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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| YBX1 | 4904 | Y box binding protein 1 | 1 | YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 10597187 | 1999 | Cell line : - Source : Department of Surgery I, University of Occupational and Environmental Health, School of Medicine. Sample Type : - No. of Sample : 26 CRC patients Stage : - | Western blotting, Northern blotting and immunohistochemistry | Up-regulation | - | YB-1 may be an excellent proliferation-associated marker and may be a transcription factor regulating DNA topoisomerase II alpha gene expression in human colorectal carcinoma. YB-1 was overexpressed in almost all cancerous lesions in comparison with normal mucosa in surgically resected colorectal carcinomas of 26 patients. |
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : - No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis and using spectral counting combined with statistics | Up-regulation | - | YBX1 acts as the transcriptional regulator hnRNPD, and the transcriptional activator ATP-dependent RNA helicase A (DHX9).
|
| 21170361 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, GO analysis, EMSA, Microarray analysis, Proliferation assays, Gel shift, and chromatin immunoprecepetation | Up-regulation | - | MEK/ERK-dependent, YBX1-regulated target genes are involved in executing malignant properties. The colon carcinoma cell lines SW480, HT29 and HCT116 cell lines used. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - |
| Chromosome | 1 |
| Location | 1p34 |
| Start | 42682389 |
| End | 42702363 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 19975 |
| OMIM ID | 154030 |
| HGNC ID | HGNC:8014 |
| Unigene ID | Hs.473583 |
| Ensembl ID | ENSG00000065978 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005270904.2 |
|---|---|
| Exon | join(1..343,1015..1078,11102..11135,14254..14556, 14792..14874,18393..18658,19593..19975) | mRNA Sequence | Download Select all |
| Length | 1561 |
CDS Information
| Location | join(178..343,1015..1078,11102..11135,13811..13900, 14254..14556,14792..14874,18393..18627) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS470.1 |
Protein Information
| Protein ID | NP_004550.2 |
|---|---|
| Protein Name | Y box binding protein 1 |
| Molecular Wt. (Da) | 35793 |
| Protein Sequence | Download Select all |
| Length | 324 |
| Uniprot ID | Q13286 |
| Ensembl Protein ID | ENSP00000329171 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 102 |
| Y | Phosphorylation | 162;- |
| S | Phosphorylation | 174;- |
| S | Phosphorylation | 167;- |
| S | Phosphorylation | 176;- |
| S | Phosphorylation | 165;- |
| Y | Phosphorylation | 158 |
| S | Phosphorylation | 314 |
| S | Phosphorylation | 313 |
| S | Acetylation | 2 |
| S | Phosphorylation | 2 |
| K | Acetylation | 81 |
| T | Phosphorylation | 7 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2521 | FUS | 660 | NP_004951.1 | in vitro;yeast 2-hybrid | 12168660 |
| 2932 | GSK3B | 5418 | NP_002084.2 | in vitro | 16198352 |
| 4088 | SMAD3 | 4380 | NP_005893.1 | in vitro;in vivo | 12917425 |
| 5594 | MAPK1 | 1496 | NP_002736.3 | in vitro | 16198352 |
| 6532 | SLC6A4 | 1640 | NP_001036.1 | in vitro;in vivo;yeast 2-hybrid | 15229244 |
| 7020 | TFAP2A | 128 | NP_003211.1 | in vitro;in vivo | 983 004 711 973 333 |
| 8683 | SFRS9 | 9053 | NP_003760.1 | in vivo;yeast 2-hybrid | 12604611 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04458 | 61-127 | CSP_CDS |
| cl09927 | 61-127 | S1_like superfamily |
| pfam00313 | 59-128 | CSD |
| smart00357 | 61-128 | CSP |
| COG1278 | 61-126 | CspC |
| PRK09507 | 57-126 | cspE |
| PRK09890 | 55-125 | PRK09890 |
| PRK10354 | 55-126 | PRK10354 |
| TIGR02381 | 61-125 | cspD |
| PRK10943 | 58-126 | PRK10943 |
| PRK09937 | 61-134 | PRK09937 |
| PRK14998 | 60-139 | PRK14998 |
| PRK15463 | 55-125 | PRK15463 |
Ontology Information
| HPRD ID | 5324 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.