Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MSRB1 | 51734 | methionine sulfoxide reductase B1 | 16 | SelR, SepR, SelX |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22615972 | 2012 | Cell line : - Source : - Sample Type : Population-based case-control studies No. of Sample : Colon cancer 1555 cases, 1956 controls and rectal 754 cases, 959 controls Stage : - | Meta analysis | Polymorhpism | - | Findings support an association between selenoprotein genes and colon and rectal cancer development and survival after diagnosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase (Msr) protein family which includes repair enzymes that reduce oxidized methionine residues in proteins. The protein encoded by this gene is expressed in a variety of adult and fetal tissues and localizes to the cell nucleus and cytosol. [provided by RefSeq, Mar 2012] |
| Chromosome | 16 |
| Location | 16p13.3 |
| Start | 1988234 |
| End | 1993294 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5061 |
| OMIM ID | 606216 |
| HGNC ID | HGNC:14133 |
| Unigene ID | Hs.655346 |
| Ensembl ID | ENSG00000198736 |
| PharmGKB ID | PA37848 |
Protein Information
| Protein ID | NP_057416.1 |
|---|---|
| Protein Name | methionine sulfoxide reductase B1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 116 |
| Uniprot ID | Q9HCY8 |
| Ensembl Protein ID | ENSP00000340463 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| PRK00222 | 7-116 | PRK00222 |
| cl15841 | 7-116 | SelR superfamily |
| COG0229 | 7-108 | MsrB |
| pfam01641 | 7-106 | SelR |
| TIGR00357 | 14-106 | TIGR00357 |
| PRK05508 | 7-108 | PRK05508 |
| PRK05550 | 7-114 | PRK05550 |
| PRK14018 | 12-108 | PRK14018 |
| COG1594 | 19-76 | RPB9 |
Ontology Information
| HPRD ID | 5731 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9NZV6 | DB00134 | L-Methionine | SmallMoleculeDrug |