Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PGAM1 | 5223 | Phosphoglycerate mutase 1 (brain) | 10 | PGAMA; PGAM-B |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20812987 | 2010 | Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : - No. of Sample : - Stage : - | 2-D Gel electrophoresis, and mass spectrometry,Western blotting , Immunohistochemistry | Up-regulation | - | This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis In total, 150 patients were involved in the study. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Phosphoglyceric acid mutase (EC 2.7.5.3) is widely distributed in mammalian tissues where it catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway (summary by Chen et al., 1974 [PubMed 4811757]).[supplied by OMIM, Nov 2010] |
| Chromosome | 10 |
| Location | 10q25.3 |
| Start | 97426270 |
| End | 97433441 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7172 |
| OMIM ID | 172250 |
| HGNC ID | HGNC:8888 |
| Unigene ID | Hs.632918 |
| Ensembl ID | ENSG00000171314 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002629.2 |
|---|---|
| Exon | join(1..177,4110..4384,4686..4866,6086..7172) | mRNA Sequence | Download Select all |
| Length | 1762 |
CDS Information
| Location | join(39..177,4110..4384,4686..4866,6086..6255) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS7458.1 |
Protein Information
| Protein ID | NP_002620.1 |
|---|---|
| Protein Name | Phosphoglycerate mutase 1 (brain) |
| Molecular Wt. (Da) | 28673 |
| Protein Sequence | Download Select all |
| Length | 254 |
| Uniprot ID | P02452 |
| Ensembl Protein ID | ENSP00000225964 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 26;- |
| Y | Phosphorylation | 92;- |
| Y | Phosphorylation | 119;- |
| Y | Phosphorylation | 133;- |
| K | Acetylation | 113 |
| K | Acetylation | 5 |
| K | Acetylation | 100 |
| K | Acetylation | 176 |
| S | Phosphorylation | 14 |
| S | Phosphorylation | 118 |
| S | Phosphorylation | 31 |
| T | Phosphorylation | 146 |
Enzyme Information
| EC | 5.4.2.1 |
|---|---|
| Name | phosphoglycerate mutase phosphoglycerate phosphomutase phosphoglyceromutase glycerate phosphomutase (diphosphoglycerate cofactor) monophosphoglycerate mutase monophosphoglyceromutase diphosphoglycomutase diphosphoglycerate mutase bisphosphoglyceromutase GriP mutase MPGM PGA mutase PGAM-i PGAM PGAM-d PGM |
| Class | Isomerases; Intramolecular transferases; Phosphotransferases (phosphomutases) |
| Sysname | D-phosphoglycerate 2,3-phosphomutase |
| Substrate | 2-phospho-D-glycerate |
| Product | 3-phospho-D-glycerate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 8502 | PKP4 | 5043 | NP_003619.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Biosynthesis of amino acids | hsa01230 |
| Carbon metabolism | hsa01200 |
| Central carbon metabolism in cancer | hsa05230 |
| Glucagon signaling pathway | hsa04922 |
| Glycine, serine and threonine metabolism | hsa00260 |
| Glycolysis / Gluconeogenesis | hsa00010 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07067 | 5-228 | HP_PGM_like |
| cl11399 | 5-228 | HP superfamily |
| PRK14115 | 4-253 | gpmA |
| TIGR01258 | 5-251 | pgm_1 |
| PTZ00123 | 16-253 | PTZ00123 |
| COG0588 | 5-235 | GpmA |
| PRK14120 | 1-251 | gpmA |
| PRK14118 | 5-228 | gpmA |
| PRK14117 | 5-228 | gpmA |
| PRK14116 | 5-225 | gpmA |
| PRK14119 | 5-227 | gpmA |
| PRK01295 | 6-221 | PRK01295 |
| PRK01112 | 5-222 | PRK01112 |
| smart00855 | 5-191 | PGAM |
| cd07040 | 5-226 | HP |
| pfam00300 | 5-193 | His_Phos_1 |
| COG0406 | 5-223 | PhoE |
| TIGR03162 | 6-213 | ribazole_cobC |
| PRK15004 | May-93 | PRK15004 |
| PRK13462 | 4-102 | PRK13462 |
| COG2062 | May-75 | SixA |
| PRK03482 | Aug-95 | PRK03482 |
| TIGR03848 | Jun-97 | MSMEG_4193 |
| PRK07238 | 6-109 | PRK07238 |
Ontology Information
| HPRD ID | 355 |
|---|---|
| Molecular Class | Enzyme: Mutase |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.