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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RSF1 51773 remodeling and spacing factor 1  11XAP8, RSF-1, p325 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22528946   2012Cell line : HT29, HCT116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Immunohystochemistry,Western BlottingUp-regulation-Rsf-1 is overexpressed in colon cancers and contributes to malignant cell growth by cyclin E and phospho-Rb modulation, which makes Rsf-1 a candidate therapeutic target in colon cancer.


Gene Details



NC_000011.9 (77371047..77531915, complement)

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Gene Type protein coding
Gene Family Zinc fingers, PHD-type
Description This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]  
Chromosome 11
Location 11q14.1
Start 77371047  
End 77531915  
Strand -  
Gene Sequence

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Length 160869  
OMIM ID 608522   
HGNC ID HGNC:18118   
Unigene ID Hs.420229   
Ensembl ID ENSG00000048649   
PharmGKB ID PA29210   

mRNA Information


mRNA ID ?NM_016578.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS8253.1



Protein Information


      
Protein IDNP_057662.3
Protein Nameremodeling and spacing factor 1
Molecular Wt. (Da)0
Protein Sequence

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Length 1441  
Uniprot IDQ9NR09
Ensembl Protein ID ENSP00000393596  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation524;-
SPhosphorylation1325;-
SPhosphorylation1226;-
SPhosphorylation1221;-
SPhosphorylation1223;-
SPhosphorylation778;-
SPhosphorylation604;-
SPhosphorylation1345;-
SPhosphorylation1184;-
SPhosphorylation1187;-
SPhosphorylation1189;-
TPhosphorylation1202;-
YPhosphorylation1171;-
SPhosphorylation1172;-
SPhosphorylation748;-
YPhosphorylation1341;-
SPhosphorylation1096;-
SPhosphorylation1105;-
SPhosphorylation1098;-
SPhosphorylation782;-
SPhosphorylation632;-
SPhosphorylation617;-
SPhosphorylation622;-
SPhosphorylation1375;-
SPhosphorylation1359;-
SPhosphorylation392
SPhosphorylation397
TPhosphorylation628
SPhosphorylation629
SPhosphorylation1277
TPhosphorylation1278
YPhosphorylation1281
SPhosphorylation1282
TPhosphorylation1305
SPhosphorylation1364
TPhosphorylation1371
TPhosphorylation1388
KAcetylation1050
KAcetylation1339
KAcetylation1061
SPhosphorylation1370
SPhosphorylation1135
SPhosphorylation1139
TPhosphorylation1141
SPhosphorylation473
SPhosphorylation540
YPhosphorylation1363
SPhosphorylation1310
TPhosphorylation506
SPhosphorylation218
SPhosphorylation227
TPhosphorylation432
SPhosphorylation447
TPhosphorylation539
SPhosphorylation882
SPhosphorylation1252
TPhosphorylation594
TPhosphorylation736
SPhosphorylation741

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4790NFKB11238NP_003989.2in vitro;in vivo15242768   
8467SMARCA54538NP_003592.2in vivo12972596   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd15543893-938  PHD_RSF1
cl22851893-938  PHD_SF superfamily
cd15519894-938  PHD1_Lid2p_like
cd15627894-938  PHD_BAZ1A
cd15515894-938  PHD1_KDM5A_like
cd15545894-938  PHD_BAZ2A_like
cd15525894-938  PHD_UHRF1_2
cd15536894-938  PHD_PHRF1
cd15544894-938  PHD_BAZ1A_like
cd15532894-938  PHD2_CHD_II
pfam00628894-941  PHD
cd15629894-938  PHD_BAZ2A
cd15605894-938  PHD1_Lid_like
smart00249894-938  PHD
cd15529894-938  PHD2_PHF10
cd15617894-938  PHD_UHRF2
cd15603894-938  PHD1_KDM5B
cd15616894-938  PHD_UHRF1
cd15630894-938  PHD_BAZ2B
cd15513894-938  PHD5_KMT2C_like
cd15602894-938  PHD1_KDM5A
cd15604894-938  PHD1_KDM5C_5D
cd15527894-938  PHD2_KAT6A_6B
cd15628894-938  PHD_BAZ1B
cd15489894-938  PHD_SF
cd15595894-938  PHD2_KMT2D
cd15594894-938  PHD2_KMT2C
cd15523894-938  PHD_PHF21A
cd15530894-938  PHD2_d4
cd15539906-938  PHD1_AIRE
cd15504894-938  PHD_PRHA_like
cd15510894-938  PHD2_KMT2C_like
cd15502894-938  PHD_Phf1p_Phf2p_like
cd15535894-938  PHD1_Rco1
cd15578894-940  PHD1_MTF2
cd15499894-939  PHD1_MTF2_PHF19_like
cd15531906-938  PHD1_CHD_II
cd15559906-938  PHD1_BPTF
cd15562894-938  PHD2_PHF14
cd15524909-938  PHD_PHF21B
cd15492901-938  PHD_BRPF_JADE_like
cd04718915-968  BAH_plant_2
cl02608915-968  BAH superfamily
cd15533894-938  PHD1_PHF12
cd15534893-936  PHD2_PHF12_Rco1
pfam1561298-148  WHIM1
cl2141198-148  WHIM1 superfamily
cd15623894-938  PHD_TIF1beta
cd15509893-938  PHD1_KMT2C_like
cd15497894-938  PHD1_Snt2p_like
pfam15613150-182  WHIM2
cl21412150-182  WHIM2 superfamily
cd15517893-938  PHD_TCF19_like
cd15538894-938  PHD_PRKCBP1
pfam027241097-1170  CDC45
cl036781097-1170  CDC45 superfamily
cd15567906-938  PHD4_NSD
cd15625906-940  PHD_TIF1delta
cd15622906-938  PHD_TIF1alpha
cd15676887-938  PHD_BRPF1
cd15563894-938  PHD3_PHF14
cd15657906-939  PHD4_NSD2
cd15573893-938  PHD_JADE
cd15624906-939  PHD_TIF1gamma
cd15677891-938  PHD_BRPF2
cd16039894-938  PHD_SPP1
cd15522894-938  PHD_TAF3
cd15572891-938  PHD_BRPF
cd15656906-938  PHD4_NSD1
cd15541907-938  PHD_TIF1_like
PTZ001081149-1352  PTZ00108


Ontology Information


   
HPRD ID10660
Molecular ClassTranscription regulatory protein
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO