Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PEBP1 5037 phosphatidylethanolamine binding protein 1  12RKIP, HCNP, PEBP 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23632477   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 220

Stage : -

Tissue microarrayDown-regulation-The clinical relevance of RKIP expression as an independent prognostic factor is restricted to the tumour centre.

Loss of RKIP predicts features of EMT and correlates with frequent distant metastasis.

Whole-tissue sections of 220 well-characterised CRCs were immunostained for RKIP.

23460950   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 220 patients

Stage : Duke stage B

Tissue microarray, pyrosequencingDown-regulation-RKIP is potential in identifying 'high-risk' Dukes'B patients.It is this high-risk group which is most likely to benefit from close postoperative monitoring and may derive the most benefit from adjuvant therapy.


Gene Details



Chromosome 12 - NC_000012.12 (118136065..118145585)

View Larger Image
   
Gene Type protein coding
Gene Family
Description -  
Chromosome 12
Location 12q24
Start 118136065  
End 118145585  
Strand +  
Gene Sequence

   Download   Select all

Length 9521  
OMIM ID 604591   
HGNC ID HGNC:8630   
Unigene ID Hs.433863   
Ensembl ID ENSG00000089220   
PharmGKB ID -   

mRNA Information


mRNA ID NM_002567.2
Exon join(1..280,1975..2084,3387..3487,8522..9521)  
mRNA Sequence

   Download   Select all

Length 1507  



CDS Information


   
Location join(146..280,1975..2084,3387..3487,8522..8739)
CDS Sequence

   Download   Select all

CCDS ID CCDS9187.1



Protein Information


      
Protein IDNP_002558.1
Protein Namephosphatidylethanolamine binding protein 1
Molecular Wt. (Da)20926
Protein Sequence

   Download   Select all

Length 187  
Uniprot IDQ99729
Ensembl Protein ID ENSP00000348093  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation153
SPhosphorylation153
SPhosphorylation153
SPhosphorylation153
SPhosphorylation153
SPhosphorylation52;-
TPhosphorylation42
TPhosphorylation51
SPhosphorylation54
SPhosphorylation99
YPhosphorylation120
YPhosphorylation125

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5594MAPK11496NP_002736.3in vitro;in vivo1   075   779   210   490   020   
5604MAP2K11469NP_002746.1in vitro;in vivo10757792   
5894RAF11265NP_002871.1in vitro17097642   
6885MAP3K74011NP_663304.1in vivo11585904   
8614STC24717NP_003705.1yeast 2-hybrid16169070   
57685CACHD113874NP_065976.2yeast 2-hybrid12421765   
84246MED1014680NP_115662.2yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0086623-171  PEBP_euk
cl0022723-171  PEBP superfamily
pfam0116122-170  PBP
cd0045734-171  PEBP
PLN0016925-165  PLN00169
COG188153-136  PEBP
cd0086553-125  PEBP_bact_arch
TIGR0048152-130  TIGR00481
PRK0981838-143  PRK09818


Ontology Information


   
HPRD ID849
Molecular ClassProtease inhibitor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO