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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NT5E | 4907 | 5'-nucleotidase, ecto (CD73) | 6 | NT; eN; NT5; NTE; eNT; CD73; E5NT |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22930170 | 2012 | Cell line : KM 12C, KM 12SM, HT 29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Microarray analysis,Real time RT-PCR and Flow cytometry | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. |
| 22287455 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Immunohistochemistry, Western blotting and tissue microarrays. | Up-regulation | - | High expression of CD73 can be an independent and useful biomarker for predicting the poor survival of patients with CRC. Western blotting analysis demonstrated that CD73 expression in CRC was significantly higher than in normal colorectal tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] |
| Chromosome | 6 |
| Location | 6q14-q21 |
| Start | 85449584 |
| End | 85495791 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 46208 |
| OMIM ID | 129190 |
| HGNC ID | HGNC:8021 |
| Unigene ID | Hs.153952 |
| Ensembl ID | ENSG00000135318 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002526.3 |
|---|---|
| Exon | join(1..895,17477..17699,21654..21842,35652..35849, 37752..37906,39911..40016,40925..41074,42394..42594, 44258..46208) | mRNA Sequence | Download Select all |
| Length | 4086 |
CDS Information
| Location | join(557..895,17477..17699,21654..21842,35652..35849, 37752..37906,39911..40016,40925..41074,42394..42594, 44258..44421) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5002.1 |
Protein Information
| Protein ID | NP_001191742.1 |
|---|---|
| Protein Name | 5'-nucleotidase, ecto (CD73) |
| Molecular Wt. (Da) | 55405 |
| Protein Sequence | Download Select all |
| Length | 524 |
| Uniprot ID | P09496 |
| Ensembl Protein ID | ENSP00000242285 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Glycosyl phosphatidyl inositol GPI | 549 |
| N | Glycosylation | 333 |
Enzyme Information
| EC | 3.1.3.5 |
|---|---|
| Name | 5'-nucleotidase uridine 5'-nucleotidase 5'-adenylic phosphatase adenosine 5'-phosphatase AMP phosphatase adenosine monophosphatase 5'-mononucleotidase AMPase UMPase snake venom 5'-nucleotidase thimidine monophosphate nucleotidase 5'-AMPase 5'-AMP nucleotidase AMP phosphohydrolase IMP 5'-nucleotidase |
| Class | Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases |
| Sysname | 5'-ribonucleotide phosphohydrolase |
| Substrate | 5'-ribonucleotide [CPD:C02520]; H2O |
| Product | ribonucleoside [CPD:C00911]; phosphate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 60 | ACTB | 32 | NP_001092.1 | in vivo | 10470109 |
| 2335 | FN1 | 626 | NP_997647.1 | in vivo | 936 179 510 470 109 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolic pathways | hsa01100 |
| Nicotinate and nicotinamide metabolism | hsa00760 |
| Purine metabolism | hsa00230 |
| Pyrimidine metabolism | hsa00240 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07409 | 29-310 | MPP_CD73_N |
| cl13995 | 29-310 | MPP_superfamily superfamily |
| cd00845 | 29-310 | MPP_UshA_N_like |
| pfam02872 | 339-513 | 5_nucleotid_C |
| cl03752 | 339-513 | 5_nucleotid_C superfamily |
| cd07410 | 29-296 | MPP_CpdB_N |
| cd07408 | 30-222 | MPP_SA0022_N |
| cd07405 | 29-312 | MPP_UshA_N |
| cd07411 | 29-298 | MPP_SoxB_N |
| cd07406 | 29-232 | MPP_CG11883_N |
| cd08162 | 29-307 | MPP_PhoA_N |
| cd07412 | 29-303 | MPP_YhcR_N |
| pfam00149 | 29-222 | Metallophos |
| cd07407 | 28-119 | MPP_YHR202W_N |
| COG0737 | 11-532 | UshA |
| PRK09419 | 22-547 | PRK09419 |
| TIGR01530 | 29-548 | nadN |
| PRK09558 | 10-538 | ushA |
| PRK09419 | 29-544 | PRK09419 |
| TIGR04486 | 58-369 | thiosulf_SoxB |
| PRK09418 | 29-294 | PRK09418 |
| PRK11907 | 28-227 | PRK11907 |
| PRK09420 | 10-144 | cpdB |
| TIGR01390 | 28-226 | CycNucDiestase |
Ontology Information
| HPRD ID | 3223 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P21589 | DB00987 | Cytarabine | SmallMoleculeDrug |
| P21589 | DB00806 | Pentoxifylline | SmallMoleculeDrug |