Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PAWR | 5074 | PRKC, apoptosis, WT1, regulator | 12 | PAR4; Par-4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17848589 | 2007 | Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncologicas (CNIO). Sample Type : CRC tumor and normal tissue No. of Sample : 15 Stage : Duke stage A-C | Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry | Up-regulation | 1.498 |
|
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008] |
| Chromosome | 12 |
| Location | 12q21 |
| Start | 79587791 |
| End | 79691010 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 103220 |
| OMIM ID | 601936 |
| HGNC ID | HGNC:8614 |
| Unigene ID | Hs.643130 |
| Ensembl ID | ENSG00000177425 |
| PharmGKB ID | PA32954 |
mRNA Information
| mRNA ID | XM_006719435.2 |
|---|---|
| Exon | join(202..316,620..1282,69804..69935,77402..77436, 94353..94500,96578..96682,98318..103220) | mRNA Sequence | Download Select all |
| Length | 1967 |
CDS Information
| Location | join(767..1282,69804..69935,77402..77436,94353..94500, 96578..96682,98318..98404) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS31863.1 |
Protein Information
| Protein ID | NP_002574.2 |
|---|---|
| Protein Name | PRKC, apoptosis, WT1, regulator |
| Molecular Wt. (Da) | 36436 |
| Protein Sequence | Download Select all |
| Length | 340 |
| Uniprot ID | Q99439 |
| Ensembl Protein ID | ENSP00000263097 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 8 |
| S | Phosphorylation | 231 |
| S | Phosphorylation | 233 |
| S | Phosphorylation | 228 |
| T | Phosphorylation | 229 |
| Y | Phosphorylation | 226 |
| S | Phosphorylation | 259 |
| T | Phosphorylation | 261 |
| T | Phosphorylation | 230 |
| S | Phosphorylation | 223 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1613 | DAPK3 | 4478 | NP_001339.1 | in vitro;in vivo | 1 291 733 910 602 480 |
| 3309 | HSPA5 | 682 | NP_005338.1 | in vitro;in vivo | 19632185 |
| 5371 | PML | 23 | NP_150241.2 | in vitro;in vivo | 12717420 |
| 5590 | PRKCZ | 1504 | NP_002735.3 | in vitro;in vivo | 8797824 |
| 7490 | WT1 | 6163 | NP_077744.3 | in vitro;in vivo;yeast 2-hybrid | 8943350 |
| 22800 | RRAS2 | 2518 | NP_036382.2 | yeast 2-hybrid | 16169070 |
| 29844 | TFPT | 10266 | NP_037474.1 | in vitro;in vivo;yeast 2-hybrid | 16229834 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| COG0598 | 268-339 | CorA |
| cl00459 | 268-339 | MIT_CorA-like superfamily |
| pfam05911 | 268-331 | DUF869 |
| pfam08614 | 265-332 | ATG16 |
| COG1196 | 266-327 | Smc |
| pfam01544 | 266-338 | CorA |
| PRK12704 | 269-338 | PRK12704 |
| TIGR02168 | 255-333 | SMC_prok_B |
| TIGR04211 | 266-329 | SH3_and_anchor |
Ontology Information
| HPRD ID | 362 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.