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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NRCAM 4897 neuronal cell adhesion molecule  7KIAA0343, Bravo 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21718388   2011Cell line : -

Source : National University Hospital of Singapore.

Sample Type : CRC tumor

No. of Sample : 428

Stage : TNM Stage II-IV

Immunohistochemistry, tissue microarraysUp-regulation-Nr-CAM overexpression is an independent marker of poor prognosis among advanced CRC patients.


Gene Details



NC_000007.13 (107788071..108096841, complement)

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Gene Type protein coding
Gene Family Immunoglobulin superfamily / I-set domain containing, "Immunoglobulin superfamily / Immunoglobulin-like domain containing", "Fibronectin type III domain containing"
Description Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]  
Chromosome 7
Location 7q31
Start 107788071  
End 108096841  
Strand -  
Gene Sequence

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Length 308771  
OMIM ID 601581   
HGNC ID HGNC:7994   
Unigene ID Hs.21422   
Ensembl ID ENSG00000091129   
PharmGKB ID PA31773   

mRNA Information


mRNA ID NM_005010.4
Exon join(1..155,56805..56962,143667..143733,216228..216439, 221710..221815,223876..224072,225245..225367, 230020..230190,230697..230753,232562..232673, 246793..246977,248739..248870,258299..258442, 260526..260637,261970..262136,262227..262374, 264545..264669,266652..266753,271784..271981, 272087..272157,273478..273703,274461..274576, 275971..276175,278286..278408,279792..279968, 295906..296037,296857..296935,306251..308772)  
mRNA Sequence

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Length 6322  



CDS Information


   
Location 487..4038
CDS Sequence

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CCDS ID CCDS47686.1



Protein Information


      
Protein IDNP_005001.3
Protein Nameneuronal cell adhesion molecule
Molecular Wt. (Da)0
Protein Sequence

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Length 1183  
Uniprot IDP56703
Ensembl Protein ID ENSP00000225512  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
287ANK2110NP_001139.3in vitro11449000   
5787PTPRB1474NP_001103224.1in vivo9049255   
6900CNTN21826NP_005067.1in vitro12139915   


Pathway Information


      
Pathway Name Pathway ID
Cell adhesion molecules (CAMs) hsa04514


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd05868375-450  Ig4_NrCAM
cl11960375-450  Ig superfamily
cd0587464-140  Ig6_NrCAM
cl1196064-140  Ig superfamily
cd00063647-737  FN3
cl21522647-737  FN3 superfamily
cd00063952-1047  FN3
cl21522952-1047  FN3 superfamily
cd00063848-947  FN3
cl21522848-947  FN3 superfamily
cd00096472-539  Ig
cl11960472-539  Ig superfamily
cd00063749-828  FN3
cl21522749-828  FN3 superfamily
cd000631067-1143  FN3
cl215221067-1143  FN3 superfamily
cd0573364-140  Ig6_L1-CAM_like
pfam138821191-1282  Bravo_FIGEY
cl164511191-1282  Bravo_FIGEY superfamily
cd04978375-450  Ig4_L1-NrCAM_like
cd05731288-358  Ig3_L1-CAM_like
cl11960288-358  Ig superfamily
cd05845145-237  Ig2_L1-CAM_like
cl11960145-237  Ig superfamily
cd0587564-140  Ig6_hNeurofascin_like
cd05876288-358  Ig3_L1-CAM
cd05867375-450  Ig4_L1-CAM_like
pfam00041649-733  fn3
cd0769345-136  Ig1_Robo
pfam00041848-940  fn3
cd07693360-439  Ig1_Robo
pfam00041953-1037  fn3
smart00060647-730  FN3
cd05728363-449  Ig4_Contactin-2-like
smart00060952-1037  FN3
cd04967373-443  Ig1_Contactin
cd05725290-357  Ig3_Robo
smart00060848-937  FN3
cd0584851-140  Ig1_Contactin-5
cd00096379-445  Ig
cd05729285-357  Ig2_FGFR_like
cd0572253-134  Ig1_Neogenin
cd00096288-354  Ig
cd0496751-134  Ig1_Contactin
cd04968283-347  Ig3_Contactin_like
cd05848361-443  Ig1_Contactin-5
cd04970566-636  Ig6_Contactin_like
cl11960566-636  Ig superfamily
cd05764285-357  Ig_2
cd05733379-444  Ig6_L1-CAM_like
cd05850373-439  Ig1_Contactin-2
cd05738379-439  Ig2_RPTP_IIa_LAR_like
pfam1389552-137  Ig_2
cd00096563-630  Ig
cd05856285-357  Ig2_FGFRL1-like
cd0497862-135  Ig4_L1-NrCAM_like
cd0009664-130  Ig
cd05725563-633  Ig3_Robo
pfam13895363-439  Ig_2
pfam13927278-344  Ig_3
cd05729380-439  Ig2_FGFR_like
cd05730375-452  Ig3_NCAM-1_like
pfam00041750-832  fn3
cd05724367-439  Ig2_Robo
cd05736379-439  Ig2_Follistatin_like
cd05854563-636  Ig6_Contactin-2
cd05728285-357  Ig4_Contactin-2-like
cd05764470-542  Ig_2
cd0585060-140  Ig1_Contactin-2
cd05743285-349  Ig_Perlecan_D2_like
cd05728547-633  Ig4_Contactin-2-like
cd04969473-542  Ig5_Contactin_like
cd04973552-624  Ig1_FGFR
pfam13927548-620  Ig_3
cd0496964-139  Ig5_Contactin_like
cd05857285-357  Ig2_FGFR
cd05736289-347  Ig2_Follistatin_like
pfam000411067-1144  fn3
cd0572851-135  Ig4_Contactin-2-like
cd05724459-532  Ig2_Robo
cd05724551-633  Ig2_Robo
cd04969285-347  Ig5_Contactin_like
cd05731473-543  Ig3_L1-CAM_like
cd05851283-358  Ig3_Contactin-1
cd0586862-138  Ig4_NrCAM
cd07693284-347  Ig1_Robo
cd05746288-347  Ig4_Peroxidasin
cd05745285-348  Ig3_Peroxidasin
cd05763290-349  Ig_1
cd07693453-534  Ig1_Robo
cd0574567-131  Ig3_Peroxidasin
cd05754549-632  Ig3_Perlecan_like
cd05743375-444  Ig_Perlecan_D2_like
cd05856380-449  Ig2_FGFRL1-like
cd0572363-134  Ig4_Neogenin
cd05763380-450  Ig_1
smart000601067-1143  FN3
cd05728475-532  Ig4_Contactin-2-like
smart00060749-828  FN3
pfam1392745-127  Ig_3
cd05730285-359  Ig3_NCAM-1_like
cd05875473-541  Ig6_hNeurofascin_like
cd05723290-350  Ig4_Neogenin
pfam00047285-342  ig
cd05735285-361  Ig8_DSCAM
cd0585264-139  Ig5_Contactin-1
cd04967265-349  Ig1_Contactin
pfam13927364-436  Ig_3
