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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ANGPTL4 | 51129 | angiopoietin-like 4 | 19 | pp1158, PGAR, ARP4, HFARP, FIAF, NL2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26417691 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 44 Stage : - | Immunohistochemistry, RT-PCR,Western blotting | Up-regulation | - | ANGPTL4 is one of the factors involved in the progression of human colorectal cancer, especially venous invasion and distant metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fibrinogen C domain containing |
| Description | This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013] |
| Chromosome | 19 |
| Location | 19p13.3 |
| Start | 8429011 |
| End | 8439257 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 10247 |
| OMIM ID | 605910 |
| HGNC ID | HGNC:16039 |
| Unigene ID | Hs.9613 |
| Ensembl ID | - |
| PharmGKB ID | PA24797 |
Protein Information
| Protein ID | NP_001034756.1 |
|---|---|
| Protein Name | angiopoietin-like 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 406 |
| Uniprot ID | Q9HD89 |
| Ensembl Protein ID | ENSP00000221515 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| PPAR signaling pathway | hsa03320 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00087 | 183-400 | FReD |
| cl00085 | 183-400 | FReD superfamily |
| smart00186 | 184-400 | FBG |
| pfam00147 | 185-399 | Fibrinogen_C |
| pfam10186 | 93-203 | Atg14 |
Ontology Information
| HPRD ID | 13761 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.