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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FOXP3 | 50943 | forkhead box P3 | X | JM2, XPID, AIID, PIDX, DIETER, SCURFIN |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24291052 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : 13 anonymous CRC patients and from 10 male rats Stage : - | Real time RT-PCR, promoter demethylations assays | Demethylation | - | FoxP3 seems to be an interesting biomarker for immune response to epithelial tumors. A significant 3.5-fold increase of the demethylation in FoxP3 promoter region was found in human CRC and rat ICC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Forkhead boxes |
| Description | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Chromosome | X |
| Location | Xp11.23 |
| Start | 49250436 |
| End | 49269727 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 19292 |
| OMIM ID | 300292 |
| HGNC ID | HGNC:6106 |
| Unigene ID | Hs.247700 |
| Ensembl ID | ENSG00000049768 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_014008.4 |
|---|---|
| Exon | complement(<19202..>19292) | mRNA Sequence | Download Select all |
| Length | 2292 |
CDS Information
| Location | join(4766..5067,11201..11432,12163..12301,12716..12803, 12873..12977,13926..14013,14219..14299,15661..15811, 16526..16602,17963..18064,18245..18394) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | XP_006724596.2 |
|---|---|
| Protein Name | forkhead box P3 |
| Molecular Wt. (Da) | 49567 |
| Protein Sequence | Download Select all |
| Length | 454 |
| Uniprot ID | Q16787 |
| Ensembl Protein ID | ENSP00000324532 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 861 | RUNX1 | 1043 | NP_001745.2 | in vitro;in vivo | 17377532 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Inflammatory bowel disease (IBD) | hsa05321 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00059 | 337-409 | FH |
| cl00061 | 337-409 | FH superfamily |
| smart00339 | 337-409 | FH |
| pfam00250 | 337-410 | Fork_head |
| COG5025 | 335-429 | COG5025 |
| COG5025 | 324-416 | COG5025 |
Ontology Information
| HPRD ID | 2532 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.