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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ACSL5 51703 acyl-CoA synthetase long-chain family member 5  10ACS5, ACS2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24222123   2013Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 53

Stage : -

real time RT-PCRDown-regulation-Six genes were down-regulated: destrin (DSTN), mesoderm induction early response 1, family member 3 (MIER3), acyl-CoA synthetase long-chain family member 5 (ACSL5), mitogen-activated protein kinase 1/ERK (MAPK1), claudin 23 (CLDN23) and solute carrier family 26 (sulfate transporter), member 2 (SLC26A2).

24770931   2014Cell line : CaCo2

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR, Western blotting, short-interfering-RNA-mediated gene silencing Down-regulation-ACSL5-induced mitochondrial mortalin expression is assumed to be a stress response to ACSL5-related changes in lipid metabolism and is regulated by the TP53 status.


Gene Details



NC_000010.10 (114133916..114188138)

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Gene Type protein coding
Gene Family Acyl-CoA synthetase family
Description The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 10
Location 10q25.1-q2
Start 114133916  
End 114188138  
Strand +  
Gene Sequence

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Length 54223  
OMIM ID 605677   
HGNC ID HGNC:16526   
Unigene ID Hs.11638   
Ensembl ID ENSG00000197142   
PharmGKB ID PA27969   

mRNA Information


mRNA ID ?NM_016234.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS7572.1



Protein Information


      
Protein IDNP_057318.2
Protein Nameacyl-CoA synthetase long-chain family member 5
Molecular Wt. (Da)0
Protein Sequence

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Length 683  
Uniprot IDP82987
Ensembl Protein ID ENSP00000286744  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation32

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                          
Pathway Name Pathway ID
Adipocytokine signaling pathway hsa04920
Fatty acid biosynthesis hsa00061
Fatty acid degradation hsa00071
Fatty acid metabolism hsa01212
Metabolic pathways hsa01100
Peroxisome hsa04146
PPAR signaling pathway hsa03320


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd05927101-678  LC-FACS_euk
cl17068101-678  AFD_class_I superfamily
cd05907102-666  VL_LC_FACS_like
cd05932101-670  LC_FACS_bac
cd0593398-678  ACSBG_like
cd05936106-544  FC-FACS_FadD_like
cd05917252-610  FACL_like_2
cd05911106-561  Firefly_Luc_like
cd04433254-588  AFD_class_I
cd05941104-588  MCS
cd05909106-626  AAS_C
cd05904106-561  4CL
cd05929253-560  BACL_like
cd05903106-598  CHC_CoA_lg
cd05926252-591  FACL_fum10p_like
cd05934104-609  FACL_DitJ_like
cd05935106-575  LC_FACS_like
cd05914106-663  FACL_like_3
cd05922252-591  FACL_like_6
cd1211996-561  ttLC_FACS_AlkK_like
cd05912253-573  OSB_CoA_lg
cd12118104-561  ttLC_FACS_AEE21_like
cd05944252-570  FACL_like_4
cd0592075-560  23DHB-AMP_lg
cd05945106-590  DltA
cd12117106-592  A_NRPS_Srf_like
cd05908252-561  A_NRPS_MycA_like
cd12114106-600  A_NRPS_TlmIV_like
cd05918106-589  A_NRPS_SidN3_like
cd05930104-598  A_NRPS
cd05931106-570  FAAL
cd05971107-668  MACS_like_3
cd0592197-656  FCS
cd0590672-629  A_NRPS_TubE_like
cd05972109-560  MACS_like
cd05970109-593  MACS_AAE_MA_like
cd12116104-598  A_NRPS_Ta1_like
cd05919106-591  BCL_like
cd0595978-611  BCL_4HBCL
cd05973106-609  MACS_like_2
cd12115106-600  A_NRPS_Sfm_like
cd05923101-588  CBAL
cd05910250-601  FACL_like_1
cd05940104-591  FATP_FACS
cd05974397-561  MACS_like_1
cd05958104-575  ABCL
cd05915235-586  ttLC_FACS_like
cd05969106-575  MACS_like_4
cd05928412-560  MACS_euk
cd05968104-275  AACS_like
cd05938246-310  hsFATP2a_ACSVL_like
cd05924250-559  FACL_like_5
cd05939104-309  hsFATP4_like
cd05967104-270  PrpE
cd05966177-312  ACS
cd05943204-275  AACS
PLN0273671-681  PLN02736
PLN0243072-679  PLN02430
COG102296-679  FAA1
PLN02861102-678  PLN02861
PLN0261475-683  PLN02614
PLN0238747-679  PLN02387
PTZ00216104-679  PTZ00216
pfam0050197-548  AMP-binding
COG031876-588  CaiC
PRK07656106-545  PRK07656
PRK06187107-561  PRK06187
PTZ00342218-680  PTZ00342
TIGR01923108-573  menE
PRK08751235-571  PRK08751
PRK05677235-570  PRK05677
PRK05605232-544  PRK05605
COG0365106-560  Acs
PRK0608796-561  PRK06087
PRK1258375-575  PRK12583
PRK07529131-542  PRK07529
PRK08974251-585  PRK08974
PRK12492231-561  PRK12492
PRK07514232-589  PRK07514
PLN02330254-561  PLN02330
PRK06839106-575  PRK06839
PRK07059246-561  PRK07059
PRK0831599-560  PRK08315
TIGR01733107-559  AA-adenyl-dom
PRK08633158-540  PRK08633
PLN02246207-559  PLN02246
PRK09088125-559  PRK09088
PRK06188135-545  PRK06188
PRK06710248-583  PRK06710
COG1020102-559  EntF
PTZ0029774-678  PTZ00297
PRK0831485-561  PRK08314
PRK0778698-561  PRK07786
PRK07787250-595  PRK07787
TIGR03098104-592  ligase_PEP_1
PLN02574178-561  PLN02574
PRK13295250-588  PRK13295
PRK0818097-656  PRK08180
PRK08316104-562  PRK08316
TIGR0320875-598  cyc_hxne_CoA_lg
PRK03640106-577  PRK03640
TIGR0320592-575  pimA
PRK05852247-595  PRK05852
PRK08008248-561  caiC
PLN03102106-573  PLN03102
PRK12467106-589  PRK12467
PRK07768177-559  PRK07768
PRK08162104-569  PRK08162
PRK05620106-575  PRK05620
PLN02860204-666  PLN02860
PRK06814106-567  PRK06814
PRK08043248-580  PRK08043
PRK06178106-569  PRK06178
PRK06334252-561  PRK06334
PLN02479103-573  PLN02479
PRK12316106-601  PRK12316
PRK07867135-592  PRK07867
PRK09029247-573  PRK09029
PRK06164104-559  PRK06164
PRK07470139-559  PRK07470
PRK06145235-587  PRK06145
PRK1258292-656  PRK12582
PRK1246771-594  PRK12467
TIGR01734106-568  D-ala-DACP-lig
PRK06155104-559  PRK06155
PRK07008166-561  PRK07008
PRK07798104-598  PRK07798
PRK12406249-559  PRK12406
PRK06018107-561  PRK06018
PRK09192249-559  PRK09192
PRK12316104-609  PRK12316
TIGR02262102-609  benz_CoA_lig
PRK05851249-561  PRK05851
PRK12316106-589  PRK12316
PRK13390106-611  PRK13390
PRK09274247-588  PRK09274
PRK1231639-589  PRK12316
PRK13391413-600  PRK13391
PRK07788106-540  PRK07788
COG1021245-560  EntE
PRK05691106-570  PRK05691
PRK0481398-588  PRK04813
PRK08276106-600  PRK08276
TIGR02275204-560  DHB_AMP_lig
PRK04319135-275  PRK04319
PRK12467104-589  PRK12467
PRK13382106-592  PRK13382
PRK07824250-598  PRK07824
PRK05857135-600  PRK05857
PRK10946414-560  entE
PRK1338877-589  PRK13388
PRK10252246-598  entF
PRK07638402-575  PRK07638
PRK05691252-540  PRK05691
PRK05850260-309  PRK05850
PRK07769246-544  PRK07769
PRK05691106-559  PRK05691
PRK08279106-309  PRK08279
PRK07445443-575  PRK07445
PLN0265496-460  PLN02654
COG1541219-450  PaaK


Ontology Information


   
HPRD ID17630
Molecular ClassEnzyme: Ligase
Molecular FunctionHydrolase activity (GO:0016787)
Biological ProcessCell proliferation (GO:0008283); Cell differentiation (GO:0030154)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO