Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | 8 | OCIF, TR1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21270110 | 2011 | Cell line : - Source : Tokyo Medical and Dental University Hospital Sample Type : CRC tumor and normal tissue No. of Sample : 378 Stage : TNM Stage I-IV | Microarray, Quantitative RT-PCR, Immunohistochemistry | Up-regulation | - | Overexpression of OPG may be a predictive biomarker of CRC recurrence and a target for treatment of this disease. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Tumor necrosis factor receptor superfamily |
| Description | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. |
| Chromosome | 8 |
| Location | 8q24 |
| Start | 118923557 |
| End | 118952144 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 28588 |
| OMIM ID | 602643 |
| HGNC ID | HGNC:11909 |
| Unigene ID | Hs.81791 |
| Ensembl ID | ENSG00000164761 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002546.3 |
|---|---|
| Exon | join(1..353,18845..19214,23216..23407,25427..25651, 27383..28588) | mRNA Sequence | Download Select all |
| Length | 2354 |
CDS Information
| Location | join(324..353,18845..19214,23216..23407,25427..25651, 27383..27771) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6326.1 |
Protein Information
| Protein ID | NP_002537.3 |
|---|---|
| Protein Name | tumor necrosis factor receptor superfamily, member 11b |
| Molecular Wt. (Da) | 43617 |
| Protein Sequence | Download Select all |
| Length | 401 |
| Uniprot ID | P17096 |
| Ensembl Protein ID | ENSP00000308227 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2335 | FN1 | 626 | NP_997647.1 | in vivo | 15799029 |
| 7057 | THBS1 | 1765 | NP_003237.2 | in vivo | 15799029 |
| 7448 | VTN | 1902 | NP_000629.3 | in vivo | 15799029 |
| 7450 | VWF | 1906 | NP_000543.2 | in vivo | 15799029 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Osteoclast differentiation | hsa04380 |
Structure Information
| PDB ID | 3URF |
|---|---|
| Resolution | 2.7 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | Tumor necrosis factor ligand superfamily member 11, soluble form |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10581 | 6-152 | TNFRSF11B |
| cl22855 | 6-152 | TNFRSF superfamily |
| cd01670 | 323-353 | Death |
| cl14633 | 323-353 | DD superfamily |
| cd10575 | 26-186 | TNFRSF6B |
| cd10577 | 30-186 | TNFRSF1B |
| cd13412 | 25-148 | TNFRSF11B_teleost |
| cd10583 | 27-185 | TNFRSF21 |
| cd13407 | 41-185 | TNFRSF5 |
| cd13416 | 41-167 | TNFRSF16 |
| cd13411 | 41-186 | TNFRSF11A |
| cd15835 | 39-142 | TNFRSF1B_teleost |
| cd13422 | 41-185 | TNFRSF5_teleost |
| cd00185 | 41-126 | TNFRSF |
| cd15834 | 41-168 | TNFRSF1A_teleost |
| cd15839 | 36-146 | TNFRSF_viral |
| cd13406 | 32-189 | TNFRSF4 |
| cd15837 | 32-142 | TNFRSF26 |
| cd13405 | 41-127 | TNFRSF14_teleost |
| cd10580 | 41-142 | TNFRSF10 |
| cd10578 | 34-127 | TNFRSF3 |
| cd15836 | 41-145 | TNFRSF11A_teleost |
| cd10579 | 37-143 | TNFRSF6 |
| cd10576 | 27-150 | TNFRSF1A |
| cd13410 | 36-186 | TNFRSF9 |
| cd13424 | 41-185 | TNFRSF9_teleost |
| cd13417 | 105-186 | TNFRSF18 |
| cd13416 | 26-105 | TNFRSF16 |
| cd13419 | 124-187 | TNFRSF19L |
| cl22855 | 124-187 | TNFRSF superfamily |
| cd00185 | 122-185 | TNFRSF |
| pfam00531 | 293-365 | Death |
| cd13423 | 41-112 | TNFRSF6_teleost |
| cd10582 | 41-111 | TNFRSF14 |
| smart00208 | 107-142 | TNFR |
| pfam00020 | 65-105 | TNFR_c6 |
| cd13405 | 124-185 | TNFRSF14_teleost |
| smart00208 | 65-105 | TNFR |
| PHA02637 | 32-96 | PHA02637 |
| cl22868 | 32-96 | PHA02637 superfamily |
| smart00208 | 32-62 | TNFR |
| smart00005 | 277-351 | DEATH |
| cd10578 | 99-146 | TNFRSF3 |
| cd13420 | 41-114 | TNFRSF25 |
| cd13419 | 116-160 | TNFRSF19L |
| cd15838 | 41-112 | TNFRSF27 |
| cd10582 | 107-185 | TNFRSF14 |
Ontology Information
| HPRD ID | 3818 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Ribonucleoprotein (GO:0003733) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.