cd05722362-437  Ig1_Neogenin
cd05746578-632  Ig4_Peroxidasin
cd05736472-544  Ig2_Follistatin_like
cd04968474-532  Ig3_Contactin_like
cd05730473-542  Ig3_NCAM-1_like
cd05724278-348  Ig2_Robo
cd05733473-540  Ig6_L1-CAM_like
pfam00047560-618  ig
cd05739285-355  Ig3_RPTP_IIa_LAR_like
cd05738292-347  Ig2_RPTP_IIa_LAR_like
cd0574362-130  Ig_Perlecan_D2_like
cd0573045-132  Ig3_NCAM-1_like
cd05740276-350  Ig_CEACAM_D4
cd0572451-135  Ig2_Robo
cd07693548-634  Ig1_Robo
cd0576366-135  Ig_1
cd05748474-540  Ig_Titin_like
cd05875382-444  Ig6_hNeurofascin_like
cd05722471-530  Ig1_Neogenin
cd05760288-349  Ig2_PTK7
cd05747453-542  Ig5_Titin_like
cd05746474-540  Ig4_Peroxidasin
cd05722283-349  Ig1_Neogenin
cd05857382-439  Ig2_FGFR
pfam00047474-527  ig
pfam13895551-633  Ig_2
cd05874382-447  Ig6_NrCAM
cd05737285-355  Ig_Myomesin_like_C
cd05747364-401  Ig5_Titin_like
cd05757576-618  Ig2_IL1R_like
cd05731578-626  Ig3_L1-CAM_like
cd05849379-439  Ig1_Contactin-1
cd05730578-635  Ig3_NCAM-1_like
cd0586762-135  Ig4_L1-CAM_like
pfam13927477-529  Ig_3
cd05748296-357  Ig_Titin_like
cd05873285-355  Ig_Sema4D_like
cd05750288-347  Ig_Pro_neuregulin
cd05729474-542  Ig2_FGFR_like
cd04974560-633  Ig3_FGFR
cd04976579-617  Ig2_VEGFR
pfam07686545-633  V-set
pfam08205363-424  C2-set_2
cd05763472-532  Ig_1
cd05773371-439  Ig8_hNephrin_like
cd04978560-634  Ig4_L1-NrCAM_like
cd05857463-542  Ig2_FGFR
cd05852285-352  Ig5_Contactin-1
cd05726375-449  Ig4_Robo
cd05723473-542  Ig4_Neogenin
cd05848288-349  Ig1_Contactin-5
cd05851375-449  Ig3_Contactin-1
cd05732279-347  Ig5_NCAM-1_like
cd04979556-618  Ig_Semaphorin_C
cd05754364-445  Ig3_Perlecan_like
cd05853567-636  Ig6_Contactin-4
cd05852473-542  Ig5_Contactin-1
pfam13895284-344  Ig_2
cd0577359-143  Ig8_hNephrin_like
cd04969560-633  Ig5_Contactin_like
cd05740379-437  Ig_CEACAM_D4
cd04969382-439  Ig5_Contactin_like
pfam13895456-540  Ig_2
cd07702579-617  Ig2_VEGFR-1
cd05876474-535  Ig3_L1-CAM
cd05763597-634  Ig_1
cd05745476-542  Ig3_Peroxidasin
cd05737474-538  Ig_Myomesin_like_C
cd05734290-348  Ig7_DSCAM
cd05867472-542  Ig4_L1-CAM_like
cd04968375-439  Ig3_Contactin_like
cd0572564-132  Ig3_Robo
cd0574871-140  Ig_Titin_like
cd05891474-538  Ig_M-protein_C
cd0573666-130  Ig2_Follistatin_like
cd04976296-344  Ig2_VEGFR
cd05729560-618  Ig2_FGFR_like
cd05744288-347  Ig_Myotilin_C_like
cd05734473-539  Ig7_DSCAM
cd0576064-135  Ig2_PTK7
cd05864296-344  Ig2_VEGFR-2
cd05745382-449  Ig3_Peroxidasin
cd05723563-633  Ig4_Neogenin
cd05757299-359  Ig2_IL1R_like
pfam0004762-125  ig
smart00408285-347  IGc2
pfam07679361-449  I-set
pfam07679548-633  I-set
pfam07679454-542  I-set
smart0041053-139  IG_like
smart00410153-238  IG_like
smart00409367-449  IG
smart00410367-449  IG_like
smart00410552-633  IG_like
smart00409552-633  IG
smart00408469-532  IGc2
smart00410285-357  IG_like
smart00409285-357  IG
pfam0767946-132  I-set
smart00408374-439  IGc2
smart00410464-542  IG_like
smart00409464-542  IG
pfam07679268-357  I-set
smart0040953-139  IG
smart00408560-618  IGc2
PHA02785508-634  PHA02785
smart0040862-130  IGc2
smart00409153-238  IG


Ontology Information


   
HPRD ID5233
Molecular ClassAdhesion molecule
Molecular FunctionReceptor binding (GO:0005102)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO