM19_RRM2_MRD1
cd1255576-143  RRM2_RBM15
cd1263175-132  RRM1_CELF1_2_Bruno
cd12242152-205  RRM_SLIRP
cd1244675-141  RRM_RBM25
cd12449148-213  RRM_CIRBP_RBM3
cd1229774-134  RRM2_Prp24
cd1229373-109  RRM_Rrp7p
cd1229076-133  RRM1_LARP7
cd1232975-118  RRM2_hnRNPD_like
cd1229876-141  RRM3_Prp24
cd1257676-128  RRM1_MSI
cd1265676-148  RRM3_HuD
cd1224574-97  RRM_scw1_like
cd1277073-144  RRM1_HuD
cd1235772-114  RRM_PPARGC1A_like
cd1234476-145  RRM1_SECp43_like
cd1236576-142  RRM_RNPS1
cd1248576-139  RRM1_RBM47
cd1257074-144  RRM5_MRD1
cd1249476-144  RRM3_hnRNPR
cd12619149-206  RRM2_PUB1
cd1224176-98  RRM_SF3B14
cd1223676-117  RRM_snRNP70
cd12418150-207  RRM_Aly_REF_like
cd1257371-123  RRM2_MSI2
cd12367156-226  RRM2_RBM45
cd1272475-114  RRM1_CPEB2_like
cd1262076-136  RRM3_TIAR
cd12298152-205  RRM3_Prp24
cd1239476-141  RRM1_RBM34
cd12267152-207  RRM_YRA1_MLO3
cd1267676-159  RRM3_Nop4p
cd1267276-141  RRM_DAZL
cd1270176-144  RRM4_PTBP1
cd1223376-144  RRM_Srp1p_AtRSp31_like
cd1236773-125  RRM2_RBM45
cd1277173-144  RRM1_HuB
cd12566147-205  RRM2_MRD1
cd1261476-144  RRM1_PUB1
cd1239176-137  RRM1_SART3
cd1277574-144  RRM2_HuB
cd1238875-144  RRM1_RAVER
cd12376148-205  RRM2_Hu_like
cd1277674-144  RRM2_HuC
cd1277474-144  RRM2_HuD
cd12453147-226  RRM1_RIM4_like
cd1249576-144  RRM3_hnRNPQ
cd1255176-141  RRM_II_PABPN1L
cd1261276-144  RRM2_SECp43
cd1237074-141  RRM1_PUF60
cd1229677-117  RRM1_Prp24
cd12363150-208  RRM_TRA2
cd1257475-115  RRM1_DAZAP1
cd1241776-141  RRM_SAFB_like
cd1265476-143  RRM3_HuB
cd1258575-131  RRM2_hnRPDL
cd1240975-142  RRM1_RRT5
cd1240277-144  RRM_eIF4B
cd1232074-144  RRM6_RBM19_RRM5_MRD1
cd1270276-144  RRM4_PTBP2
cd1259575-144  RRM1_SRSF5
cd1242076-134  RRM_RBPMS_like
cd1257776-117  RRM1_Hrp1p
cd1235974-143  RRM2_VICKZ
cd1255874-144  RRM3_RBM15B
cd1263675-144  RRM2_Bruno_like
cd1238375-114  RRM_RBM42
cd12666150-204  RRM2_RAVER2
cd1277273-144  RRM1_HuC
cd1266776-143  RRM3_RAVER1
cd12379152-206  RRM2_I_PABPs
cd1255775-144  RRM3_RBM15
cd12284150-206  RRM2_RBM23_RBM39
cd1232672-114  RRM1_hnRNPA0
cd1257975-144  RRM2_hnRNPA0
cd12565152-217  RRM1_MRD1
cd1234576-144  RRM2_SECp43_like
cd12353152-206  RRM2_TIA1_like
cd1222863-118  RRM_ENOX
cd1224878-143  RRM_RBM44
cd1265576-143  RRM3_HuC
cd1266175-142  RRM3_hnRNPM
cd1240076-118  RRM_Nop6
cd1228176-98  RRM1_TatSF1_like
cd1266275-143  RRM3_MYEF2
cd12579150-204  RRM2_hnRNPA0
cd1259675-144  RRM1_SRSF6
cd1243476-144  RRM_RCAN_like
cd12495150-221  RRM3_hnRNPQ
cd12294150-224  RRM_Rrp7A
cd1228377-142  RRM1_RBM39_like
cd1246475-114  RRM_G3BP2
cd12405147-209  RRM3_NCL
cd1233576-144  RRM2_SF3B4
cd12391152-207  RRM1_SART3
cd12330152-205  RRM2_Hrp1p
cd1241176-141  RRM_ist3_like
cd1238776-142  RRM3_hnRNPM_like
cd1234275-139  RRM_Nab3p
cd1227176-142  RRM1_PHIP1
cd12675150-206  RRM2_Nop4p
cd1258075-117  RRM2_hnRNPA1
cd1226276-143  RRM2_4_MRN1
cd1229476-110  RRM_Rrp7A
cd1257275-123  RRM2_MSI1
cd1268074-143  RRM_THOC4
cd12328150-205  RRM2_hnRNPA_like
cd1266676-144  RRM2_RAVER2
cd1256074-144  RRM_SRSF12
cd1276272-114  RRM1_hnRNPA2B1
cd12335148-225  RRM2_SF3B4
cd12395152-205  RRM2_RBM34
cd1258175-117  RRM2_hnRNPA2B1
cd1248774-135  RRM1_DND1
cd1243676-141  RRM1_2_MATR3_like
cd1224376-125  RRM1_MSSP
cd1224076-135  RRM_NCBP2
cd1258375-141  RRM2_hnRNPD
cd1264575-144  RRM_SRSF3
cd1276372-114  RRM1_hnRNPA3
cd1234876-103  RRM1_SHARP
cd12390146-221  RRM3_RAVER
cd12308149-226  RRM1_Spen
cd12504153-210  RRM2_hnRNPH_like
cd1248274-141  RRM1_hnRNPR
smart0036075-141  RRM
TIGR0162876-253  PABP-1234
TIGR0162860-205  PABP-1234
COG072464-207  RRM
TIGR0162874-244  PABP-1234
TIGR0166173-205  ELAV_HUD_SF
TIGR0165974-205  sex-lethal
pfam1425976-140  RRM_6
smart00360152-206  RRM
TIGR0164257-148  U2AF_lg
TIGR0162275-157  SF-CC1
pfam14259150-208  RRM_6
TIGR0164876-233  hnRNP-R-Q
TIGR0165943-144  sex-lethal
TIGR0164875-222  hnRNP-R-Q
TIGR0162847-144  PABP-1234
TIGR0166142-144  ELAV_HUD_SF
PLN0313474-149  PLN03134
TIGR0164575-141  half-pint
TIGR0164272-142  U2AF_lg
TIGR0166176-148  ELAV_HUD_SF
TIGR0162263-205  SF-CC1
PLN03134147-205  PLN03134
pfam13851272-341  GAS
PRK12704238-336  PRK12704


Ontology Information


   
HPRD ID1906
Molecular ClassRNA binding protein
Molecular FunctionProtein binding (GO:0005515)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO