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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20596663 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Two-dimensional electrophoresis (2-DE) ,MALDI-TOF/TOF MS,immunohistochemistry assay,tissue microassays (TMA),Western blot . | Up-regulation | 2 Fold | Overexpression of PHB might be associated with the transformation process from adenoma to CRC. Further, it is a potential diagnostic and differentiation biomarker of CRC in the clinic. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| Chromosome | 17 |
| Location | 17q21 |
| Start | 47481410 |
| End | 47492267 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 10858 |
| OMIM ID | 176705 |
| HGNC ID | HGNC:8912 |
| Unigene ID | Hs.514303 |
| Ensembl ID | ENSG00000167085 |
| PharmGKB ID | PA33251 |
mRNA Information
| mRNA ID | NM_001281497.1 |
|---|---|
| Exon | join(1..71,1615..1729,3067..3228,5433..5575,5748..5771, 9864..10858) | mRNA Sequence | Download Select all |
| Length | 1520 |
Protein Information
| Protein ID | NP_001268426.1 |
|---|---|
| Protein Name | prohibitin |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 155 |
| Uniprot ID | P27930 |
| Ensembl Protein ID | ENSP00000330959 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 252;- |
| S | Phosphorylation | 254;- |
| S | Phosphorylation | 265 |
| K | Acetylation | 202 |
| Y | Phosphorylation | 249 |
| T | Phosphorylation | 80 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 302 | ANXA2 | 1061 | NP_001002858.1 | in vitro;in vivo;yeast 2-hybrid | 12628297 |
| 5894 | RAF1 | 1265 | NP_002871.1 | in vitro;in vivo | 10523633 |
| 5933 | RBL1 | 312 | NP_002886.2 | in vitro;in vivo | 10376528 |
| 7514 | XPO1 | 3975 | NP_003391.1 | in vivo | 16319068 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03401 | 27-221 | SPFH_prohibitin |
| cl19107 | 27-221 | SPFH_like superfamily |
| smart00244 | 26-187 | PHB |
| pfam01145 | 28-207 | Band_7 |
| cd03405 | 26-227 | SPFH_HflC |
| cd13435 | 51-248 | SPFH_SLP-4 |
| cd02106 | 74-177 | SPFH_like |
| cd13438 | 30-248 | SPFH_eoslipins_u2 |
| cd08826 | 59-248 | SPFH_eoslipins_u1 |
| cd13437 | 28-248 | SPFH_alloslipin |
| cd03407 | 36-241 | SPFH_like_u4 |
| cd03404 | 13-231 | SPFH_HflK |
| cd03403 | 51-248 | SPFH_stomatin |
| PRK11029 | 181-245 | PRK11029 |
| cd13775 | 112-259 | SPFH_eoslipins_u3 |
| COG0330 | 13-231 | HflC |
| TIGR01932 | 53-247 | hflC |
| COG2268 | 46-223 | YqiK |
Ontology Information
| HPRD ID | 3427 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.