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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 14631119 | 2003 | Cell line : 10 colon tumor cell lines Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 8 Stage : - | RT-PCR | Down-regulation | - | Differential regulation of PIGR mRNA stability may contribute to its downregulation in colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / V-set domain containing |
| Description | This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009] |
| Chromosome | 1 |
| Location | 1q31-q41 |
| Start | 207101867 |
| End | 207119814 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 17948 |
| OMIM ID | 173880 |
| HGNC ID | HGNC:8968 |
| Unigene ID | Hs.497589 |
| Ensembl ID | ENSG00000162896 |
| PharmGKB ID | PA33300 |
mRNA Information
| mRNA ID | ?NM_002644.3 |
|---|---|
| Exon | join(1..131,5883..5978,7004..7348,8716..9372,10649..10981, 11721..12047,13301..13481,13890..14011,14665..14796, 14912..14970,16054..17945) | mRNA Sequence | Download Select all |
| Length | 4295 |
Protein Information
| Protein ID | NP_002635.2 |
|---|---|
| Protein Name | polymeric immunoglobulin receptor |
| Molecular Wt. (Da) | 170552 |
| Protein Sequence | Download Select all |
| Length | 764 |
| Uniprot ID | P61073 |
| Ensembl Protein ID | ENSP00000241393 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 135 |
| N | Glycosylation | 186 |
| N | Glycosylation | 421 |
| N | Glycosylation | 469 |
| N | Glycosylation | 499 |
| S | Phosphorylation | 673 |
| S | Phosphorylation | 735 |
| N | Glycosylation | 83 |
| N | Glycosylation | 90 |
| S | Phosphorylation | 274 |
| Y | Phosphorylation | 373 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 973 | CD79A | 203 | NP_001774.1 | in vivo | 798 933 319 403 461 000 000 000 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Intestinal immune network for IgA production | hsa04672 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05716 | 358-457 | Ig_pIgR |
| cl11960 | 358-457 | Ig superfamily |
| cd05716 | 469-560 | Ig_pIgR |
| cl11960 | 469-560 | Ig superfamily |
| cd05716 | 27-126 | Ig_pIgR |
| cl11960 | 27-126 | Ig superfamily |
| cd05716 | 244-336 | Ig_pIgR |
| cl11960 | 244-336 | Ig superfamily |
| cd05716 | 139-226 | Ig_pIgR |
| cl11960 | 139-226 | Ig superfamily |
| cd05878 | 33-128 | Ig_Aggrecan_like |
| cd00099 | 145-231 | IgV |
| cd05714 | 364-441 | Ig_CSPGs_LP |
| cd04983 | 127-230 | IgV_TCR_alpha_like |
| cd00099 | 32-113 | IgV |
| cd05878 | 364-441 | Ig_Aggrecan_like |
| cd05877 | 280-325 | Ig_LP_like |
| cd07706 | 136-220 | IgV_TCR_delta |
| cd05714 | 33-128 | Ig_CSPGs_LP |
| cd05877 | 187-253 | Ig_LP_like |
| smart00406 | 35-110 | IGv |
| cd05775 | 183-238 | Ig_SLAM-CD84_like_N |
| cd05902 | 365-441 | Ig_Neurocan |
| cd00096 | 484-550 | Ig |
| cd05714 | 187-221 | Ig_CSPGs_LP |
| smart00410 | 467-560 | IG_like |
| smart00410 | 138-237 | IG_like |
| smart00410 | 25-127 | IG_like |
| smart00410 | 356-457 | IG_like |
| smart00409 | 467-560 | IG |
| smart00409 | 138-237 | IG |
| smart00409 | 25-127 | IG |
| smart00409 | 356-457 | IG |
| smart00410 | 267-337 | IG_like |
| smart00409 | 267-337 | IG |
Ontology Information
| HPRD ID | 3950 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.