Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ASAP1 50807 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1  8PAP, KIAA1249, ZG14P, CENTB4 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20154719   2010Cell line : AT1, AT2.1, AT3.1, AT6.1, MatLu, MatLyLu, G, ASML, 10AS, 1AS, SW1116, LS174T.

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Microarray chips,immunoprecipitation,Northern blotting.Up-regulation-ASAP1 can contribute to the dissemination of a variety of tumor types and represent a potential target for cancer therapy.ASAP1 expression is strongly upregulated in a variety of tumors in comparison with normal tissue


Gene Details



NC_000008.10 (131064350..131455906, complement)

View Larger Image
   
Gene Type protein coding
Gene Family ADP-ribosylation factor GTPase activating proteins, "Pleckstrin homology (PH) domain containing", "Ankyrin repeat domain containing"
Description This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]  
Chromosome 8
Location 8q24.1-q24
Start 131064350  
End 131455906  
Strand -  
Gene Sequence

   Download   Select all

Length 391557  
OMIM ID 605953   
HGNC ID HGNC:2720   
Unigene ID Hs.655552   
Ensembl ID ENSG00000153317   
PharmGKB ID PA164716055   

mRNA Information


mRNA ID ?NM_001247996.1
Exon  
mRNA Sequence

   Download   Select all

Length  



CDS Information


   
Location
CDS Sequence

   Download   Select all

CCDS ID CCDS6362.1



Protein Information


      
Protein IDNP_001234925.1
Protein NameArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 1129  
Uniprot IDQ9GZV4
Ensembl Protein ID ENSP00000295822  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation501;-
SPhosphorylation502;-
SPhosphorylation839
SPhosphorylation843
SPhosphorylation1027
TPhosphorylation915
SPhosphorylation924
SPhosphorylation925
SPhosphorylation1008
SPhosphorylation129
TPhosphorylation837
SPhosphorylation717

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2185PTK2B3131NP_004094.3in vitro;in vivo;yeast 2-hybrid12771146   
3055HCK796NP_002101.2in vivo12029088   
5747PTK22859NP_005598.3in vitro;in vivo;yeast 2-hybrid12058076   
5829PXN3937BAA18998.1in vitro12149250   
6714SRC1819NP_005408.1in vitro;in vivo9819391   
9185REPS22262Q8NFH8in vitro;in vivo;yeast 2-hybrid12149250   
29763PACSIN35937NP_057307.2yeast 2-hybrid15719014   
30011SH3KBP12301NP_114098.1in vitro;in vivo;yeast 2-hybrid1   571   901   417   255   940   


Pathway Information


            
Pathway Name Pathway ID
Endocytosis hsa04144
Fc gamma R-mediated phagocytosis hsa04666


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0764154-268  BAR_ASAP1
cl1201354-268  BAR superfamily
cd13251316-422  PH_ASAP
cl17171316-422  PH-like superfamily
cd119651071-1127  SH3_ASAP1
cl170361071-1127  SH3 superfamily
cd00204601-689  ANK
cl02529601-689  ANK superfamily
cd0760454-268  BAR_ASAPs
cd0764254-268  BAR_ASAP2
cd0764054-268  BAR_ASAP3
pfam01412439-555  ArfGap
cl02464439-555  ArfGap superfamily
smart00105445-552  ArfGap
cd118211071-1123  SH3_ASAP
cd0730764-264  BAR
cd119661071-1125  SH3_ASAP2
cd13250327-420  PH_ACAP
cd00204601-677  ANK
smart003261068-1124  SH3
cd001741071-1123  SH3
smart00233327-411  PH
cd0760350-265  BAR_ACAPs
cd118401071-1124  SH3_Intersectin_5
cd00821327-411  PH
pfam00169326-411  PH
cd118751071-1126  SH3_CD2AP-like_3
cd0763954-264  BAR_ACAP1
cd118201070-1124  SH3_STAM
cd119631070-1124  SH3_STAM2
cd119641070-1124  SH3_STAM1
pfam146041075-1125  SH3_9
cd119611072-1124  SH3_Abp1_fungi_C2
cd07601107-254  BAR_APPL
cd00204599-657  ANK
cd118031073-1127  SH3_Endophilin_A
cd0763757-265  BAR_ACAP3
cd118261071-1124  SH3_Abi
cd118871071-1124  SH3_Bbc1
cd117621072-1120  SH3_FCHSD_2
cd118771072-1126  SH3_PIX
cd118191071-1126  SH3_Cortactin_like
cd0763290-260  BAR_APPL2
cd07631107-272  BAR_APPL1
cd118231071-1124  SH3_Nostrin
cd119951071-1126  SH3_Intersectin1_5
cd120571073-1127  SH3_CIN85_3
cd117961071-1124  SH3_DNMBP_N3
cd117901071-1123  SH3_Amphiphysin
cd119501072-1124  SH3_GRAP2_C
cd13298327-413  PH1_PH_fungal
cd0763571-264  BAR_GRAF2
cd13280326-419  PH_SIP3
pfam000181073-1121  SH3_1
cd117821076-1126  SH3_Sorbs_2
cd118271071-1124  SH3_MyoIe_If_like
cd120521076-1124  SH3_CIN85_1
cd118741071-1126  SH3_CD2AP-like_2
cd119961071-1126  SH3_Intersectin2_5
cd118051071-1124  SH3_GRB2_like_C
cd0763462-264  BAR_GAP10-like
cd13282327-413  PH1_PLEKHH1_PLEKHH2
cd0763854-265  BAR_ACAP2
cd13296327-414  PH2_MyoX
cd0763354-246  BAR_OPHN1
cd118251072-1124  SH3_PLCgamma
cd118161071-1124  SH3_Eve1_3
cd119921075-1124  SH3_Intersectin2_3
cd118731072-1124  SH3_CD2AP-like_1
cd118821071-1124  SH3_GRAF-like
cd117721072-1124  SH3_OSTF1
pfam076531071-1124  SH3_2
cd120611072-1124  SH3_betaPIX
cd118171075-1123  SH3_Eve1_4
cd118381076-1124  SH3_Intersectin_3
cd117631071-1126  SH3_SNX9_like
cd120561073-1126  SH3_CD2AP_3
cd119601071-1124  SH3_Abp1_eu
cd119231076-1127  SH3_Sorbs2_2
cd121421073-1124  SH3_D21-like
cd118431071-1124  SH3_PACSIN
cd13253326-417  PH1_ARAP
cd118121071-1124  SH3_AHI-1
cd00204631-677  ANK
cd120731075-1127  SH3_HS1
cd119971071-1124  SH3_PACSIN3
cd117781072-1123  SH3_Bzz1_2
cd120461072-1124  SH3_p67phox_C
cd118371071-1124  SH3_Intersectin_2
cd120601072-1124  SH3_alphaPIX
cd120541070-1124  SH3_CD2AP_2
cd118761075-1124  SH3_MLK
cd119511072-1125  SH3_GRAP_C
cd118181071-1123  SH3_Eve1_5
cd01233327-416  PH_KIFIA_KIFIB
cd118971071-1126  SH3_SNX18
cd119201073-1124  SH3_Sorbs2_1
cd117811073-1126  SH3_Sorbs_1
cd119621071-1126  SH3_Abp1_fungi_C1
cd117751070-1126  SH3_Sla1p_3
cd119711071-1124  SH3_Abi1
cd118281075-1126  SH3_ARHGEF9_like
