Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PDPK1 | 5170 | 3-phosphoinositide dependent protein kinase-1 | 16 | PDK1; PDPK2; PRO0461 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20133737 | 2010 | Cell line : - Source : ATCC Sample Type : - No. of Sample : - Stage : - | Colony-Formation Assays, Apoptosis Assays, Western Blotting and Metastasis Assays | Phosphorylation | - | Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. Inactivation of PDPK1 affected GSK3beta and mTOR activation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - |
| Chromosome | 16 |
| Location | 16p13.3 |
| Start | 2537964 |
| End | 2603191 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 65228 |
| OMIM ID | 605213 |
| HGNC ID | HGNC:8816 |
| Unigene ID | Hs.459691 |
| Ensembl ID | ENSG00000140992 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002613.4 |
|---|---|
| Exon | join(1..173,19740..20000,23517..23559,23808..23945, 27590..27734,28393..28490,39462..39537,43332..43400, 43644..43740,45449..45622,48713..48930,57830..57887, 59160..59312,59688..65227) | mRNA Sequence | Download Select all |
| Length | 7243 |
CDS Information
| Location | join(150..173,19740..20000,23517..23559,23808..23945, 27590..27734,28393..28490,39462..39537,43332..43400, 43644..43740,45449..45622,48713..48930,57830..57887, 59160..59312,59688..59804) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS10472.1 |
Protein Information
| Protein ID | NP_001248745.1 |
|---|---|
| Protein Name | 3-phosphoinositide dependent protein kinase-1 |
| Molecular Wt. (Da) | 50707 |
| Protein Sequence | Download Select all |
| Length | 454 |
| Uniprot ID | P09543 |
| Ensembl Protein ID | ENSP00000377466 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 25 |
| S | Phosphorylation | 393 |
| S | Phosphorylation | 396 |
| S | Phosphorylation | 410 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 266 |
| S | Phosphorylation | 269 |
| S | Phosphorylation | 283 |
| Y | Phosphorylation | 373 |
| Y | Phosphorylation | 485 |
| Y | Phosphorylation | 9 |
| Y | Phosphorylation | 246 |
| Y | Phosphorylation | 358 |
| Y | Phosphorylation | 9 |
| S | Phosphorylation | 241 |
| T | Phosphorylation | 33 |
| T | Phosphorylation | 513 |
| S | Phosphorylation | 114 |
| T | Phosphorylation | 33 |
| T | Phosphorylation | 386 |
| S | Phosphorylation | 241 |
| S | Phosphorylation | 114 |
| S | Phosphorylation | 241;- |
| S | Phosphorylation | 114;- |
| T | Phosphorylation | 245;- |
| T | Phosphorylation | 118;- |
| T | Phosphorylation | 37 |
| T | Phosphorylation | 37 |
| K | Acetylation | 304 |
| K | Acetylation | 177 |
| S | Phosphorylation | 501 |
| S | Phosphorylation | 374 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 207 | AKT1 | 1261 | NP_005154.2 | in vitro;in vivo | 11 825 911 114 387 200 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 |
| 208 | AKT2 | 1262 | AAA36585.1 | in vitro;in vivo | 1 204 820 393 745 420 000 000 |
