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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20715105 | 2011 | Cell line : - Source : Steven F. Moss, M.D. and Lelia Simao (Rhode Island Hospital, Providence, RI). Sample Type : CRC tumor and normal tissue No. of Sample : 10 Stage : - | real time RT-PCR, Immunoblotting, Immunohistochemistry, Cell culture, siRNA transfection and LPS treatment, | Up-regulation | - | Nox1 and Nox4 mRNA and protein levels were markedly elevated in a panel of primary human colon cancers, compared with their matched controls. |
| 21922590 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 60 Stage : - | - | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009] |
| Chromosome | 11 |
| Location | 11q14.2-q2 |
| Start | 89324353 |
| End | 89589611 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 265259 |
| OMIM ID | 605261 |
| HGNC ID | HGNC:7891 |
| Unigene ID | Hs.371036 |
| Ensembl ID | ENSG00000086991 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001143837.1 |
|---|---|
| Exon | join(1..172,42917..42975,91425..91615,97393..97491, 99059..99154,137717..137827,140088..140172,145380..145477, 148897..148924,156756..156828,167630..167710, 187070..187286,189233..189397,189533..189595, 216120..216180,234569..234650,247419..247538, 249441..249549,252097..252165,253667..253767, 262736..265259) | mRNA Sequence | Download Select all |
| Length | 4615 |
CDS Information
| Location | join(98366..98422,99059..99154,137717..137827, 140088..140172,145380..145477,148897..148924, 156756..156828,167630..167710,187070..187286, 189233..189397,189533..189595,216120..216180, 234569..234650,249441..249549,252097..252165, 253667..253767,262736..262856) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS44695.1 |
Protein Information
| Protein ID | NP_001278856.1 |
|---|---|
| Protein Name | NADPH oxidase 4 |
| Molecular Wt. (Da) | 69542 |
| Protein Sequence | Download Select all |
| Length | 599 |
| Uniprot ID | P35556 |
| Ensembl Protein ID | ENSP00000262464 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 1.6.3.1 |
|---|---|
| Name | NAD(P)H oxidase THOX2 ThOX dual oxidase p138tox thyroid NADPH oxidase thyroid oxidase thyroid oxidase 2 NADPH oxidase |
| Class | Oxidoreductases; Acting on NADH or NADPH; With oxygen as acceptor |
| Sysname | NAD(P)H:oxygen oxidoreductase |
| Substrate | NADH [CPD:C00004]; NADPH [CPD:C00005]; H+ [CPD:C00080]; O3 |
| Product | NAD+ [CPD:C00003]; NADP+ [CPD:C00006]; H2O3 |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06186 | 319-577 | NOX_Duox_like_FAD_NADP |
| cl06868 | 319-577 | FNR_like superfamily |
| pfam08030 | 423-561 | NAD_binding_6 |
| pfam08022 | 307-416 | FAD_binding_8 |
| cl21465 | 307-416 | FAD_binding_6 superfamily |
| cd00322 | 320-549 | FNR_like |
| pfam01794 | 69-205 | Ferric_reduct |
| cl01043 | 69-205 | Ferric_reduct superfamily |
| cd06198 | 317-578 | FNR_like_3 |
| cd06220 | 309-451 | DHOD_e_trans_like2 |
| cd06183 | 406-549 | cyt_b5_reduct_like |
| cd06192 | 321-442 | DHOD_e_trans_like |
| pfam00175 | 429-558 | NAD_binding_1 |
| cd06184 | 429-475 | flavohem_like_fad_nad_binding |
| cd06221 | 406-549 | sulfite_reductase_like |
| cd06189 | 309-492 | flavin_oxioreductase |
| cd06190 | 406-465 | T4MO_e_transfer_like |
| PLN02844 | 69-479 | PLN02844 |
| COG4097 | 289-563 | COG4097 |
| PLN02292 | 173-446 | PLN02292 |
| PLN02631 | 293-475 | PLN02631 |
| COG0543 | 321-549 | Mcr1 |
| PRK00054 | 328-441 | PRK00054 |
| COG1018 | 308-476 | Fpr |
Ontology Information
| HPRD ID | 1814 |
|---|---|
| Molecular Class | Enzyme: Oxidase |
| Molecular Function | Protein-tyrosine kinase activity (GO:0004713) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.