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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NTHL1 | 4913 | nth endonuclease III-like 1 (E. coli) | 16 | NTH1, OCTS3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25938944 | 2015 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 51 Stage : - | Whole exome sequencing | Mutation | - | Homozygous loss-of-function germline mutation in the NTHL1 gene predisposes to a new subtype of BER-associated adenomatous polyposis and CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008] |
| Chromosome | 16 |
| Location | 16p13.3 |
| Start | 2089816 |
| End | 2097931 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8116 |
| OMIM ID | 602656 |
| HGNC ID | HGNC:8028 |
| Unigene ID | Hs.66196 |
| Ensembl ID | ENSG00000065057 |
| PharmGKB ID | PA31811 |
mRNA Information
| mRNA ID | NM_002528.6 |
|---|---|
| Exon | join(1..158,1501..1739,3067..3237,4141..4300,7629..7734, 7820..8052) | mRNA Sequence | Download Select all |
| Length | 1100 |
Protein Information
| Protein ID | NP_002519.1 |
|---|---|
| Protein Name | nth endonuclease III-like 1 (E. coli) |
| Molecular Wt. (Da) | 43065 |
| Protein Sequence | Download Select all |
| Length | 312 |
| Uniprot ID | P41221 |
| Ensembl Protein ID | ENSP00000264634 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 68 |
| S | Phosphorylation | 73 |
| S | Phosphorylation | 71 |
| S | Phosphorylation | 135 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2073 | ERCC5 | 595 | NP_000114.2 | in vitro | 9927729 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Base excision repair | hsa03410 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00056 | 130-286 | ENDO3c |
| cl22429 | 130-286 | ENDO3c superfamily |
| smart00478 | 138-287 | ENDO3c |
| TIGR01083 | 130-297 | nth |
| pfam00730 | 134-272 | HhH-GPD |
| pfam00633 | 199-223 | HHH |
| smart00525 | 289-309 | FES |
| cl23355 | 289-309 | FES superfamily |
| COG2987 | 193-270 | HutU |
| cl19311 | 193-270 | Urocanase superfamily |
| COG0177 | 129-310 | Nth |
| PRK10702 | 130-306 | PRK10702 |
| COG1194 | 130-311 | MutY |
| COG2231 | 129-290 | COG2231 |
| TIGR01084 | 130-310 | mutY |
| TIGR00588 | 185-280 | ogg |
| COG0122 | 130-276 | AlkA |
Ontology Information
| HPRD ID | 3341 |
|---|---|
| Molecular Class | Deoxyribonuclease |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.