cd118131071-1126  SH3_SGSM3
cd118331075-1125  SH3_Stac_1
cd118791074-1126  SH3_Bem1p_2
cd118941072-1124  SH3_FCHSD2_2
cd120581075-1124  SH3_MLK4
cd0760660-264  BAR_SFC_plant
cd118721075-1126  SH3_DOCK_AB
cd119591075-1126  SH3_Cortactin
cd13255327-417  PH_TAAP2-like
cd120551071-1124  SH3_CIN85_2
cd119291071-1126  SH3_SH3RF2_1
cd118361071-1124  SH3_Intersectin_1
cd119721069-1128  SH3_Abi2
cd120471071-1124  SH3_Noxa1_C
cd13266327-408  PH_Skap_family
cd119341070-1124  SH3_Lasp1_C
cd119981071-1124  SH3_PACSIN1-2
cd117581071-1124  SH3_CRK_N
cd119221076-1128  SH3_Sorbs1_2
cd117861073-1126  SH3_SH3RF_1
cd118701071-1124  SH3_p67phox-like_C
cd119741073-1126  SH3_ASEF2
cd119911074-1124  SH3_Intersectin1_3
cd13308322-418  PH_3BP2
cd13215321-411  PH-GRAM1_AGT26
cd119491072-1124  SH3_GRB2_C
cd119891071-1126  SH3_Intersectin1_2
cd119481075-1126  SH3_GRAP_N
cd118411072-1124  SH3_SH3YL1_like
cd119701072-1124  SH3_PLCgamma1
cd119901080-1126  SH3_Intersectin2_2
cd118061075-1125  SH3_PRMT2
cd118071071-1105  SH3_ASPP
cd13288326-421  PH_Ses
cd117701071-1124  SH3_Nephrocystin
cd118421071-1126  SH3_Ysc84p_like
cd118891071-1124  SH3_Cyk3p-like
cd118961071-1126  SH3_SNX33
smart0072142-265  BAR
cd10573327-411  PH_DAPP1
cd117891071-1124  SH3_Nebulin_family_C
cd118661075-1111  SH3_SKAP1-like
cd119461076-1126  SH3_GRB2_N
cd13276327-409  PH_AtPH1
cd119331070-1124  SH3_Nebulin_C
cd119861075-1124  SH3_Stac3_1
cd119241076-1126  SH3_Vinexin_2
cd119191070-1127  SH3_Sorbs1_1
cd120451075-1111  SH3_SKAP2
pfam0311490-267  BAR
cd120591075-1124  SH3_MLK1-3
cd117791070-1124  SH3_Irsp53_BAIAP2L
cd119731073-1126  SH3_ASEF
cd117801071-1124  SH3_Sorbs_3
cd119991071-1124  SH3_PACSIN_like
cd118301076-1124  SH3_VAV_2
cd118241075-1124  SH3_PSTPIP1
cd117661076-1124  SH3_Nck_2
cd119531072-1105  SH3_ASPP2
cd13289329-411  PH_Osh3p_yeast
cd119211070-1127  SH3_Vinexin_1
cd119751067-1126  SH3_ARHGEF9
cd118561074-1111  SH3_p47phox_like
cd120441073-1111  SH3_SKAP1
cd119271073-1126  SH3_SH3RF1_1
cd119691072-1124  SH3_PLCgamma2
cd117671071-1105  SH3_Nck_3
cd13273327-409  PH_SWAP-70
cd118041076-1124  SH3_GRB2_like_N
pfam0932564-243  Vps5
cd120531076-1124  SH3_CD2AP_1
cd13292328-418  PH_Osh1p_Osh2p_yeast
cd118691071-1127  SH3_p40phox
cd117731072-1105  SH3_Sla1p_1
pfam00023637-667  Ank
cd120511074-1126  SH3_DOCK1_5_A
cd120011073-1127  SH3_BCAR1
cd13284327-422  PH_OSBP_ORP4
pfam13637603-657  Ank_4
COG5347432-552  COG5347
PLN03114451-513  PLN03114
PLN03131430-553  PLN03131
pfam12796587-667  Ank_2
PLN03119430-553  PLN03119
COG0666601-711  ANKYR
pfam12796605-677  Ank_2
PHA03247724-1060  PHA03247
PHA03095580-676  PHA03095
PHA03095599-676  PHA03095
pfam13637637-677  Ank_4
pfam13857619-677  Ank_5
pfam15240953-1015  Pro-rich
PHA03247758-1059  PHA03247
TIGR00870578-700  trp
COG0610161-308  COG0610


Ontology Information


   
HPRD ID10101
Molecular ClassGTPase activating protein
Molecular FunctionProtein binding (GO:0005515)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO