Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NPAS2 | 4862 | neuronal PAS domain protein 2 | 2 | MOP4, PASD4, bHLHe9 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24978311 | 2014 | Cell line : - Source : Department of General Surgery, the First Affiliated Hospital of Soochow University Sample Type : CRC tumor and normal tissue No. of Sample : 108 CRC patients Stage : TNM Stage I-IV | real time PCR, Flow cytometry, immunohistochemistry | Down-regulation | - | NPAS2, functioned as a potential tumor suppressor gene, could serve as a promising target and potential prognostic indicator for colorectal cancer. mRNA expressions of NPAS2 in 108 CRC patients by RT-PCR, and found that NPAS2 expression was significantly down-regulated in tumor tissues than that in NATs. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. |
| Chromosome | 2 |
| Location | 2q11.2 |
| Start | 100820151 |
| End | 100996827 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 176677 |
| OMIM ID | 603347 |
| HGNC ID | HGNC:7895 |
| Unigene ID | Hs.156832 |
| Ensembl ID | ENSG00000170485 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002518.3 |
|---|---|
| Exon | join(1..264,84583..84636,104996..105144,112760..112851, 117603..117692,128085..128205,129217..129330, 143908..144026,144711..144793,145510..145616, 148131..148278,150840..150924,154653..154794, 155308..155417,157560..157649,162081..162227, 167929..168126,170106..170296,170630..170722, 173197..173377,175250..176675) | mRNA Sequence | Download Select all |
| Length | 4004 |
CDS Information
| Location | join(877..1049,84583..84636,104996..105144,112760..112851, 117603..117692,128085..128205,129217..129330, 143908..144026,144711..144793,145510..145616, 148131..148278,150840..150924,154653..154794, 155308..155417,157560..157649,162081..162227, 167929..168126,170106..170296,170630..170722, 173197..173377,175250..175274,175646..175800) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_002509.2 |
|---|---|
| Protein Name | neuronal PAS domain protein 2 |
| Molecular Wt. (Da) | 91660 |
| Protein Sequence | Download Select all |
| Length | 824 |
| Uniprot ID | O15347 |
| Ensembl Protein ID | ENSP00000359393 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 406 | ARNTL | 3973 | NP_001169.3 | in vitro;in vivo;yeast 2-hybrid | 114 391 849 576 906 |
| 1387 | CREBBP | 2534 | NP_004371.2 | in vitro | 14645221 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro;in vivo | 14645221 |
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vivo | 9079689 |
| 5914 | RARA | 6769 | NP_000955.1 | in vitro;yeast 2-hybrid | 11439184 |
| 6256 | RXRA | 1577 | NP_002948.1 | in vitro;yeast 2-hybrid | 11439184 |
| 8202 | NCOA3 | 3570 | NP_858045.1 | in vitro | 14645221 |
| 8850 | KAT2B | 6780 | NP_003875.3 | in vitro | 14645221 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Circadian rhythm | hsa04710 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00130 | 250-350 | PAS |
| cl21578 | 250-350 | PAS superfamily |
| cd00083 | Jul-61 | HLH |
| cl00081 | Jul-61 | HLH superfamily |
| cd00130 | 93-159 | PAS |
| cl21578 | 93-159 | PAS superfamily |
| smart00091 | 84-149 | PAS |
| smart00353 | 15-65 | HLH |
| smart00091 | 246-305 | PAS |
| pfam00010 | Oct-58 | HLH |
| smart00086 | 311-352 | PAC |
| cl09965 | 311-352 | PAC superfamily |
| pfam14598 | 249-352 | PAS_11 |
| pfam08447 | 261-348 | PAS_3 |
| pfam00989 | 84-156 | PAS |
| pfam09606 | 454-792 | Med15 |
| TIGR00229 | 83-146 | sensory_box |
| pfam03154 | 563-772 | Atrophin-1 |
| pfam03154 | 717-824 | Atrophin-1 |
| pfam03154 | 422-759 | Atrophin-1 |
| COG3266 | 632-755 | DamX |
Ontology Information
| HPRD ID | 4067 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | MRNA binding (GO:0003729) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.