Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SUFU | 51684 | suppressor of fused homolog (Drosophila) | 10 | SUFUH, SUFUXL, PRO1280 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23551431 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 127 colon cancer, 36 with melanosis coli and 20 adjacent normal tissues Stage : - | real time RT-PCR, Western Blotting | Up-regulation | - | Elevated Sufu protein levels were positively correlated with the diameter and invasion of the tumor. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| Chromosome | 10 |
| Location | 10q24.32 |
| Start | 104263719 |
| End | 104393214 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 129496 |
| OMIM ID | 607035 |
| HGNC ID | HGNC:16466 |
| Unigene ID | Hs.404089 |
| Ensembl ID | ENSG00000107882 |
| PharmGKB ID | PA38146 |
Protein Information
| Protein ID | NP_001171604.1 |
|---|---|
| Protein Name | suppressor of fused homolog (Drosophila) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 484 |
| Uniprot ID | Q9UJQ4 |
| Ensembl Protein ID | ENSP00000217086 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 481 |
| K | Acetylation | 303 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2735 | GLI1 | 1311 | NP_005260.1 | in vitro;in vivo | 1 055 994 512 426 310 |
| 2736 | GLI2 | 1312 | NP_005261.2 | in vitro | 10564661 |
| 2737 | GLI3 | 1313 | P10071 | in vitro | 10564661 |
| 3159 | HMGA1 | 2829 | NP_665906.1 | yeast 2-hybrid | 14611647 |
| 3178 | HNRNPA1 | 1242 | NP_112420.1 | yeast 2-hybrid | 14611647 |
| 3516 | RBPJ | 920 | NP_005340.2 | yeast 2-hybrid | 14611647 |
| 3958 | LGALS3 | 1090 | NP_002297.2 | in vitro;yeast 2-hybrid | 14611647 |
| 8202 | NCOA3 | 3570 | NP_858045.1 | yeast 2-hybrid | 14611647 |
| 8649 | MAPKSP1 | 4485 | NP_068805.1 | yeast 2-hybrid | 14611647 |
| 8945 | BTRC | 4596 | NP_378663.1 | in vitro;in vivo | 10564661 |
| 9869 | SETDB1 | 6828 | NP_001138887.1 | yeast 2-hybrid | 14611647 |
| 10284 | SAP18 | 4256 | NP_005861.2 | in vitro;in vivo;yeast 2-hybrid | 1 196 000 014 611 640 |
| 23475 | QPRT | 6950 | NP_055113.2 | yeast 2-hybrid | 16189514 |
| 51222 | ZNF219 | 5435 | NP_057507.2 | yeast 2-hybrid | 14611647 |
| 55663 | ZNF446 | 7934 | NP_060378.1 | yeast 2-hybrid | 16189514 |
| 55670 | PEX26 | 10559 | NP_060399.1 | yeast 2-hybrid | 16189514 |
| 57333 | RCN3 | 17962 | NP_065701.2 | yeast 2-hybrid | 16189514 |
| 58526 | MID1IP1 | 6732 | NP_067065.1 | yeast 2-hybrid | 16189514 |
| 92595 | ZNF764 | 10072 | NP_219363.1 | yeast 2-hybrid | 16189514 |
| 169792 | GLIS3 | 13582 | NP_001035878.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hedgehog signaling pathway | hsa04340 |
| Pathways in cancer | hsa05200 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam12470 | 252-473 | SUFU_C |
| cl13854 | 252-473 | SUFU_C superfamily |
| pfam05076 | 63-240 | SUFU |
| cl04922 | 63-240 | SUFU superfamily |
Ontology Information
| HPRD ID | 10467 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.