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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PCCB | 5096 | propionyl CoA carboxylase, beta polypeptide | 3 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9311592 | 1997 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 10 Stage : - | in situ hybridization ,Confocal microscopy and quantitative analysis | Down-regulation | - | In all cases, the levels of mRNA were lower in colorectal cancers than in normal mucosae. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] |
| Chromosome | 3 |
| Location | 3q21-q22 |
| Start | 135969167 |
| End | 136056737 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 87571 |
| OMIM ID | 232050 |
| HGNC ID | HGNC:8654 |
| Unigene ID | Hs.63788 |
| Ensembl ID | ENSG00000114054 |
| PharmGKB ID | PA32993 |
mRNA Information
| mRNA ID | NM_001178014.1 |
|---|---|
| Exon | join(1..234,5532..5651,6231..6299,8852..8911,10155..10211, 11628..11741,33513..33623,43432..43540,47628..47748, 50706..50787,66617..66740,76479..76586,76831..76931, 77310..77408,78434..78533,79581..79847) | mRNA Sequence | Download Select all |
| Length | 1885 |
Protein Information
| Protein ID | NP_001171485.1 |
|---|---|
| Protein Name | propionyl CoA carboxylase, beta polypeptide |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 559 |
| Uniprot ID | O43542 |
| Ensembl Protein ID | ENSP00000343392 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5095 | PCCA | 1981 | NP_000273.2 | yeast 2-hybrid | 11749052 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Carbon metabolism | hsa01200 |
| Glyoxylate and dicarboxylate metabolism | hsa00630 |
| Metabolic pathways | hsa01100 |
| Propanoate metabolism | hsa00640 |
| Valine, leucine and isoleucine degradation | hsa00280 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| COG0777 | 63-210 | AccD |
| cl21466 | 63-210 | crotonase-like superfamily |
| PRK05654 | 63-173 | PRK05654 |
| TIGR03133 | 64-268 | malonate_beta |
| TIGR00515 | 63-239 | accD |
| PRK07189 | 64-267 | PRK07189 |
| TIGR00513 | 317-507 | accA |
| cl21466 | 317-507 | crotonase-like superfamily |
| COG0825 | 340-484 | AccA |
| CHL00174 | 63-179 | accD |
| PRK05724 | 340-438 | PRK05724 |
| TIGR03134 | 340-481 | malonate_gamma |
| COG4799 | 37-539 | MmdA |
| pfam01039 | 57-533 | Carboxyl_trans |
| TIGR01117 | 37-539 | mmdA |
| PLN02820 | 13-512 | PLN02820 |
| PLN03230 | 340-506 | PLN03230 |
Ontology Information
| HPRD ID | 2482 |
|---|---|
| Molecular Class | Enzyme: Carboxylase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P05166 | DB00161 | L-Valine | SmallMoleculeDrug |
| P05166 | DB00121 | Biotin | SmallMoleculeDrug |
| P05166 | DB00161 | L-Valine | SmallMoleculeDrug |