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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PDGFB | 5155 | platelet-derived growth factor beta polypeptide | 22 | SSV |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24331325 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Angiogenesis Fast Quant technology | Down-regulation | - | PDGF-bb protein expression might be an independent prognostic marker or in association with other parameters for CRC patients. downregulation of PDGF-bb protein expression in the serum of patients with colorectal cancer compared with the control group. Thus, PDGF-bb might play an essential function in the progression of CRC. Sample size: 28 CRC and 10 control. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. |
| Chromosome | 22 |
| Location | 22q13.1 |
| Start | 39223680 |
| End | 39244952 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 21273 |
| OMIM ID | 190040 |
| HGNC ID | HGNC:8800 |
| Unigene ID | Hs.1976 |
| Ensembl ID | ENSG00000100311 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002608.2 |
|---|---|
| Exon | join(1..1052,9079..9175,11429..11518,13126..13331, 14725..14869,19106..19258,19640..21273) | mRNA Sequence | Download Select all |
| Length | 3393 |
CDS Information
| Location | join(4044..4098,9079..9175,11429..11518,13126..13331, 14725..14869,19106..19258,19640..21273) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS13987.1 |
Protein Information
| Protein ID | NP_002599.1 |
|---|---|
| Protein Name | platelet-derived growth factor beta polypeptide |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | P55795 |
| Ensembl Protein ID | ENSP00000361927 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2 | A2M | 72 | NP_000005.2 | in vitro;in vivo | 10681572 |
| 1277 | COL1A1 | 362 | NP_000079.2 | in vitro | 10446987 |
| 3183 | HNRNPC | 1243 | P07910 | in vitro | 10409733 |
| 3265 | HRAS | 1813 | NP_005334.1 | in vitro | 10485711 |
| 3339 | HSPG2 | 804 | NP_005520.4 | in vitro | 9692901 |
| 4035 | LRP1 | 138 | NP_002323.2 | in vivo | 11854294 |
| 5156 | PDGFRA | 1429 | NP_006197.1 | in vitro;in vivo | 2544881 |
| 5159 | PDGFRB | 1423 | NP_002600.1 | in vitro;in vivo | 11903042 |
| 7057 | THBS1 | 1765 | NP_003237.2 | in vivo | 9334164 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Choline metabolism in cancer | hsa05231 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Focal adhesion | hsa04510 |
| Gap junction | hsa04540 |
| Glioma | hsa05214 |
| HTLV-I infection | hsa05166 |
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| MicroRNAs in cancer | hsa05206 |
| Pathways in cancer | hsa05200 |
| Phospholipase D signaling pathway | hsa04072 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prostate cancer | hsa05215 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
| Renal cell carcinoma | hsa05211 |
Structure Information
| PDB ID | 1PDG |
|---|---|
| Resolution | 3 |
| Method | ? X-RAY DIFFRACTION |
| Chains | A, B, |
| Molecule | PLATELET-DERIVED GROWTH FACTOR BB |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00135 | 95-182 | PDGF |
| cl00116 | 95-182 | PDGF superfamily |
| pfam00341 | 97-180 | PDGF |
| smart00141 | 95-182 | PDGF |
| pfam04692 | 21-96 | PDGF_N |
| cl04679 | 21-96 | PDGF_N superfamily |
| PHA02661 | 97-193 | PHA02661 |
Ontology Information
| HPRD ID | 772 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.