Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23135283 | 2012 | Cell line : HCT116, RKO, HeLa, HepG2,HEK 293T ,SV40-COS7 Source : - Sample Type : - No. of Sample : - Stage : - | Western Blotting, Immunoprecipitation,Transfection ,Luciferase Assaysh RNA,Real-time PCR,EMSA,Chromatin Immunoprecipitation,Cell Proliferation, Cell Cycle, and Cell Apoptosis assay | Up-regulation | - | PAX2 promotes proliferation of colon cancer cells through AP-1. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Paired boxes, "Homeoboxes / PRD class" |
| Description | PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| Chromosome | 10 |
| Location | 10q24.31 |
| Start | 102495316 |
| End | 102589698 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 94383 |
| OMIM ID | 167409 |
| HGNC ID | HGNC:8616 |
| Unigene ID | Hs.155644 |
| Ensembl ID | ENSG00000075891 |
| PharmGKB ID | PA32956 |
mRNA Information
| mRNA ID | NM_001304569.1 |
|---|---|
| Exon | join(1..25,10485..10595,14038..14206,14986..15183, 43790..43875,45538..45657,70722..70897,73402..73528, 88940..89041,91301..91387,91835..94233) | mRNA Sequence | Download Select all |
| Length | 3600 |
Protein Information
| Protein ID | NP_001291498.1 |
|---|---|
| Protein Name | paired box 2 |
| Molecular Wt. (Da) | 46585 |
| Protein Sequence | Download Select all |
| Length | 425 |
| Uniprot ID | P23025 |
| Ensembl Protein ID | ENSP00000364270 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3398 | ID2 | 2664 | NP_002157.2 | in vitro | 11134340 |
| 9479 | MAPK8IP1 | 5223 | NP_005447.1 | in vivo | 11700324 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00131 | 16-142 | PAX |
| cl21459 | 16-142 | HTH superfamily |
| smart00351 | 16-140 | PAX |
| pfam00292 | 16-140 | PAX |
| pfam12403 | 304-416 | Pax2_C |
| cl13792 | 304-416 | Pax2_C superfamily |
| pfam13384 | 38-76 | HTH_23 |
| cd00090 | 30-79 | HTH_ARSR |
| pfam00046 | 255-278 | Homeobox |
| cl00084 | 255-278 | homeodomain superfamily |
| pfam13551 | 38-140 | HTH_29 |
| COG3415 | 30-121 | COG3415 |
Ontology Information
| HPRD ID | 1909 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | DNA repair (GO:0006281) |
Drug Information
No matching records could be found.