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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PIK3C2G 5288 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma  12- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25785104   2015Cell line : -

Source : Ruijin Hospital and The Tenth People's Hospital were recruited.

Sample Type : CRC tumor and normal tissue

No. of Sample : 142

Stage : TNM Stage III

DNA extraction,real time RT- PCR and copy number analysisDown-regulation--


Gene Details



NC_000012.11 (18395912..18801352)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]  
Chromosome 12
Location 12p12
Start 18395912  
End 18801352  
Strand +  
Gene Sequence

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Length 405441  
OMIM ID 609001   
HGNC ID HGNC:8973   
Unigene ID Hs.22500   
Ensembl ID ENSG00000139144   
PharmGKB ID PA33306   

mRNA Information


mRNA ID ?NM_001288772.1
Exon join(1..84,39040..39795,43883..43965,47891..48048, 50937..51051,70998..71100,77998..78068,82071..82134, 95462..95584,100363..100396,103677..103872,119800..119922, 128216..128347,138802..138916,148158..148288, 156695..156883,177977..178070,180981..181075, 245485..245665,248487..248594,253098..253190, 254655..254784,260317..260453,262328..262497, 295192..295348,303359..303468,319739..319928, 320413..320534,323985..324093,351530..351605, 366571..366665,397465..397590,404912..405452)  
mRNA Sequence

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Length 5011  



CDS Information


   
Location 163..4623
CDS Sequence

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CCDS ID CCDS44839.1



Protein Information


      
Protein IDNP_001275701.1
Protein Namephosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Molecular Wt. (Da)122632
Protein Sequence

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Length 1445  
Uniprot IDQ13467
Ensembl Protein ID ENSP00000354607  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation419

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                  
Pathway Name Pathway ID
Inositol phosphate metabolism hsa00562
Metabolic pathways hsa01100
Phosphatidylinositol signaling system hsa04070


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd05177825-1178  PI3Kc_C2_gamma
cl21453825-1178  PKc_like superfamily
cd00869651-819  PI3Ka_II
cl00271651-819  PI3Ka superfamily
cd068961207-1307  PX_PI3K_C2_gamma
cl025631207-1307  PX_domain superfamily
cd083811329-1441  C2B_PI3K_class_II
cl146031329-1441  C2 superfamily
cd05166827-1178  PI3Kc_II
cd05176826-1178  PI3Kc_C2_alpha
cd00891827-1162  PI3Kc
cd00895826-1178  PI3Kc_C2_beta
cd05165828-1178  PI3Kc_I
cd00896829-1178  PI3Kc_III
cd05174830-1178  PI3Kc_IA_delta
cd05173875-1178  PI3Kc_IA_beta
cd00894826-1159  PI3Kc_IB_gamma
smart00146918-1132  PI3Kc
cd05175822-1178  PI3Kc_IA_alpha
cd00893902-1162  PI4Kc_III
cd05167914-1163  PI4Kc_III_alpha
pfam00454915-1129  PI3_PI4_kinase
cd05168916-1109  PI4Kc_III_beta
cd00864651-797  PI3Ka
cd068831208-1307  PX_PI3K_C2
cd00142887-1110  PI3Kc_like
smart00145669-828  PI3Ka
pfam00613663-804  PI3Ka
pfam00792506-629  PI3K_C2
cl14603506-629  C2 superfamily
cd04012520-637  C2A_PI3K_class_II
cd00872669-797  PI3Ka_I
cd05164884-1086  PIKKc
smart003121213-1304  PX
cd00870669-797  PI3Ka_III
cd05172895-1059  PIKKc_DNA-PK
cd05171900-1053  PIKKc_ATM
pfam007871207-1307  PX
cd060931204-1304  PX_domain
cd00892895-1052  PIKKc_ATR
cd040311331-1440  C2A_RIM1alpha
cd05169895-1053  PIKKc_TOR
cd072901213-1304  PX_PI3K_C2_beta
pfam00794279-369  PI3K_rbd
cl02484279-369  PI3K_rbd superfamily
cd083931332-1440  C2A_SLP-1_2
cd068861234-1303  PX_SNX27
smart002391342-1437  C2
cd13968913-1053  PKc_like
cd085211332-1440  C2A_SLP
cd040301331-1440  C2C_KIAA1228
cd05170901-1052  PIKKc_SMG1
cd068691214-1307  PX_UP2_fungi
cd040201342-1413  C2B_SLP_1-2-3-4
cd040261331-1399  C2_PKC_alpha_gamma
cd068891215-1305  PX_NoxO1
cd002761330-1437  C2B_Synaptotagmin
smart00144279-367  PI3K_rbd
pfam001681343-1419  C2
cd072891208-1304  PX_PI3K_C2_alpha
cd000301343-1440  C2
cd040281356-1444  C2B_RIM1alpha
cd086851331-1440  C2_RGS-like
cd040291332-1440  C2A_SLP-4_5
cd068851239-1306  PX_SNX17_31
cd068721208-1303  PX_SNX19_like_plant
cd068901221-1304  PX_Bem1p
cd040351365-1427  C2A_Rabphilin_Doc2
cd068821208-1304  PX_p40phox
cd068761214-1306  PX_MDM1p
cd068731215-1303  PX_SNX13
cd083921343-1440  C2A_SLP-3
cd083861331-1438  C2A_Synaptotagmin-7
smart00142474-565  PI3K_C2
COG5032876-1110  TEL1


Ontology Information


   
HPRD ID503
Molecular ClassLipid Kinase
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO