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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NIN 51199 ninein (GSK3B interacting protein)  14- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22207051   2012Cell line : -

Source : -

Sample Type : Population based case control study

No. of Sample : 7052 Cases

Stage : -

Univariate and multivariate analysesUp-regulation-Increasing NIN and LNR were significantly associated with worse recurrence-free survival and overall survival.


Gene Details



NC_000014.8 (51186481..51297839, complement)

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Gene Type protein coding
Gene Family EF-hand domain containing
Description This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]  
Chromosome 14
Location 14q21-q22
Start 51186481  
End 51297839  
Strand -  
Gene Sequence

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Length 111359  
OMIM ID 608684   
HGNC ID HGNC:14906   
Unigene ID Hs.310429   
Ensembl ID ENSG00000100503   
PharmGKB ID PA31630   

mRNA Information


mRNA ID ?NM_016350.4
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS32078.2



Protein Information


      
Protein IDNP_057434.4
Protein Nameninein (GSK3B interacting protein)
Molecular Wt. (Da)0
Protein Sequence

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Length 2090  
Uniprot IDQ9NQU5
Ensembl Protein ID ENSP00000260404  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1550;-
SPhosphorylation1556;-
SPhosphorylation1550;-
SPhosphorylation1533;-
SPhosphorylation1550;-
TPhosphorylation2019

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
636BICD13730NP_001705.2in vivo17139249   
2932GSK3B5418NP_002084.2yeast 2-hybrid11004522   
5566PRKACA3382NP_002721.1in vitro12927815   
6790AURKA4066NP_003591.2in vitro12927815   
7329UBE2I9045NP_003336.1in vitro;in vivo;yeast 2-hybrid16154161   
7341SUMO13554NP_003343.1in vitro;in vivo;yeast 2-hybrid16154161   
8554PIAS116029NP_057250.1in vitro16154161   
10006ABI14336NP_005461.2in vitro15048123   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
PRK01194411-504  PRK01194
cl20015411-504  PRK01194 superfamily
pfam03961475-567  DUF342
cl19219475-567  DUF342 superfamily
TIGR02168407-825  SMC_prok_B
COG1196920-1648  Smc
TIGR02168358-1022  SMC_prok_B
TIGR02168404-1098  SMC_prok_B
COG1196648-1403  Smc
COG0419389-1055  SbcC
COG11961164-1960  Smc
TIGR02168412-1240  SMC_prok_B
COG11961452-1786  Smc
COG11961001-1785  Smc
COG1196486-1339  Smc
TIGR02168354-1100  SMC_prok_B
COG0419316-855  SbcC
TIGR045231446-1817  Mplasa_alph_rch
COG1196425-1099  Smc
PTZ00121401-986  PTZ00121
TIGR02169359-955  SMC_prok_A
TIGR02168696-1637  SMC_prok_B
COG1196412-798  Smc
TIGR02168615-1337  SMC_prok_B
COG1196359-617  Smc
TIGR021681001-1812  SMC_prok_B
COG11961274-1964  Smc
pfam02463655-1522  SMC_N
TIGR021691543-1810  SMC_prok_A
TIGR021681432-2063  SMC_prok_B
COG0419699-1267  SbcC
PTZ00121374-971  PTZ00121
TIGR02169360-1310  SMC_prok_A
COG1196373-1100  Smc
PRK03918418-954  PRK03918
PRK02224361-805  PRK02224
TIGR045231508-1957  Mplasa_alph_rch
PTZ00121382-898  PTZ00121
TIGR021691449-1654  SMC_prok_A
TIGR02168899-1644  SMC_prok_B
TIGR021691486-1806  SMC_prok_A
COG04191349-1966  SbcC
pfam12128489-1102  DUF3584
PRK05771368-562  PRK05771
pfam04111384-516  APG6
TIGR02169741-1596  SMC_prok_A
pfam04111829-973  APG6
pfam02463315-983  SMC_N
TIGR021681537-1882  SMC_prok_B
TIGR021681222-1959  SMC_prok_B
PTZ00121389-982  PTZ00121
TIGR00606853-1802  rad50
COG3264707-948  MscK
pfam12128359-878  DUF3584
COG50591508-1729  KIP1
COG3096661-1017  MukB
PRK039181147-1731  PRK03918
PRK039181270-1810  PRK03918
TIGR02168336-560  SMC_prok_B
TIGR021691446-1645  SMC_prok_A
pfam07888651-982  CALCOCO1
pfam13514432-1398  AAA_27
PRK03918362-882  PRK03918
TIGR02169345-564  SMC_prok_A
pfam05557547-1037  MAD
pfam131661631-1812  AAA_13
COG1269368-562  NtpI
TIGR021691605-1876  SMC_prok_A
COG5271477-974  MDN1
TIGR031851517-1810  DNA_S_dndD
PRK12704666-798  PRK12704
pfam078881525-1811  CALCOCO1
PRK12704428-561  PRK12704
TIGR021691579-1928  SMC_prok_A
TIGR00618477-1207  sbcc
PRK03918752-1315  PRK03918
PRK11281655-983  PRK11281
pfam02463824-1701  SMC_N
TIGR04523381-924  Mplasa_alph_rch
TIGR03185320-579  DNA_S_dndD
PTZ001211455-1646  PTZ00121
COG15111503-1812  YhgE
TIGR042111504-1604  SH3_and_anchor
TIGR042111556-1660  SH3_and_anchor
COG50221556-1802  COG5022
PTZ001211457-1966  PTZ00121
TIGR00606435-1024  rad50
pfam02463425-1343  SMC_N
pfam05262629-802  Borrelia_P83
TIGR021681736-1968  SMC_prok_B
TIGR02169349-560  SMC_prok_A
TIGR00606608-1317  rad50
PRK12704767-897  PRK12704
pfam05262304-515  Borrelia_P83
pfam13166354-682  AAA_13
COG11961713-2066  Smc
pfam097261751-1954  Macoilin
PRK05771368-506  PRK05771
TIGR02680616-853  TIGR02680
TIGR01814305-425  kynureninase
PLN032291556-1810  PLN03229
PRK01156373-838  PRK01156
TIGR04523418-1024  Mplasa_alph_rch
pfam01496666-882  V_ATPase_I
pfam05622697-1099  HOOK
PRK03918780-1342  PRK03918
pfam059111559-1817  DUF869
COG3206728-887  GumC
PRK127041506-1646  PRK12704
TIGR03319636-803  RNase_Y
COG2433390-524  COG2433
COG2433796-991  COG2433
COG5281628-1035  COG5281
TIGR030071167-1339  pepcterm_ChnLen
PRK112811553-1783  PRK11281
pfam097261628-1813  Macoilin
pfam05911384-496  DUF869
TIGR00414420-515  serS
pfam04111393-555  APG6
TIGR042111552-1646  SH3_and_anchor
pfam041111504-1623  APG6
PTZ00121648-1043  PTZ00121


Ontology Information


   
HPRD ID13255
Molecular ClassUnclassified
Molecular FunctionProtein tyrosine/serine/threonine phosphatase activity (GO:0008138)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO