Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| OGG1 | 4968 | 8-oxoguanine DNA glycosylase | 3 | HMMH, HOGG1, OGH1, MUTM |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25268610 | 2014 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 49 Stage : TNM Stage I-IV | Genotyping | Down-regulation | - | Colorectal cancer present expression changes in several BER genes, suggesting a role for APE1, XRCC1, PARP1 and OGG1 and APE1 polymorphism in colorectal carcinogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008] |
| Chromosome | 3 |
| Location | 3p26 |
| Start | 9791628 |
| End | 9829468 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 37841 |
| OMIM ID | 601982 |
| HGNC ID | HGNC:8125 |
| Unigene ID | Hs.380271 |
| Ensembl ID | ENSG00000114026 |
| PharmGKB ID | PA31912 |
mRNA Information
| mRNA ID | NM_016828.2 |
|---|---|
| Exon | join(1..480,1002..1249,1827..2006,4761..4942,6528..6678, 6824..6873,9244..9343,15866..16726) | mRNA Sequence | Download Select all |
| Length | 2258 |
Protein Information
| Protein ID | NP_058437.1 |
|---|---|
| Protein Name | 8-oxoguanine DNA glycosylase |
| Molecular Wt. (Da) | 15306 |
| Protein Sequence | Download Select all |
| Length | 356 |
| Uniprot ID | O96014 |
| Ensembl Protein ID | ENSP00000325526 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5578 | PRKCA | 1498 | NP_002728.1 | in vivo | 12034821 |
| 7515 | XRCC1 | 1909 | NP_006288.2 | in vitro;yeast 2-hybrid | 12933815 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Base excision repair | hsa03410 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00056 | 139-319 | ENDO3c |
| cl22429 | 139-319 | ENDO3c superfamily |
| pfam07934 | 25-141 | OGG_N |
| cl05528 | 25-141 | AlkA_N superfamily |
| smart00478 | 146-315 | ENDO3c |
| pfam00730 | 143-309 | HhH-GPD |
| TIGR01083 | 181-332 | nth |
| TIGR00588 | 11-328 | ogg |
| COG0122 | 93-333 | AlkA |
| COG0177 | 132-277 | Nth |
| TIGR01084 | 181-265 | mutY |
| COG1194 | 181-268 | MutY |
| PRK10702 | 192-277 | PRK10702 |
Ontology Information
| HPRD ID | 5212 |
|---|---|
| Molecular Class | DNA repair protein |
| Molecular Function | Deoxyribonuclease activity (GO:0004536) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.