| 2475 | MTOR | 3134 | NP_004949.1 | in vitro | 11438723 |
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vitro;in vivo | 11779851 |
| 3611 | ILK | 3842 | NP_004508.1 | in vivo | 11313365 |
| 3690 | ITGB3 | 1428 | NP_000203.2 | in vitro | 10896934 |
| 5058 | PAK1 | 3995 | AAC24716.1 | in vitro | 10995762 |
| 5566 | PRKACA | 3382 | NP_002721.1 | in vitro;yeast 2-hybrid | 10698939 |
| 5579 | PRKCB | 1499 | NP_002729.2 | in vivo | 11376011 |
| 5580 | PRKCD | 1501 | NP_006245.2 | in vitro;in vivo;yeast 2-hybrid | 11 781 095 113 811 100 000 000 |
| 5581 | PRKCE | 1500 | NP_005391.1 | in vitro;in vivo | 110 620 541 264 046 000 000 000 |
| 5584 | PRKCI | 2105 | NP_002731.4 | in vivo;yeast 2-hybrid | 10764742 |
| 5585 | PKN1 | 3019 | NP_998725.1 | in vitro;in vivo;yeast 2-hybrid | 107 647 421 079 204 000 000 000 |
| 5586 | PKN2 | 3972 | NP_006247.1 | in vitro;in vivo | 10753910 |
| 5590 | PRKCZ | 1504 | NP_002735.3 | in vitro;in vivo;yeast 2-hybrid | 11 781 095 974 816 600 000 000 000 000 000 000 000 000 000 000 |
| 5900 | RALGDS | 3371 | NP_006257.1 | in vitro;in vivo | 11889038 |
| 6195 | RPS6KA1 | 3402 | NP_001006666.1 | in vitro;in vivo | 104 809 339 430 688 |
| 6197 | RPS6KA3 | 2092 | NP_004577.1 | in vivo | 10856237 |
| 6198 | RPS6KB1 | 10202 | NP_003152.1 | in vitro;in vivo | 1 143 872 310 601 310 000 000 000 000 000 000 000 |
| 6199 | RPS6KB2 | 10203 | NP_003943.2 | in vitro | 11733037 |
| 6446 | SGK1 | 4264 | NP_001137148.1 | in vitro;in vivo | 1 035 781 510 191 260 |
| 7533 | YWHAH | 215 | NP_003396.1 | in vitro;in vivo | 12177059 |
| 10000 | AKT3 | 6441 | NP_005456.1 | in vitro;in vivo | 121 627 519 512 493 |
| 10110 | SGK2 | 6348 | NP_057360.2 | in vitro | 10548550 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vitro;in vivo | 12177059 |
| 11098 | PRSS23 | 7149 | NP_009104.1 | yeast 2-hybrid | 16169070 |
| 11171 | STRAP | 5816 | NP_009109.3 | in vivo;yeast 2-hybrid | 16251192 |
| 23678 | SGK3 | 6349 | NP_037389.4 | in vitro | 10548550 |
| 146059 | CDAN1 | 8470 | NP_612486.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Aldosterone-regulated sodium reabsorption | hsa04960 |
| AMPK signaling pathway | hsa04152 |
| Choline metabolism in cancer | hsa05231 |
| Endometrial cancer | hsa05213 |
| Fc epsilon RI signaling pathway | hsa04664 |
| Focal adhesion | hsa04510 |
| FoxO signaling pathway | hsa04068 |
| Hepatitis C | hsa05160 |
| Insulin resistance | hsa04931 |
| Insulin signaling pathway | hsa04910 |
| mTOR signaling pathway | hsa04150 |
| Neurotrophin signaling pathway | hsa04722 |
| Non-small cell lung cancer | hsa05223 |
| PI3K-Akt signaling pathway | hsa04151 |
| PPAR signaling pathway | hsa03320 |
| Prostate cancer | hsa05215 |
| Proteoglycans in cancer | hsa05205 |
| Sphingolipid signaling pathway | hsa04071 |
| T cell receptor signaling pathway | hsa04660 |
| Thyroid hormone signaling pathway | hsa04919 |
| Toxoplasmosis | hsa05145 |
Structure Information
| PDB ID | 1H1W |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05581 | 80-342 | STKc_PDK1 |
| cl21453 | 80-342 | PKc_like superfamily |
| cd01262 | 441-547 | PH_PDK1 |
| cl17171 | 441-547 | PH-like superfamily |
| cd05123 | 88-342 | STKc_AGC |
| cd05580 | 80-352 | STKc_PKA_like |
| cd05579 | 91-347 | STKc_MAST_like |
| cd05117 | 81-341 | STKc_CAMK |
| cd14007 | 81-341 | STKc_Aurora |
| cd05612 | 80-377 | STKc_PRKX_like |
| cd05574 | 81-370 | STKc_phototropin_like |
| cd05573 | 80-373 | STKc_ROCK_NDR_like |
| cd05572 | 88-348 | STKc_cGK |
| cd05575 | 86-356 | STKc_SGK |
| cd05570 | 86-356 | STKc_PKC |
| cd14003 | 81-341 | STKc_AMPK-like |
| cd05598 | 81-377 | STKc_LATS |
| cd14209 | 80-354 | STKc_PKA |
| cd05599 | 80-369 | STKc_NDR_like |
| cd05585 | 87-366 | STKc_YPK1_like |
| cd05571 | 86-356 | STKc_PKB |
| cd05611 | 86-348 | STKc_Rim15_like |
| cd05584 | 86-370 | STKc_p70S6K |
| cd05578 | 82-342 | STKc_Yank1 |
| cd05595 | 86-370 | STKc_PKB_beta |
| cd05601 | 80-370 | STKc_CRIK |
| cd08215 | 81-324 | STKc_Nek |
| cd05583 | 87-345 | STKc_MSK_N |
| cd05602 | 81-356 | STKc_SGK1 |
| cd05592 | 86-356 | STKc_nPKC_theta_like |
| cd05590 | 86-356 | STKc_nPKC_eta |
| cd06606 | 81-342 | STKc_MAPKKK |
| cd14663 | 81-341 | STKc_SnRK3 |
| cd05614 | 81-350 | STKc_MSK2_N |
| cd05603 | 86-356 | STKc_SGK2 |
| cd14008 | 88-342 | STKc_LKB1_CaMKK |
| cd14099 | 80-342 | STKc_PLK |
| cd05604 | 86-356 | STKc_SGK3 |
| cd05587 | 86-350 | STKc_cPKC |
| cd05582 | 86-373 | STKc_RSK_N |
| cd05591 | 86-356 | STKc_nPKC_epsilon |
| cd05613 | 81-356 | STKc_MSK1_N |
| pfam14593 | 446-548 | PH_3 |
| cd05616 | 81-382 | STKc_cPKC_beta |
| cd05610 | 80-356 | STKc_MASTL |
| cd05593 | 81-356 | STKc_PKB_gamma |
| cd05577 | 88-356 | STKc_GRK |
| cd14080 | 82-342 | STKc_TSSK-like |
| cd05619 | 80-377 | STKc_nPKC_theta |
| cd05594 | 81-356 | STKc_PKB_alpha |
| cd05597 | 80-377 | STKc_DMPK_like |
| cd05615 | 81-356 | STKc_cPKC_alpha |
| cd05629 | 80-363 | STKc_NDR_like_fungal |
| cd05586 | 88-356 | STKc_Sck1_like |
| cd00180 | 88-330 | PKc |
| cd05596 | 80-370 | STKc_ROCK |
| cd14014 | 86-324 | STKc_PknB_like |
| cd05605 | 82-350 | STKc_GRK4_like |
| cd05620 | 86-377 | STKc_nPKC_delta |
| cd05609 | 81-347 | STKc_MAST |
| cd05626 | 86-366 | STKc_LATS2 |
| cd14081 | 82-342 | STKc_BRSK1_2 |
| cd14116 | 80-325 | STKc_Aurora-A |
| cd05600 | 81-356 | STKc_Sid2p_like |
| cd14095 | 82-330 | STKc_DCKL |
| cd05589 | 82-356 | STKc_PKN |
| cd05122 | 81-342 | PKc_STE |
| cd05631 | 82-356 | STKc_GRK4 |
| cd14083 | 82-329 | STKc_CaMKI |
| cd14098 | 81-324 | STKc_Rad53_Cds1 |
| cd05630 | 82-350 | STKc_GRK6 |
| cd14009 | 88-341 | STKc_ATG1_ULK_like |
| cd14186 | 80-341 | STKc_PLK4 |
| cd05632 | 82-350 | STKc_GRK5 |
| cd05606 | 87-356 | STKc_beta_ARK |
| cd14072 | 82-324 | STKc_MARK |
| cd05618 | 80-383 | STKc_aPKC_iota |
| cd05588 | 86-368 | STKc_aPKC |
| cd14006 | 88-329 | STKc_MLCK-like |
| cd14167 | 80-329 | STKc_CaMKI_alpha |
| cd05617 | 80-383 | STKc_aPKC_zeta |
| cd06627 | 82-342 | STKc_Cdc7_like |
| cd05622 | 80-379 | STKc_ROCK1 |
| cd14117 | 80-339 | STKc_Aurora-B_like |
| cd05625 | 86-366 | STKc_LATS1 |
| cd05621 | 80-379 | STKc_ROCK2 |
| cd05624 | 80-377 | STKc_MRCK_beta |
| cd14002 | 80-341 | STKc_STK36 |
| cd14092 | 86-359 | STKc_MSK_C |
| cd14093 | 87-342 | STKc_PhKG |
| cd14169 | 88-329 | STKc_CaMKI_beta |
| cd08529 | 81-324 | STKc_FA2-like |
| cd14223 | 81-377 | STKc_GRK2 |
| cd06623 | 80-341 | PKc_MAPKK_plant_like |
| cd05633 | 81-377 | STKc_GRK3 |
| cd06632 | 85-341 | STKc_MEKK1_plant |
| cd14071 | 86-330 | STKc_SIK |
| cd05623 | 80-379 | STKc_MRCK_alpha |
| cd14166 | 80-329 | STKc_CaMKI_gamma |
| cd14084 | 86-329 | STKc_Chk2 |
| cd05608 | 81-356 | STKc_GRK1 |
| cd05627 | 80-353 | STKc_NDR2 |
| cd14078 | 88-330 | STKc_MELK |
| cd14162 | 82-330 | STKc_TSSK4-like |
| cd14073 | 82-324 | STKc_NUAK |
| cd14079 | 82-342 | STKc_AMPK_alpha |
| cd06626 | 85-341 | STKc_MEKK4 |
| cd14087 | 87-325 | STKc_PSKH1 |
| cd14075 | 82-330 | STKc_NIM1 |
| cd14096 | 80-341 | STKc_RCK1-like |
| cd14085 | 82-329 | STKc_CaMKIV |
| cd08217 | 81-342 | STKc_Nek2 |
| cd08224 | 81-324 | STKc_Nek6_7 |
| cd14090 | 85-329 | STKc_Mnk |
| cd14185 | 82-324 | STKc_DCKL3 |
| cd14189 | 85-342 | STKc_PLK3 |
| cd08220 | 86-324 | STKc_Nek8 |
| cd13999 | 88-283 | STKc_MAP3K-like |
| cd14179 | 86-325 | STKc_MSK1_C |
| cd14103 | 88-329 | STKc_MLCK |
| cd14119 | 88-342 | STKc_LKB1 |
| cd14188 | 85-317 | STKc_PLK2 |
| cd14086 | 88-353 | STKc_CaMKII |
| cd05628 | 80-353 | STKc_NDR1 |
| cd14187 | 85-330 | STKc_PLK1 |
| cd14168 | 80-329 | STKc_CaMKI_delta |
| cd14137 | 82-342 | STKc_GSK3 |
| cd14165 | 82-342 | STKc_TSSK1_2-like |
| cd14074 | 82-332 | STKc_SNRK |
| cd07833 | 88-342 | STKc_CDKL |
| cd14069 | 80-342 | STKc_Chk1 |
| cd06610 | 80-342 | STKc_OSR1_SPAK |
| cd14173 | 86-330 | STKc_Mnk2 |
| cd14181 | 87-342 | STKc_PhKG2 |
| cd14010 | 88-341 | STKc_ULK4 |
| cd14161 | 82-333 | STKc_NUAK2 |
| cd06614 | 82-343 | STKc_PAK |
| cd14118 | 87-340 | STKc_CAMKK |
| cd14076 | 85-325 | STKc_Kin4 |
| cd06625 | 83-342 | STKc_MEKK3_like |
| cd14077 | 81-329 | STKc_Kin1_2 |
| cd14091 | 88-325 | STKc_RSK_C |
| cd08530 | 81-330 | STKc_CNK2-like |
| cd14113 | 88-324 | STKc_Trio_C |
| cd06609 | 80-341 | STKc_MST3_like |
| cd14196 | 80-329 | STKc_DAPK2 |
| cd13996 | 80-329 | STKc_EIF2AK |
| cd13994 | 88-325 | STKc_HAL4_like |
| cd14182 | 80-343 | STKc_PhKG1 |
| cd07829 | 82-342 | STKc_CDK_like |
| cd14184 | 80-330 | STKc_DCKL2 |
| cd05607 | 86-350 | STKc_GRK7 |
| cd14097 | 82-330 | STKc_STK33 |
| cd14120 | 88-341 | STKc_ULK1_2-like |
| cd05118 | 88-342 | STKc_CMGC |
| cd14180 | 88-331 | STKc_MSK2_C |
| cd14174 | 86-325 | STKc_Mnk1 |
| cd14194 | 80-325 | STKc_DAPK1 |
| cd14106 | 85-329 | STKc_DRAK |
| cd14046 | 81-330 | STKc_EIF2AK4_GCN2_rpt2 |
| cd14105 | 80-329 | STKc_DAPK |
| cd14201 | 81-343 | STKc_ULK2 |
| cd08222 | 88-324 | STKc_Nek11 |
| cd08218 | 86-317 | STKc_Nek1 |
| cd06628 | 85-341 | STKc_Byr2_like |
| cd06612 | 80-342 | STKc_MST1_2 |
| cd14195 | 82-325 | STKc_DAPK3 |
| cd06647 | 83-343 | STKc_PAK_I |
| cd14070 | 85-329 | STKc_HUNK |
| cd14082 | 86-328 | STKc_PKD |
| cd13993 | 82-319 | STKc_Pat1_like |
| cd14183 | 80-324 | STKc_DCKL1 |
| cd07830 | 82-342 | STKc_MAK_like |
| cd06630 | 85-342 | STKc_MEKK1 |
| cd07832 | 85-342 | STKc_CCRK |
| cd14121 | 88-341 | STKc_ULK3 |
| cd14199 | 82-341 | STKc_CaMKK2 |
| cd07838 | 87-342 | STKc_CDK4_6_like |
| cd08221 | 86-330 | STKc_Nek9 |
| cd06613 | 81-342 | STKc_MAP4K3_like |
| cd14202 | 82-343 | STKc_ULK1 |
| cd08528 | 88-324 | STKc_Nek10 |
| cd06605 | 80-342 | PKc_MAPKK |
| cd08219 | 81-324 | STKc_Nek3 |
| cd06611 | 88-346 | STKc_SLK_like |
| cd14163 | 82-282 | STKc_TSSK3-like |
| cd08223 | 81-324 | STKc_Nek4 |
| cd14665 | 82-333 | STKc_SnRK2-3 |
| cd14164 | 82-282 | STKc_TSSK6-like |
| cd14094 | 87-329 | STKc_CASK |
| cd14114 | 88-325 | STKc_Twitchin_like |
| cd14133 | 86-342 | PKc_DYRK_like |
| cd08225 | 86-294 | STKc_Nek5 |
| cd14004 | 81-342 | STKc_PASK |
| cd06655 | 88-343 | STKc_PAK2 |
| cd06629 | 85-341 | STKc_Bck1_like |
| cd14190 | 86-325 | STKc_MLCK2 |
| cd08228 | 81-324 | STKc_Nek6 |
| cd14193 | 86-329 | STKc_MLCK4 |
| cd07840 | 87-325 | STKc_CDK9_like |
| cd07831 | 85-342 | STKc_MOK |
| cd13978 | 88-296 | STKc_RIP |
| cd07834 | 82-345 | STKc_MAPK |
| cd14109 | 99-329 | PK_Unc-89_rpt1 |
| cd14200 | 82-341 | STKc_CaMKK1 |
| cd14662 | 86-341 | STKc_SnRK2 |
| cd13985 | 86-324 | STKc_GAK_like |
| cd06648 | 84-342 | STKc_PAK_II |
| cd14192 | 86-325 | STKc_MLCK3 |
| cd13989 | 88-282 | STKc_IKK |
| cd14048 | 81-324 | STKc_EIF2AK3_PERK |
| cd14175 | 88-330 | STKc_RSK1_C |
| cd06654 | 83-346 | STKc_PAK1 |
| cd13990 | 87-324 | STKc_TLK |
| cd14178 | 88-325 | STKc_RSK3_C |
| cd06656 | 83-343 | STKc_PAK3 |
| cd14191 | 88-329 | STKc_MLCK1 |
| cd06659 | 88-342 | STKc_PAK6 |
| cd13987 | 88-333 | STKc_SBK1 |
| cd14104 | 82-329 | STKc_Titin |
| cd06653 | 80-341 | STKc_MEKK3_like_u1 |
| cd06631 | 82-341 | STKc_YSK4 |
| cd14176 | 88-325 | STKc_RSK2_C |
| cd06608 | 80-341 | STKc_myosinIII_N_like |
| cd06641 | 80-281 | STKc_MST3 |
| cd06624 | 87-341 | STKc_ASK |
| cd13986 | 82-324 | STKc_16 |
| cd14088 | 82-329 | STKc_CaMK_like |
| cd14171 | 81-330 | STKc_MAPKAPK5 |
| cd06917 | 82-339 | STKc_NAK1_like |
| cd14089 | 85-329 | STKc_MAPKAPK |
| cd14115 | 88-324 | STKc_Kalirin_C |
| cd06644 | 88-346 | STKc_STK10 |
| cd06620 | 80-324 | PKc_Byr1_like |
| cd07851 | 88-344 | STKc_p38 |
| cd14131 | 86-341 | PKc_Mps1 |
| cd07852 | 131-343 | STKc_MAPK15-like |
| cd07849 | 80-344 | STKc_ERK1_2_like |
| cd14038 | 88-282 | STKc_IKK_beta |
| cd07841 | 82-342 | STKc_CDK7 |
| cd06651 | 81-341 | STKc_MEKK3 |
| cd14197 | 85-329 | STKc_DRAK1 |
| cd08229 | 81-324 | STKc_Nek7 |
| cd07847 | 83-342 | STKc_CDKL1_4 |
| cd06640 | 88-281 | STKc_MST4 |
| cd14107 | 88-342 | STKc_obscurin_rpt1 |
| cd06652 | 81-330 | STKc_MEKK2 |
| cd06618 | 80-341 | PKc_MKK7 |
| cd14005 | 82-342 | STKc_PIM |
| cd14039 | 88-282 | STKc_IKK_alpha |
| cd14198 | 86-324 | STKc_DRAK2 |
| cd07855 | 92-358 | STKc_ERK5 |
| cd14177 | 88-285 | STKc_RSK4_C |
| cd14066 | 88-282 | STKc_IRAK |
| cd07836 | 88-342 | STKc_Pho85 |
| cd06642 | 88-324 | STKc_STK25 |
| cd07857 | 82-329 | STKc_MPK1 |
| cd06643 | 88-346 | STKc_SLK |
| cd14047 | 80-324 | STKc_EIF2AK2_PKR |
| cd07880 | 86-356 | STKc_p38gamma |
| cd14132 | 80-343 | STKc_CK2_alpha |
| cd14108 | 88-342 | STKc_SPEG_rpt1 |
| cd05576 | 91-342 | STKc_RPK118_like |
| cd14172 | 80-329 | STKc_MAPKAPK3 |
| cd07846 | 87-342 | STKc_CDKL2_3 |
| cd07848 | 82-329 | STKc_CDKL5 |
| cd14101 | 82-330 | STKc_PIM2 |
| cd06621 | 87-341 | PKc_Pek1_like |
| cd14016 | 82-250 | STKc_CK1 |
| cd13974 | 179-325 | STKc_SHIK |
| cd14110 | 82-284 | STKc_obscurin_rpt2 |
| cd07835 | 83-342 | STKc_CDK1_CdkB_like |
| cd07877 | 88-342 | STKc_p38alpha |
| cd00192 | 86-324 | PTKc |
| cd13983 | 82-342 | STKc_WNK |
| cd14111 | 89-308 | STKc_SPEG_rpt2 |
| cd07856 | 88-329 | STKc_Sty1_Hog1 |
| cd07878 | 88-342 | STKc_p38beta |
| cd07854 | 88-341 | STKc_MAPK4_6 |
| cd07873 | 88-352 | STKc_PCTAIRE1 |
| cd07871 | 83-328 | STKc_PCTAIRE3 |
| cd13982 | 86-342 | STKc_IRE1 |
| cd06615 | 80-287 | PKc_MEK |
| cd06636 | 82-282 | STKc_MAP4K4_6_N |
| cd14041 | 87-330 | STKc_TLK2 |
| cd13979 | 83-292 | STKc_Mos |
| cd07879 | 86-344 | STKc_p38delta |
| cd14019 | 80-342 | STKc_Cdc7 |
| cd07858 | 86-344 | STKc_TEY_MAPK |
| cd14112 | 80-329 | STKc_Unc-89_rpt2 |
| cd14027 | 130-314 | STKc_RIP1 |
| cd07860 | 83-342 | STKc_CDK2_3 |
| cd07864 | 82-329 | STKc_CDK12 |
| cd07842 | 82-342 | STKc_CDK8_like |
| cd13997 | 81-289 | PKc_Wee1_like |
| cd05038 | 83-275 | PTKc_Jak_rpt2 |
| cd06650 | 80-358 | PKc_MEK1 |
| cd06658 | 88-343 | STKc_PAK5 |
| cd06622 | 88-344 | PKc_PBS2_like |
| cd07866 | 80-342 | STKc_BUR1 |
| cd07844 | 88-342 | STKc_PCTAIRE_like |
| cd07863 | 88-342 | STKc_CDK4 |
| cd06645 | 80-281 | STKc_MAP4K3 |
| cd06657 | 88-342 | STKc_PAK4 |
| cd05057 | 82-275 | PTKc_EGFR_like |
| cd14170 | 80-356 | STKc_MAPKAPK2 |
| cd07870 | 88-282 | STKc_PFTAIRE2 |
| cd14058 | 88-332 | STKc_TAK1 |
| cd14040 | 87-304 | STKc_TLK1 |
| cd14037 | 86-324 | STKc_NAK_like |
| cd07872 | 84-282 | STKc_PCTAIRE2 |
| cd14134 | 82-342 | PKc_CLK |
| cd13995 | 90-330 | STKc_MAP3K8 |
| cd14211 | 88-288 | STKc_HIPK |
| cd14229 | 88-288 | STKc_HIPK3 |
| cd14210 | 86-297 | PKc_DYRK |
| cd14052 | 81-277 | PTKc_Wee1_fungi |
| cd07839 | 83-342 | STKc_CDK5 |
| cd14212 | 87-295 | PKc_YAK1 |
| cd07862 | 88-317 | STKc_CDK6 |
| cd05072 | 80-276 | PTKc_Lyn |
| cd06646 | 80-281 | STKc_MAP4K5 |
| cd14100 | 82-333 | STKc_PIM1 |
| cd06635 | 88-282 | STKc_TAO1 |
| cd06633 | 88-282 | STKc_TAO3 |
| cd05059 | 81-275 | PTKc_Tec_like |
| cd05082 | 80-324 | PTKc_Csk |
| cd06638 | 88-324 | STKc_myosinIIIA_N |
| cd06637 | 82-341 | STKc_TNIK |
| cd07869 | 88-282 | STKc_PFTAIRE1 |
| cd05039 | 80-275 | PTKc_Csk_like |
| cd06607 | 88-282 | STKc_TAO |
| cd07843 | 90-342 | STKc_CDC2L1 |
| cd14011 | 189-344 | PK_SCY1_like |
| cd14050 | 82-330 | PKc_Myt1 |
| cd05108 | 81-282 | PTKc_EGFR |
| cd14205 | 82-275 | PTKc_Jak2_rpt2 |
| cd07845 | 83-297 | STKc_CDK10 |
| cd14036 | 86-325 | STKc_GAK |
| cd05035 | 82-282 | PTKc_TAM |
| cd05060 | 88-283 | PTKc_Syk_like |
| cd07859 | 82-345 | STKc_TDY_MAPK |
| cd06649 | 80-310 | PKc_MEK2 |
| cd14059 | 159-283 | STKc_MAP3K12_13 |
| cd14227 | 86-288 | STKc_HIPK2 |
| cd06634 | 88-282 | STKc_TAO2 |
| cd07853 | 183-343 | STKc_NLK |
| cd14065 | 88-289 | PKc_LIMK_like |
| cd06619 | 80-282 | PKc_MKK5 |
| cd14022 | 155-342 | PK_TRB2 |
| cd07861 | 83-342 | STKc_CDK1_euk |
| cd14228 | 86-288 | STKc_HIPK1 |
| cd14102 | 82-330 | STKc_PIM3 |
| cd14158 | 85-282 | STKc_IRAK4 |
| cd14145 | 86-284 | STKc_MLK1 |
| cd14135 | 88-310 | STKc_PRP4 |
| cd13988 | 88-283 | STKc_TBK1 |
| cd07875 | 86-356 | STKc_JNK1 |
| cd07850 | 86-329 | STKc_JNK |
| cd06616 | 88-342 | PKc_MKK4 |
| cd05074 | 82-306 | PTKc_Tyro3 |
| cd14136 | 88-278 | STKc_SRPK |
| cd14146 | 87-284 | STKc_MLK4 |
| cd14226 | 86-316 | PKc_DYRK1 |
| cd14033 | 82-342 | STKc_WNK4 |
| cd05045 | 84-286 | PTKc_RET |
| cd14060 | 89-283 | STKc_MLTK |
| cd14061 | 87-283 | STKc_MLK |
| cd05068 | 83-276 | PTKc_Frk_like |
| cd14023 | 165-342 | PK_TRB1 |
| cd06639 | 88-282 | STKc_myosinIIIB_N |
| cd07876 | 188-356 | STKc_JNK2 |
| cd05112 | 80-275 | PTKc_Itk |
| cd14063 | 81-293 | PK_KSR |
| cd07837 | 83-343 | STKc_CdkB_plant |
| cd05114 | 81-294 | PTKc_Tec_Rlk |
| cd05075 | 84-282 | PTKc_Axl |
| cd05113 | 80-296 | PTKc_Btk_Bmx |
| cd05067 | 80-276 | PTKc_Lck_Blk |
| cd14049 | 87-323 | STKc_EIF2AK1_HRI |
| cd13991 | 88-282 | STKc_NIK |
| cd14154 | 88-309 | STKc_LIMK |
| cd14148 | 87-283 | STKc_MLK2 |
| cd14221 | 88-276 | STKc_LIMK1 |
| cd05111 | 81-284 | PTK_HER3 |
| cd06617 | 189-343 | PKc_MKK3_6 |
| cd07865 | 83-342 | STKc_CDK9 |
| cd14017 | 82-283 | STKc_TTBK |
| cd05081 | 82-275 | PTKc_Jak3_rpt2 |
| cd14000 | 87-324 | STKc_LRRK |
| cd14225 | 87-287 | PKc_DYRK4 |
| cd14150 | 86-282 | STKc_A-Raf |
| cd14222 | 88-276 | STKc_LIMK2 |
| cd14031 | 82-346 | STKc_WNK3 |
| cd05116 | 88-326 | PTKc_Syk |
| cd14012 | 126-330 | PK_eIF2AK_GCN2_rpt1 |
| cd07867 | 88-287 | STKc_CDC2L6 |
| cd14224 | 82-287 | PKc_DYRK2_3 |
| cd07874 | 86-356 | STKc_JNK3 |
| cd05066 | 83-277 | PTKc_EphR_A |
| cd05034 | 86-276 | PTKc_Src_like |
| cd05085 | 85-282 | PTKc_Fer |
| cd14664 | 88-282 | STK_BAK1_like |
| cd14054 | 87-287 | STKc_BMPR2_AMHR2 |
| cd13968 | 88-225 | PKc_like |
| cd05098 | 84-275 | PTKc_FGFR1 |
| cd05083 | 84-282 | PTKc_Chk |
| cd05148 | 80-294 | PTKc_Srm_Brk |
| cd05033 | 86-277 | PTKc_EphR |
| cd05101 | 80-275 | PTKc_FGFR2 |
| cd05089 | 80-277 | PTKc_Tie1 |
| cd14147 | 127-284 | STKc_MLK3 |
| cd14156 | 88-324 | PKc_LIMK_like_unk |
| cd05040 | 86-294 | PTKc_Ack_like |
| cd05100 | 84-275 | PTKc_FGFR3 |
| cd13998 | 154-276 | STKc_TGFbR-like |
| cd05080 | 82-276 | PTKc_Tyk2_rpt2 |
| cd14053 | 86-331 | STKc_ACVR2 |
| cd14151 | 188-282 | STKc_B-Raf |
| cd14062 | 188-283 | STKc_Raf |
| cd05099 | 80-275 | PTKc_FGFR4 |
| cd05052 | 129-282 | PTKc_Abl |
| cd14030 | 82-346 | STKc_WNK1 |
| cd08216 | 84-282 | PK_STRAD |
| cd05109 | 86-282 | PTKc_HER2 |
| cd05110 | 81-276 | PTKc_HER4 |
| cd07868 | 88-287 | STKc_CDK8 |
| cd05092 | 88-275 | PTKc_TrkA |
| cd14204 | 85-282 | PTKc_Mer |
| cd05048 | 80-282 | PTKc_Ror |
| cd05055 | 80-324 | PTKc_PDGFR |
| cd05049 | 80-275 | PTKc_Trk |
| cd14032 | 82-294 | STKc_WNK2_like |
| cd05084 | 85-282 | PTKc_Fes |
| cd05115 | 88-291 | PTKc_Zap-70 |
| cd13976 | 165-342 | PK_TRB |
| cd05047 | 87-282 | PTKc_Tie |
| cd05091 | 83-282 | PTKc_Ror2 |
| cd05065 | 83-277 | PTKc_EphR_B |
| cd05073 | 80-282 | PTKc_Hck |
| cd05093 | 88-275 | PTKc_TrkB |
| cd14025 | 88-296 | STKc_RIP4_like |
| cd05058 | 86-290 | PTKc_Met_Ron |
| cd14153 | 83-292 | PK_KSR2 |
| cd05050 | 88-282 | PTKc_Musk |
| cd13975 | 182-278 | PKc_Dusty |
| cd05032 | 80-280 | PTKc_InsR_like |
| cd05063 | 86-277 | PTKc_EphR_A2 |
| cd13981 | 86-306 | STKc_Bub1_BubR1 |
| cd14214 | 88-295 | PKc_CLK3 |
| cd14203 | 86-294 | PTKc_Src_Fyn_like |
| cd14064 | 88-282 | PKc_TNNI3K |
| cd05053 | 80-280 | PTKc_FGFR |
| cd14142 | 150-282 | STKc_ACVR1_ALK1 |
| cd14152 | 83-292 | STKc_KSR1 |
| cd05056 | 80-282 | PTKc_FAK |
| cd14024 | 165-325 | PK_TRB3 |
| cd14149 | 188-325 | STKc_C-Raf |
| cd05094 | 81-290 | PTKc_TrkC |
| cd05095 | 84-274 | PTKc_DDR2 |
| cd05088 | 81-277 | PTKc_Tie2 |
| cd05071 | 80-275 | PTKc_Src |
| cd14140 | 154-277 | STKc_ACVR2b |
| cd14126 | 81-280 | STKc_CK1_gamma |
| cd14026 | 88-282 | STKc_RIP2 |
| cd14001 | 84-281 | PKc_TOPK |
| cd14055 | 160-277 | STKc_TGFbR2_like |
| cd13977 | 155-276 | STKc_PDIK1L |
| cd05069 | 80-276 | PTKc_Yes |
| cd14056 | 161-274 | STKc_TGFbR_I |
| cd14068 | 87-278 | STKc_LRRK2 |
| cd05070 | 80-294 | PTKc_Fyn |
| cd05041 | 88-283 | PTKc_Fes_like |
| cd13980 | 183-329 | STKc_Vps15 |
| cd05090 | 129-306 | PTKc_Ror1 |
| cd14155 | 88-280 | PKc_TESK |
| cd05102 | 185-282 | PTKc_VEGFR3 |
| cd05097 | 80-275 | PTKc_DDR_like |
| TIGR03724 | 164-229 | arch_bud32 |
| smart00220 | 82-342 | S_TKc |
| pfam00069 | 82-342 | Pkinase |
| PTZ00263 | 81-371 | PTZ00263 |
| PTZ00426 | 80-350 | PTZ00426 |
| COG0515 | 81-358 | SPS1 |
| PHA03390 | 90-342 | pk1 |
| PTZ00266 | 81-337 | PTZ00266 |
| smart00221 | 83-275 | STYKc |
| PTZ00036 | 82-345 | PTZ00036 |
| smart00219 | 83-275 | TyrKc |
| PTZ00267 | 121-324 | PTZ00267 |
| pfam07714 | 82-269 | Pkinase_Tyr |
| PLN00034 | 13-287 | PLN00034 |
| PRK13184 | 86-283 | pknD |
| PTZ00283 | 86-324 | PTZ00283 |
| PTZ00024 | 80-329 | PTZ00024 |
| PHA03210 | 111-277 | PHA03210 |
| PHA03207 | 129-277 | PHA03207 |
| TIGR03903 | 104-280 | TOMM_kin_cyc |
| PLN00009 | 88-325 | PLN00009 |
| PTZ00284 | 82-278 | PTZ00284 |
| PHA03211 | 188-274 | PHA03211 |
| PHA03212 | 118-278 | PHA03212 |
| PHA03209 | 188-305 | PHA03209 |
| COG4248 | 185-278 | YegI |
| TIGR01982 | 200-244 | UbiB |
Ontology Information
| HPRD ID | 359 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| O15530 | DB00482 | Celecoxib | SmallMoleculeDrug |