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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16251413 | 2005 | Cell line : - Source : Charles River Breeding Farms (Montreal, PQ, Canada). Sample Type : - No. of Sample : Male, Wistar rats Stage : - | Western Blotting,Immunohistochemistry | Up-regulation | - | PGD2 may therefore represent a rational target for therapies directed at reducing the incidence of colitis-associated colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015] |
| Chromosome | 1 |
| Location | 1p36.22 |
| Start | 10458884 |
| End | 10480565 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 21682 |
| OMIM ID | 172200 |
| HGNC ID | HGNC:8891 |
| Unigene ID | Hs.464071 |
| Ensembl ID | ENSG00000142657 |
| PharmGKB ID | PA33229 |
mRNA Information
| mRNA ID | NM_002631.3 |
|---|---|
| Exon | join(1..134,638..713,1402..1581,4080..4145,5170..5288, 9080..9149,12427..12561,14071..14260,17996..18126, 18385..18518,19835..19934,20426..20548,20639..21520) | mRNA Sequence | Download Select all |
| Length | 2353 |
Protein Information
| Protein ID | NP_002622.2 |
|---|---|
| Protein Name | phosphogluconate dehydrogenase |
| Molecular Wt. (Da) | 44484 |
| Protein Sequence | Download Select all |
| Length | 483 |
| Uniprot ID | O75362 |
| Ensembl Protein ID | ENSP00000304308 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 59 |
| K | Acetylation | 309 |
| K | Acetylation | 154 |
| K | Acetylation | 76 |
| K | Acetylation | 38 |
| T | Phosphorylation | 470 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Carbon metabolism | hsa01200 |
| Glutathione metabolism | hsa00480 |
| Metabolic pathways | hsa01100 |
| Pentose phosphate pathway | hsa00030 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00393 | 180-470 | 6PGD |
| cl02856 | 180-470 | 6PGD superfamily |
| pfam03446 | 4-164 | NAD_binding_2 |
| cl21454 | 4-164 | NADB_Rossmann superfamily |
| PRK09287 | 14-473 | PRK09287 |
| COG0362 | 1-475 | Gnd |
| TIGR00873 | 5-471 | gnd |
| PTZ00142 | 3-470 | PTZ00142 |
| PLN02350 | 1-470 | PLN02350 |
| PRK09599 | 5-288 | PRK09599 |
| COG1023 | 6-296 | YqeC |
| PRK12490 | 6-296 | PRK12490 |
| TIGR00872 | 6-295 | gnd_rel |
| COG2084 | 6-206 | MmsB |
| PRK11559 | 5-185 | garR |
| TIGR01505 | 6-201 | tartro_sem_red |
Ontology Information
| HPRD ID | 3120 |
|---|---|
| Molecular Class | Enzyme: Dehydrogenase |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P52209 | DB00563 | Methotrexate | SmallMoleculeDrug |
| P52209 | DB00695 | Furosemide | SmallMoleculeDrug |
| P52209 | DB00814 | Meloxicam | SmallMoleculeDrug |
| P52209 | DB00867 | Ritodrine | SmallMoleculeDrug |
| P52209 | DB00789 | Gadopentetate dimeglumine | SmallMoleculeDrug |
| P52209 | DB00851 | Dacarbazine | SmallMoleculeDrug |
| P52209 | DB00920 | Ketotifen | SmallMoleculeDrug |