Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PDGFRB | 5159 | platelet-derived growth factor receptor, beta polypeptide | 5 | JTK12, CD140b, PDGFR1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23146028 | 2012 | Cell line : T84, LOVO, LS174T, HT 29, LS180, SW48, SW480, COLO205 Source : European Collection of Cell Cultures. Sample Type : - No. of Sample : - Stage : TNM Stage I-IV | Genotyping,DNA sequencing, | Polymorhpism | - | PDGFR exon 19 c.2601A>G SNP is commonly encountered in CRC patients and is associated with increased pathway activation and poorer survival. |
| 23441134 | 2013 | Cell line : C26, MC38 Source : - Sample Type : - No. of Sample : - Stage : - | R2 microarray,Flow Cytometry,Western Blotting,Invasion Assay,Immunohistochemistry. | Up-regulation | - | PDGFRB may contribute to the aggressive phenotype of colorectal tumors with mesenchymal properties, most likely downstream of platelet activation and TGFB signaling. |
| 23900414 | 2013 | Cell line : SW480, DLD 1, Caco 2 Source : - Sample Type : - No. of Sample : - Stage : - | Western blotting,real time RT-PCR,Transfection,cell proliferation assay | Up-regulation | - | PDGFR? in CRC cell lines, SW480, DLD-1 and Caco-2 cells showing high PDGFR? expression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / I-set domain containing", "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5q33.1 |
| Start | 149493402 |
| End | 149535447 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 42046 |
| OMIM ID | 173410 |
| HGNC ID | HGNC:8804 |
| Unigene ID | Hs.509067 |
| Ensembl ID | ENSG00000113721 |
| PharmGKB ID | PA33148 |
mRNA Information
| mRNA ID | XM_005268464.2 |
|---|---|
| Exon | join(1..488,20007..20330,20869..21135,21877..22004, 22125..22299,22943..23135,23791..23906,25223..25346, 25917..26128,29271..29365,30308..30440,31054..31158, 31525..31635,32684..32843,33845..34005,34563..34681, 34875..34997,35762..35873,36319..36418,37033..37138, 38035..38267,39939..42046) | mRNA Sequence | Download Select all |
| Length | 5693 |
Protein Information
| Protein ID | XP_005268521.1 |
|---|---|
| Protein Name | platelet-derived growth factor receptor, beta polypeptide |
| Molecular Wt. (Da) | 43551 |
| Protein Sequence | Download Select all |
| Length | 1042 |
| Uniprot ID | P25490 |
| Ensembl Protein ID | ENSP00000262238 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 1009 |
| Y | Phosphorylation | 1021 |
| Y | Phosphorylation | 579 |
| Y | Phosphorylation | 581 |
| Y | Phosphorylation | 716 |
| Y | Phosphorylation | 740 |
| Y | Phosphorylation | 751 |
| Y | Phosphorylation | 763 |
| Y | Phosphorylation | 771 |
| Y | Phosphorylation | 775 |
| Y | Phosphorylation | 857 |
| Y | Dephosphorylation | 740 |
| Y | Dephosphorylation | 751 |
| Y | Dephosphorylation | 771 |
| Y | Dephosphorylation | 1021 |
| Y | Dephosphorylation | 562 |
| Y | Dephosphorylation | 751 |
| Y | Dephosphorylation | 857 |
| Y | Dephosphorylation | 1021 |
| Y | Dephosphorylation | 579 |
| Y | Dephosphorylation | 751 |
| Y | Dephosphorylation | 771 |
