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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ENPP3 | 5169 | ectonucleotide pyrophosphatase/phosphodiesterase 3 | 6 | PD-IBETA, gp130RB13-6, B10, CD203c |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 14533006 | 2003 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Western blotting ,Immunohistochemistry | Up-regulation | - | E-NPP3 is associated with carcinogenesis of human colon cancer and that serum E-NPP3 might be a tumor marker of colon carcinoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015] |
| Chromosome | 6 |
| Location | 6q22 |
| Start | 131958375 |
| End | 132068550 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 110176 |
| OMIM ID | 602182 |
| HGNC ID | HGNC:3358 |
| Unigene ID | Hs.486489 |
| Ensembl ID | ENSG00000154269 |
| PharmGKB ID | PA27793 |
mRNA Information
| mRNA ID | NM_005021.4 |
|---|---|
| Exon | join(68..228,4221..4296,12793..12915,15308..15433, 15597..15657,21089..21186,34014..34093,36928..37047, 37846..37955,39502..39567,40634..40706,45820..45928, 48130..48261,48642..48673,56263..56390,81438..81504, 83058..83145,84993..85171,86806..86857,88812..88966, 96354..96489,100121..100198,100797..100929,102990..103146, 109552..110176) | mRNA Sequence | Download Select all |
| Length | 3247 |
Protein Information
| Protein ID | NP_005012.2 |
|---|---|
| Protein Name | ectonucleotide pyrophosphatase/phosphodiesterase 3 |
| Molecular Wt. (Da) | 136081 |
| Protein Sequence | Download Select all |
| Length | 875 |
| Uniprot ID | P17010 |
| Ensembl Protein ID | ENSP00000304985 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolic pathways | hsa01100 |
| Nicotinate and nicotinamide metabolism | hsa00760 |
| Pantothenate and CoA biosynthesis | hsa00770 |
| Purine metabolism | hsa00230 |
| Starch and sucrose metabolism | hsa00500 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00091 | 608-867 | NUC |
| cl00089 | 608-867 | NUC superfamily |
| pfam01663 | 161-486 | Phosphodiest |
| cl21476 | 161-486 | alkPPc superfamily |
| smart00477 | 627-857 | NUC |
| smart00892 | 630-855 | Endonuclease_NS |
| pfam01033 | 95-138 | Somatomedin_B |
| cl02508 | 95-138 | Somatomedin_B superfamily |
| smart00201 | 94-137 | SO |
| smart00201 | 51-93 | SO |
| cl02508 | 51-93 | Somatomedin_B superfamily |
| pfam01033 | 50-94 | Somatomedin_B |
| pfam01223 | 630-850 | Endonuclease_NS |
| pfam01676 | 321-388 | Metalloenzyme |
| TIGR02335 | 160-230 | hydr_PhnA |
| COG1524 | 147-539 | Npp1 |
| PTZ00259 | 624-853 | PTZ00259 |
Ontology Information
| HPRD ID | 3296 |
|---|---|
| Molecular Class | Enzyme: Phosphodiesterase |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.