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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DACT1 | 51339 | dishevelled-binding antagonist of beta-catenin 1 | 14 | DAPPER1, THYEX3, HDPR1, DAPPER, FRODO |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22470507 | 2012 | Cell line : - Source : Peking University Third Hospital, China. Sample Type : CRC tumor No. of Sample : - Stage : - | real time RT-PCR,Immunoblotting,Soft agar colony assay,Flow cytometry,Immunohistochemistry | Up-regulation | - | �DACT1�as an important positive regulator in colon�cancer�and suggests a potential strategy for the therapeutic control of the ?-catenin-dependent pathway. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] |
| Chromosome | 14 |
| Location | 14q22.3 |
| Start | 59100786 |
| End | 59115039 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14254 |
| OMIM ID | 607861 |
| HGNC ID | HGNC:17748 |
| Unigene ID | Hs.48950 |
| Ensembl ID | ENSG00000165617 |
| PharmGKB ID | PA134957283 |
Protein Information
| Protein ID | NP_001072988.1 |
|---|---|
| Protein Name | dishevelled-binding antagonist of beta-catenin 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 836 |
| Uniprot ID | O60218 |
| Ensembl Protein ID | ENSP00000352584 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam15268 | 46-836 | Dapper |
| COG1196 | 22-149 | Smc |
| PHA03378 | 406-566 | PHA03378 |
Ontology Information
| HPRD ID | 7259 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Protein binding (GO:0005515) |
| Biological Process | Regulation of cell growth (GO:0001558) |
Drug Information
No matching records could be found.