| Y | Dephosphorylation | 1009 |
| Y | Phosphorylation | 934 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 369 | ARAF | 2405 | NP_001645.1 | in vitro;in vivo | 15763428 |
| 1398 | CRK | 1267 | NP_058431.2 | in vitro | 10733900 |
| 1956 | EGFR | 579 | NP_005219.2 | in vivo | 9506992 |
| 2534 | FYN | 655 | NP_002028.1 | in vivo | 16 961 799 425 276 |
| 2549 | GAB1 | 5116 | NP_997006.1 | in vitro | 14973141 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro;in vivo | 7935391 |
| 2886 | GRB7 | 3311 | NP_005301.2 | in vitro;in vivo | 8940081 |
| 5287 | PIK3C2B | 4160 | NP_002637.3 | in vitro;in vivo | 10805725 |
| 5290 | PIK3CA | 1382 | NP_006209.2 | in vivo | 8702949 |
| 5295 | PIK3R1 | 1381 | NP_852664.1 | in vivo | 106 975 031 372 092 |
| 5296 | PIK3R2 | 4404 | NP_005018.1 | in vivo | 11172806 |
| 5335 | PLCG1 | 1398 | NP_002651.2 | in vivo | 8443409 |
| 5894 | RAF1 | 1265 | NP_002871.1 | in vitro | 2475255 |
| 5921 | RASA1 | 745 | NP_002881.1 | in vivo | 10697503 |
| 6714 | SRC | 1819 | NP_005408.1 | in vitro | 2173144 |
| 6772 | STAT1 | 2777 | NP_009330.1 | in vitro;in vivo | 94 848 408 549 654 |
| 6776 | STAT5A | 3301 | NP_003143.2 | in vitro | 9484840 |
| 6777 | STAT5B | 5037 | NP_036580.2 | in vitro | 9484840 |
| 7001 | PRDX2 | 2763 | NP_005800.3 | in vivo | 15902258 |
| 7297 | TYK2 | 1490 | NP_003322.3 | in vitro;in vivo | 86 571 519 484 840 |
| 8503 | PIK3R3 | 5831 | NP_003620.3 | in vivo | 11172806 |
| 8651 | SOCS1 | 4669 | NP_003736.1 | yeast 2-hybrid | 10022833 |
| 8831 | SYNGAP1 | 16018 | NP_006763.2 | in vitro;in vivo | 1374684 |
| 83755 | KRTAP4-12 | 13941 | NP_114060.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Calcium signaling pathway | hsa04020 |
| Central carbon metabolism in cancer | hsa05230 |
| Choline metabolism in cancer | hsa05231 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Focal adhesion | hsa04510 |
| Gap junction | hsa04540 |
| Glioma | hsa05214 |
| HTLV-I infection | hsa05166 |
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| MicroRNAs in cancer | hsa05206 |
| Pathways in cancer | hsa05200 |
| Phospholipase D signaling pathway | hsa04072 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prostate cancer | hsa05215 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05107 | 562-953 | PTKc_PDGFR_beta |
| cl21453 | 562-953 | PKc_like superfamily |
| cd05859 | 314-415 | Ig4_PDGFR-alpha |
| cl11960 | 314-415 | Ig superfamily |
| cd05861 | 228-312 | Ig1_PDGFR-alphabeta |
| cl11960 | 228-312 | Ig superfamily |
| cd05105 | 562-951 | PTKc_PDGFR_alpha |
| cd05055 | 562-953 | PTKc_PDGFR |
| cd05106 | 559-953 | PTKc_CSF-1R |
| cd05104 | 562-953 | PTKc_Kit |
| cd05054 | 593-953 | PTKc_VEGFR |
| cd05103 | 593-953 | PTKc_VEGFR2 |
| cd14207 | 593-953 | PTKc_VEGFR1 |
| cd05102 | 593-953 | PTKc_VEGFR3 |
| cd00192 | 604-953 | PTKc |
| cd05053 | 587-953 | PTKc_FGFR |
| cd05099 | 587-953 | PTKc_FGFR4 |
| cd05098 | 586-953 | PTKc_FGFR1 |
| cd05101 | 582-953 | PTKc_FGFR2 |
| cd05100 | 587-953 | PTKc_FGFR3 |
| cd05045 | 599-952 | PTKc_RET |
| cd05034 | 604-951 | PTKc_Src_like |
| cd05039 | 593-953 | PTKc_Csk_like |
| cd05068 | 593-951 | PTKc_Frk_like |
| cd05032 | 593-953 | PTKc_InsR_like |
| cd05044 | 606-953 | PTKc_c-ros |
| cd05049 | 594-942 | PTKc_Trk |
| cd05041 | 604-953 | PTKc_Fes_like |
| cd05047 | 606-953 | PTKc_Tie |
| cd05089 | 606-953 | PTKc_Tie1 |
| cd05036 | 594-952 | PTKc_ALK_LTK |
| cd05051 | 594-953 | PTKc_DDR |
| cd05148 | 593-951 | PTKc_Srm_Brk |
| cd05059 | 599-952 | PTKc_Tec_like |
| cd05072 | 593-951 | PTKc_Lyn |
| cd05050 | 594-952 | PTKc_Musk |
| cd05052 | 593-953 | PTKc_Abl |
| cd05085 | 603-953 | PTKc_Fer |
| cd05048 | 594-953 | PTKc_Ror |
| cd13999 | 606-953 | STKc_MAP3K-like |
| cd05057 | 594-953 | PTKc_EGFR_like |
| cd05092 | 597-948 | PTKc_TrkA |
| cd05061 | 593-951 | PTKc_InsR |
| cd05067 | 593-951 | PTKc_Lck_Blk |
| cd05088 | 606-953 | PTKc_Tie2 |
| cd05060 | 604-953 | PTKc_Syk_like |
| cd05084 | 603-952 | PTKc_Fes |
| cd05058 | 802-953 | PTKc_Met_Ron |
| cd05046 | 595-953 | PTK_CCK4 |
| cd05056 | 593-953 | PTKc_FAK |
| cd05097 | 594-951 | PTKc_DDR_like |
| cd05082 | 593-953 | PTKc_Csk |
| cd05043 | 785-953 | PTK_Ryk |
| cd05038 | 596-952 | PTKc_Jak_rpt2 |
| cd05035 | 600-952 | PTKc_TAM |
| cd05075 | 599-952 | PTKc_Axl |
| cd05083 | 593-951 | PTKc_Chk |
| cd05074 | 595-951 | PTKc_Tyro3 |
| cd05095 | 594-953 | PTKc_DDR2 |
| cd05113 | 595-953 | PTKc_Btk_Bmx |
| cd05096 | 594-953 | PTKc_DDR1 |
| cd05073 | 593-951 | PTKc_Hck |
| cd05112 | 598-952 | PTKc_Itk |
| cd05033 | 595-953 | PTKc_EphR |
| cd05062 | 593-951 | PTKc_IGF-1R |
| cd14204 | 597-953 | PTKc_Mer |
| cd05094 | 595-948 | PTKc_TrkC |
| cd05114 | 599-953 | PTKc_Tec_Rlk |
| cd05093 | 595-948 | PTKc_TrkB |
| cd05040 | 782-953 | PTKc_Ack_like |
| cd14203 | 604-951 | PTKc_Src_Fyn_like |
| cd05069 | 593-951 | PTKc_Yes |
| cd05091 | 606-951 | PTKc_Ror2 |
| cd00180 | 606-896 | PKc |
| cd05071 | 593-951 | PTKc_Src |
| cd05070 | 593-951 | PTKc_Fyn |
| cd05063 | 604-951 | PTKc_EphR_A2 |
| cd05090 | 594-951 | PTKc_Ror1 |
| cd05115 | 802-951 | PTKc_Zap-70 |
| cd05116 | 808-952 | PTKc_Syk |
| cd04975 | 314-415 | Ig4_SCFR_like |
| cd05066 | 604-953 | PTKc_EphR_A |
| cd05108 | 604-953 | PTKc_EGFR |
| cd05065 | 606-953 | PTKc_EphR_B |
| cd05109 | 802-953 | PTKc_HER2 |
| cd05742 | 228-309 | Ig1_VEGFR_like |
| cd05079 | 604-951 | PTKc_Jak1_rpt2 |
| cd05110 | 803-953 | PTKc_HER4 |
| cd06606 | 599-940 | STKc_MAPKKK |
| cd05081 | 783-953 | PTKc_Jak3_rpt2 |
| cd05111 | 803-953 | PTK_HER3 |
| cd14205 | 783-951 | PTKc_Jak2_rpt2 |
| cd14058 | 606-953 | STKc_TAK1 |
| cd05064 | 594-953 | PTKc_EphR_A10 |
| cd14059 | 606-953 | STKc_MAP3K12_13 |
| cd14206 | 606-950 | PTKc_Aatyk3 |
| cd14148 | 803-952 | STKc_MLK2 |
| cd14146 | 803-952 | STKc_MLK4 |
| cd14061 | 803-953 | STKc_MLK |
| cd05122 | 602-940 | PKc_STE |
| cd05087 | 604-949 | PTKc_Aatyk1 |
| cd05080 | 604-951 | PTKc_Tyk2_rpt2 |
| cd05042 | 606-949 | PTKc_Aatyk |
| cd06627 | 602-949 | STKc_Cdc7_like |
| cd14145 | 803-952 | STKc_MLK1 |
| cd14003 | 601-941 | STKc_AMPK-like |
| cd13978 | 606-951 | STKc_RIP |
| cd14062 | 606-953 | STKc_Raf |
| cd14007 | 602-940 | STKc_Aurora |
| cd14060 | 793-953 | STKc_MLTK |
| cd05117 | 601-903 | STKc_CAMK |
| cd14151 | 593-953 | STKc_B-Raf |
| cd14147 | 803-952 | STKc_MLK3 |
| cd14150 | 599-953 | STKc_A-Raf |
| cd14014 | 602-950 | STKc_PknB_like |
| cd06632 | 603-953 | STKc_MEKK1_plant |
| cd08215 | 604-940 | STKc_Nek |
| cd13979 | 598-949 | STKc_Mos |
| cd06628 | 761-953 | STKc_Byr2_like |
| cd14065 | 606-953 | PKc_LIMK_like |
| cd14149 | 593-953 | STKc_C-Raf |
| cd14027 | 806-953 | STKc_RIP1 |
| cd05086 | 606-941 | PTKc_Aatyk2 |
| cd06612 | 808-949 | STKc_MST1_2 |
| cd06609 | 808-909 | STKc_MST3_like |
| cd06623 | 598-949 | PKc_MAPKK_plant_like |
| cd13992 | 806-953 | PK_GC |
| cd14080 | 602-922 | STKc_TSSK-like |
| cd06608 | 596-949 | STKc_myosinIII_N_like |
| cd14063 | 599-953 | PK_KSR |
| cd05118 | 604-898 | STKc_CMGC |
| cd14154 | 606-953 | STKc_LIMK |
| cd14158 | 597-953 | STKc_IRAK4 |
| cd06614 | 606-949 | STKc_PAK |
| cd14009 | 606-903 | STKc_ATG1_ULK_like |
| cd14221 | 804-953 | STKc_LIMK1 |
| cd14121 | 606-904 | STKc_ULK3 |
| cd14066 | 606-915 | STKc_IRAK |
| cd08217 | 824-949 | STKc_Nek2 |
| cd05037 | 774-953 | PTK_Jak_rpt1 |
| cd14000 | 808-953 | STKc_LRRK |
| cd06611 | 807-953 | STKc_SLK_like |
| cd06631 | 747-953 | STKc_YSK4 |
| cd13975 | 810-949 | PKc_Dusty |
| cd13993 | 606-893 | STKc_Pat1_like |
| cd07849 | 806-898 | STKc_ERK1_2_like |
| cd08530 | 809-953 | STKc_CNK2-like |
| cd14064 | 807-953 | PKc_TNNI3K |
| cd07829 | 788-915 | STKc_CDK_like |
| cd06917 | 814-908 | STKc_NAK1_like |
| cd06621 | 810-905 | PKc_Pek1_like |
| cd06638 | 794-953 | STKc_myosinIIIA_N |
| cd05572 | 809-920 | STKc_cGK |
| cd13996 | 606-897 | STKc_EIF2AK |
| cd07838 | 807-899 | STKc_CDK4_6_like |
| cd05123 | 809-940 | STKc_AGC |
| cd14008 | 606-940 | STKc_LKB1_CaMKK |
| cd14155 | 791-896 | PKc_TESK |
| cd13987 | 807-914 | STKc_SBK1 |
| cd05860 | 306-414 | Ig4_SCFR |
| cd06629 | 806-949 | STKc_Bck1_like |
| cd14042 | 631-953 | PK_GC-A_B |
| cd14002 | 807-903 | STKc_STK36 |
| cd07833 | 601-903 | STKc_CDKL |
| cd14202 | 593-904 | STKc_ULK1 |
| cd14156 | 791-913 | PKc_LIMK_like_unk |
| cd07857 | 806-903 | STKc_MPK1 |
| cd14131 | 820-940 | PKc_Mps1 |
| cd07862 | 767-897 | STKc_CDK6 |
| cd14025 | 808-953 | STKc_RIP4_like |
| cd14222 | 804-953 | STKc_LIMK2 |
| cd07858 | 806-903 | STKc_TEY_MAPK |
| cd14137 | 599-903 | STKc_GSK3 |
| cd07863 | 796-897 | STKc_CDK4 |
| cd06610 | 809-908 | STKc_OSR1_SPAK |
| cd06643 | 809-953 | STKc_SLK |
| cd14120 | 606-914 | STKc_ULK1_2-like |
| cd07830 | 788-899 | STKc_MAK_like |
| cd06622 | 807-953 | PKc_PBS2_like |
| cd06613 | 813-895 | STKc_MAP4K3_like |
| cd06644 | 809-953 | STKc_STK10 |
| cd06641 | 809-949 | STKc_MST3 |
| cd06619 | 810-913 | PKc_MKK5 |
| cd06605 | 604-917 | PKc_MAPKK |
| cd05592 | 813-904 | STKc_nPKC_theta_like |
| cd08223 | 809-953 | STKc_Nek4 |
| cd05581 | 598-933 | STKc_PDK1 |
| cd07834 | 806-898 | STKc_MAPK |
| cd14079 | 601-939 | STKc_AMPK_alpha |
| cd14162 | 602-894 | STKc_TSSK4-like |
| cd14069 | 599-914 | STKc_Chk1 |
| cd14099 | 603-932 | STKc_PLK |
| cd13989 | 810-898 | STKc_IKK |
| cd14039 | 781-895 | STKc_IKK_alpha |
| cd07840 | 797-898 | STKc_CDK9_like |
| cd13997 | 604-949 | PKc_Wee1_like |
| cd05580 | 598-910 | STKc_PKA_like |
| cd06620 | 807-916 | PKc_Byr1_like |
| cd06642 | 809-949 | STKc_STK25 |
| cd14047 | 793-897 | STKc_EIF2AK2_PKR |
| cd07854 | 789-898 | STKc_MAPK4_6 |
| cd14052 | 605-896 | PTKc_Wee1_fungi |
| cd05578 | 810-905 | STKc_Yank1 |
| cd14010 | 805-898 | STKc_ULK4 |
| cd13994 | 790-916 | STKc_HAL4_like |
| cd14001 | 807-949 | PKc_TOPK |
| cd06607 | 813-949 | STKc_TAO |
| cd05078 | 807-951 | PTK_Jak2_rpt1 |
| cd07852 | 808-903 | STKc_MAPK15-like |
| cd05619 | 806-904 | STKc_nPKC_theta |
| cd07859 | 806-903 | STKc_TDY_MAPK |
| cd06647 | 809-948 | STKc_PAK_I |
| cd07832 | 805-903 | STKc_CCRK |
| cd13983 | 809-950 | STKc_WNK |
| cd06625 | 806-949 | STKc_MEKK3_like |
| cd14209 | 809-938 | STKc_PKA |
| cd05616 | 804-986 | STKc_cPKC_beta |
| cd14044 | 796-953 | PK_GC-C |
| cd06640 | 809-896 | STKc_MST4 |
| cd06618 | 786-913 | PKc_MKK7 |
| cd07846 | 798-904 | STKc_CDKL2_3 |
| cd05620 | 806-904 | STKc_nPKC_delta |
| cd05570 | 810-904 | STKc_PKC |
| cd14077 | 806-939 | STKc_Kin1_2 |
| cd08528 | 820-899 | STKc_Nek10 |
| cd06634 | 798-949 | STKc_TAO2 |
| cd06654 | 813-948 | STKc_PAK1 |
| cd14084 | 806-927 | STKc_Chk2 |
| cd06655 | 813-948 | STKc_PAK2 |
| cd14186 | 806-952 | STKc_PLK4 |
| cd06617 | 810-953 | PKc_MKK3_6 |
| cd06648 | 809-919 | STKc_PAK_II |
| cd07847 | 808-898 | STKc_CDKL1_4 |
| cd08225 | 788-899 | STKc_Nek5 |
| cd08221 | 791-949 | STKc_Nek9 |
| cd14201 | 806-904 | STKc_ULK2 |
| cd07845 | 809-919 | STKc_CDK10 |
| cd14011 | 808-904 | PK_SCY1_like |
| cd14050 | 813-953 | PKc_Myt1 |
| cd07877 | 808-905 | STKc_p38alpha |
| cd14068 | 809-953 | STKc_LRRK2 |
| cd05579 | 806-898 | STKc_MAST_like |
| cd14081 | 804-933 | STKc_BRSK1_2 |
| cd06656 | 813-948 | STKc_PAK3 |
| cd05077 | 809-951 | PTK_Jak1_rpt1 |
| cd05589 | 813-905 | STKc_PKN |
| cd14116 | 809-951 | STKc_Aurora-A |
| cd05076 | 809-951 | PTK_Tyk2_rpt1 |
| cd06633 | 792-945 | STKc_TAO3 |
| cd14104 | 798-902 | STKc_Titin |
| cd08529 | 602-949 | STKc_FA2-like |
| cd14173 | 810-903 | STKc_Mnk2 |
| cd07848 | 791-896 | STKc_CDKL5 |
| cd07855 | 806-896 | STKc_ERK5 |
| cd06636 | 809-953 | STKc_MAP4K4_6_N |
| cd06616 | 807-906 | PKc_MKK4 |
| cd14098 | 809-935 | STKc_Rad53_Cds1 |
| cd06630 | 803-950 | STKc_MEKK1 |
| cd07856 | 806-903 | STKc_Sty1_Hog1 |
| cd08222 | 809-899 | STKc_Nek11 |
| cd07836 | 800-903 | STKc_Pho85 |
| cd06652 | 806-949 | STKc_MEKK2 |
| cd07853 | 806-896 | STKc_NLK |
| cd05582 | 809-904 | STKc_RSK_N |
| cd07831 | 788-939 | STKc_MOK |
| cd13985 | 604-896 | STKc_GAK_like |
| cd08219 | 788-899 | STKc_Nek3 |
| cd07880 | 808-898 | STKc_p38gamma |
| cd14043 | 801-953 | PK_GC-2D |
| cd07841 | 809-906 | STKc_CDK7 |
| cd07871 | 794-926 | STKc_PCTAIRE3 |
| cd14049 | 808-902 | STKc_EIF2AK1_HRI |
| cd14012 | 805-893 | PK_eIF2AK_GCN2_rpt1 |
| cd06626 | 806-953 | STKc_MEKK4 |
| cd14193 | 763-941 | STKc_MLCK4 |
| cd08229 | 791-949 | STKc_Nek7 |
| cd14082 | 809-916 | STKc_PKD |
| cd14175 | 598-908 | STKc_RSK1_C |
| cd07851 | 808-898 | STKc_p38 |
| cd08228 | 791-910 | STKc_Nek6 |
| cd14076 | 601-922 | STKc_Kin4 |
| cd05585 | 806-913 | STKc_YPK1_like |
| cd05630 | 806-919 | STKc_GRK6 |
| cd05611 | 763-903 | STKc_Rim15_like |
| cd06639 | 794-949 | STKc_myosinIIIB_N |
| cd14178 | 810-908 | STKc_RSK3_C |
| cd14210 | 806-903 | PKc_DYRK |
| cd14176 | 808-908 | STKc_RSK2_C |
| cd07843 | 808-939 | STKc_CDC2L1 |
| cd14164 | 809-906 | STKc_TSSK6-like |
| cd14048 | 809-896 | STKc_EIF2AK3_PERK |
| cd14090 | 810-904 | STKc_Mnk |
| cd14111 | 802-907 | STKc_SPEG_rpt2 |
| cd06659 | 810-904 | STKc_PAK6 |
| cd05612 | 806-903 | STKc_PRKX_like |
| cd07860 | 806-898 | STKc_CDK2_3 |
| cd07864 | 797-898 | STKc_CDK12 |
| cd14165 | 808-938 | STKc_TSSK1_2-like |
| cd14057 | 797-953 | PK_ILK |
| cd14184 | 792-933 | STKc_DCKL2 |
| cd08224 | 788-899 | STKc_Nek6_7 |
| cd06646 | 798-913 | STKc_MAP4K5 |
| cd14108 | 784-904 | STKc_SPEG_rpt1 |
| cd06624 | 791-953 | STKc_ASK |
| cd14177 | 808-908 | STKc_RSK4_C |
| cd07872 | 797-915 | STKc_PCTAIRE2 |
| cd14174 | 810-903 | STKc_Mnk1 |
| cd14208 | 809-951 | PTK_Jak3_rpt1 |
| cd06615 | 807-917 | PKc_MEK |
| cd14103 | 792-891 | STKc_MLCK |
| cd06653 | 806-949 | STKc_MEKK3_like_u1 |
| cd05605 | 809-904 | STKc_GRK4_like |
| cd07861 | 796-898 | STKc_CDK1_euk |
| cd07873 | 806-915 | STKc_PCTAIRE1 |
| cd14136 | 807-898 | STKc_SRPK |
| cd06635 | 798-949 | STKc_TAO1 |
| cd14006 | 793-892 | STKc_MLCK-like |
| cd06637 | 809-953 | STKc_TNIK |
| cd13968 | 786-846 | PKc_like |
| cd07878 | 808-907 | STKc_p38beta |
| cd14191 | 791-935 | STKc_MLCK1 |
| pfam13895 | 222-310 | Ig_2 |
| cd05577 | 795-904 | STKc_GRK |
| cd06650 | 807-905 | PKc_MEK1 |
| cd05587 | 804-903 | STKc_cPKC |
| cd07866 | 791-898 | STKc_BUR1 |
| cd08220 | 791-953 | STKc_Nek8 |
| cd14192 | 791-904 | STKc_MLCK3 |
| cd14144 | 797-941 | STKc_BMPR1 |
| cd14067 | 798-949 | STKc_LRRK1 |
| cd14038 | 792-908 | STKc_IKK_beta |
| cd14119 | 809-898 | STKc_LKB1 |
| cd13977 | 806-894 | STKc_PDIK1L |
| cd07839 | 806-905 | STKc_CDK5 |
| cd08218 | 788-899 | STKc_Nek1 |
| cd14180 | 816-947 | STKc_MSK2_C |
| cd14091 | 605-908 | STKc_RSK_C |
| cd00096 | 231-297 | Ig |
| cd14054 | 798-898 | STKc_BMPR2_AMHR2 |
| cd14665 | 784-939 | STKc_SnRK2-3 |
| cd14189 | 809-919 | STKc_PLK3 |
| cd14133 | 806-898 | PKc_DYRK_like |
| cd14185 | 602-939 | STKc_DCKL3 |
| cd05632 | 806-904 | STKc_GRK5 |
| cd05631 | 804-904 | STKc_GRK4 |
| cd14197 | 809-915 | STKc_DRAK1 |
| cd14075 | 809-904 | STKc_NIM1 |
| cd14187 | 809-949 | STKc_PLK1 |
| cd07879 | 808-898 | STKc_p38delta |
| cd05609 | 813-940 | STKc_MAST |
| cd14094 | 809-920 | STKc_CASK |
| cd07835 | 805-903 | STKc_CDK1_CdkB_like |
| cd05608 | 794-901 | STKc_GRK1 |
| cd06645 | 798-913 | STKc_MAP4K3 |
| cd05595 | 806-904 | STKc_PKB_beta |
| cd07842 | 785-899 | STKc_CDK8_like |
| cd14106 | 790-904 | STKc_DRAK |
| cd14053 | 797-948 | STKc_ACVR2 |
| cd13995 | 802-905 | STKc_MAP3K8 |
| cd14190 | 763-904 | STKc_MLCK2 |
| cd14152 | 809-953 | STKc_KSR1 |
| cd14073 | 792-931 | STKc_NUAK |
| cd14161 | 792-904 | STKc_NUAK2 |
| cd05590 | 806-917 | STKc_nPKC_eta |
| cd07870 | 806-903 | STKc_PFTAIRE2 |
| cd14200 | 813-948 | STKc_CaMKK1 |
| cd06649 | 807-905 | PKc_MEK2 |
| cd05603 | 806-939 | STKc_SGK2 |
| cd14167 | 808-945 | STKc_CaMKI_alpha |
| cd14212 | 806-919 | PKc_YAK1 |
| cd14198 | 793-915 | STKc_DRAK2 |
| cd14097 | 810-920 | STKc_STK33 |
| cd06651 | 806-953 | STKc_MEKK3 |
| cd14199 | 791-948 | STKc_CaMKK2 |
| cd14045 | 783-953 | PK_GC_unk |
| cd14095 | 802-951 | STKc_DCKL |
| cd14135 | 820-898 | STKc_PRP4 |
| cd05586 | 814-920 | STKc_Sck1_like |
| cd14110 | 779-920 | STKc_obscurin_rpt2 |
| cd14078 | 805-920 | STKc_MELK |
| cd14086 | 808-920 | STKc_CaMKII |
| cd14026 | 808-951 | STKc_RIP2 |
| cd14072 | 602-939 | STKc_MARK |
| cd14220 | 824-941 | STKc_BMPR1a |
| cd14093 | 809-899 | STKc_PhKG |
| cd07865 | 809-898 | STKc_CDK9 |
| cd06658 | 810-919 | STKc_PAK5 |
| cd14107 | 784-892 | STKc_obscurin_rpt1 |
| cd14074 | 809-932 | STKc_SNRK |
| pfam00047 | 228-293 | ig |
| cd05615 | 804-903 | STKc_cPKC_alpha |
| cd00096 | 335-410 | Ig |
| cd14188 | 785-949 | STKc_PLK2 |
| cd14109 | 806-904 | PK_Unc-89_rpt1 |
| cd13982 | 787-904 | STKc_IRE1 |
| cd14056 | 798-950 | STKc_TGFbR_I |
| cd07850 | 798-896 | STKc_JNK |
| cd14183 | 802-904 | STKc_DCKL1 |
| cd14037 | 597-906 | STKc_NAK_like |
| cd14194 | 794-904 | STKc_DAPK1 |
| cd14071 | 808-894 | STKc_SIK |
| cd07874 | 808-896 | STKc_JNK3 |
| cd14004 | 809-907 | STKc_PASK |
| cd05606 | 797-904 | STKc_beta_ARK |
| cd14166 | 809-921 | STKc_CaMKI_gamma |
| cd05613 | 806-904 | STKc_MSK1_N |
| cd13990 | 809-949 | STKc_TLK |
| cd07875 | 808-919 | STKc_JNK1 |
| cd14142 | 824-941 | STKc_ACVR1_ALK1 |
| cd14663 | 809-898 | STKc_SnRK3 |
| cd14153 | 809-953 | PK_KSR2 |
| pfam00047 | 47-102 | ig |
| cl11960 | 47-102 | Ig superfamily |
| cd07844 | 806-922 | STKc_PCTAIRE_like |
| cd14223 | 792-904 | STKc_GRK2 |
| cd14662 | 806-932 | STKc_SnRK2 |
| cd14105 | 792-921 | STKc_DAPK |
| cd13998 | 797-948 | STKc_TGFbR-like |
| cd05584 | 814-904 | STKc_p70S6K |
| cd07869 | 806-896 | STKc_PFTAIRE1 |
| cd14096 | 809-903 | STKc_RCK1-like |
| cd14118 | 813-904 | STKc_CAMKK |
| cd14229 | 809-905 | STKc_HIPK3 |
| cd07868 | 788-943 | STKc_CDK8 |
| cd14046 | 809-895 | STKc_EIF2AK4_GCN2_rpt2 |
| cd05614 | 806-904 | STKc_MSK2_N |
| cd14196 | 798-904 | STKc_DAPK2 |
| cd14219 | 824-941 | STKc_BMPR1b |
| cd08216 | 808-908 | PK_STRAD |
| cd07876 | 808-896 | STKc_JNK2 |
| cd14005 | 809-953 | STKc_PIM |
| cd07867 | 788-943 | STKc_CDC2L6 |
| cd05593 | 806-904 | STKc_PKB_gamma |
| cd14143 | 807-941 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd13991 | 774-888 | STKc_NIK |
| cd06657 | 810-908 | STKc_PAK4 |
| cd14163 | 602-702 | STKc_TSSK3-like |
| cd05602 | 806-919 | STKc_SGK1 |
| cd14092 | 809-894 | STKc_MSK_C |
| cd14070 | 784-910 | STKc_HUNK |
| cd05594 | 806-904 | STKc_PKB_alpha |
| cd14169 | 808-945 | STKc_CaMKI_beta |
| cd14179 | 823-904 | STKc_MSK1_C |
| pfam13927 | 216-294 | Ig_3 |
| cd05571 | 814-896 | STKc_PKB |
| cd14213 | 605-658 | PKc_CLK1_4 |
| cd14195 | 791-904 | STKc_DAPK3 |
| cd07837 | 806-906 | STKc_CdkB_plant |
| cd14664 | 809-898 | STK_BAK1_like |
| cd14101 | 806-953 | STKc_PIM2 |
| cd05866 | 209-306 | Ig1_NCAM-2 |
| cd05604 | 806-903 | STKc_SGK3 |
| cd05633 | 792-904 | STKc_GRK3 |
| cd05624 | 823-944 | STKc_MRCK_beta |
| cd05575 | 806-895 | STKc_SGK |
| cd05607 | 806-904 | STKc_GRK7 |
| cd14168 | 809-939 | STKc_CaMKI_delta |
| cd05583 | 814-904 | STKc_MSK_N |
| cd05617 | 806-917 | STKc_aPKC_zeta |
| cd05598 | 823-903 | STKc_LATS |
| cd14046 | 606-698 | STKc_EIF2AK4_GCN2_rpt2 |
| cd05862 | 228-291 | Ig1_VEGFR |
| cd14170 | 810-943 | STKc_MAPKAPK2 |
| cd14020 | 810-898 | STKc_KIS |
| cd14089 | 808-894 | STKc_MAPKAPK |
| cd14182 | 814-903 | STKc_PhKG1 |
| cd14159 | 795-898 | STKc_IRAK1 |
| cd14083 | 809-893 | STKc_CaMKI |
| cd14087 | 810-904 | STKc_PSKH1 |
| cd14227 | 809-905 | STKc_HIPK2 |
| cd14125 | 809-855 | STKc_CK1_delta_epsilon |
| cd14172 | 810-939 | STKc_MAPKAPK3 |
| cd14224 | 806-908 | PKc_DYRK2_3 |
| cd14055 | 797-896 | STKc_TGFbR2_like |
| cd14228 | 809-905 | STKc_HIPK1 |
| cd04972 | 425-523 | Ig_TrkABC_d4 |
| cl11960 | 425-523 | Ig superfamily |
| cd14117 | 809-917 | STKc_Aurora-B_like |
| cd14114 | 794-892 | STKc_Twitchin_like |
| cd14036 | 599-696 | STKc_GAK |
| cd05588 | 806-904 | STKc_aPKC |
| cd14102 | 805-953 | STKc_PIM3 |
| cd14036 | 808-894 | STKc_GAK |
| cd14159 | 606-695 | STKc_IRAK1 |
| cd14083 | 597-691 | STKc_CaMKI |
| pfam07714 | 600-953 | Pkinase_Tyr |
| smart00410 | 222-310 | IG_like |
| smart00221 | 600-953 | STYKc |
| smart00219 | 600-953 | TyrKc |
| smart00220 | 602-953 | S_TKc |
| pfam00069 | 600-953 | Pkinase |
| COG0515 | 602-940 | SPS1 |
| smart00409 | 222-310 | IG |
| PTZ00036 | 806-905 | PTZ00036 |
| PTZ00024 | 809-939 | PTZ00024 |
| PLN00034 | 797-905 | PLN00034 |
| smart00408 | 227-298 | IGc2 |
| PTZ00267 | 808-899 | PTZ00267 |
| PTZ00283 | 809-899 | PTZ00283 |
| PTZ00263 | 806-909 | PTZ00263 |
| PTZ00426 | 806-904 | PTZ00426 |
| PHA02988 | 875-949 | PHA02988 |
| PHA03209 | 791-914 | PHA03209 |
| pfam07679 | 224-310 | I-set |
| PHA03390 | 808-904 | pk1 |
| PLN00009 | 806-906 | PLN00009 |
| PRK13184 | 809-904 | pknD |
| PHA03212 | 802-898 | PHA03212 |
| PTZ00266 | 823-920 | PTZ00266 |
| TIGR03903 | 783-898 | TOMM_kin_cyc |
| pfam07679 | 335-413 | I-set |
| smart00409 | 40-110 | IG |
| smart00410 | 40-110 | IG_like |
| PHA03211 | 798-929 | PHA03211 |
| smart00409 | 335-413 | IG |
| smart00410 | 335-413 | IG_like |
| smart00408 | 335-395 | IGc2 |
Ontology Information
| HPRD ID | 1495 |
|---|---|
| Molecular Class | Receptor tyrosine kinase |
| Molecular Function | Protein-tyrosine kinase activity (GO:0004713) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165); Immune response (GO:0006955) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P09619 | DB00102 | Becaplermin | BiotechDrug |
| P09619 | DB00398 | Sorafenib | SmallMoleculeDrug |
| P09619 | DB00619 | Imatinib | SmallMoleculeDrug |
| P09619 | DB01254 | Dasatinib | SmallMoleculeDrug |
| P09619 | DB01268 | Sunitinib | SmallMoleculeDrug |
| P09619 | DB06589 | Pazopanib | SmallMoleculeDrug |
| P09619 | DB08896 | Regorafenib | SmallMoleculeDrug |