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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PIK3CB 5291 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta  3- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25776026   2015Cell line : HCT116, HT29, LoVo, LS174T

Source : Department of Colorectal Surgery, Peking University Cancer Hospital and Institute, Beijing , China and Department of Gastroenterology, Peoples Hospital, Peking University, Beijing 100044, China, ATCC

Sample Type : Rectal tumor

No. of Sample : 208

Stage : TNM Stage II,III.

Single-strand conformation polymorphism analysis, DNA sequencingFrameshift Mutation--

25473181   2014Cell line : -

Source : Department of Pathology of Binzhou Medical University Hospital.

Sample Type : CRC tumor

No. of Sample : 316

Stage : -

ImmunohistochemistryUp-regulation- Immunohistochemical staining indicated that PIK3CB was more abundant in rectal adenocarcinoma tissues .

25550888   2014Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 124

Stage : -

ImmunohistochemistryUp-regulation-The expression of both PIK3CA and PIK3CB is increased and related to the development and progress of colorectal carcinoma and MDR


Gene Details



NC_000003.11 (138371540..138553780, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]  
Chromosome 3
Location 3q22.3
Start 138371540  
End 138553780  
Strand -  
Gene Sequence

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Length 182241  
OMIM ID 602925   
HGNC ID HGNC:8976   
Unigene ID Hs.239818   
Ensembl ID ENSG00000051382   
PharmGKB ID PA33309   

mRNA Information


mRNA ID ?NM_006219.2
Exon join(75580..75766,78960..79185,92158..92381,97053..97232, 100135..100305,101501..101578,120220..120471, 122635..122731,127650..127780,130446..130496, 135844..136032,140032..140153,143796..143939, 145965..146064,150136..150314,151152..151261, 152894..152972,169736..169903,170910..171033, 177104..177249,178665..178797,179413..182241)  
mRNA Sequence

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Length 5931  



CDS Information


   
Location17..3229
CDS Sequence

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CCDS ID CCDS3104.1



Protein Information


      
Protein IDNP_006210.1
Protein Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Molecular Wt. (Da)119349
Protein Sequence

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Length 1070  
Uniprot IDQ93009
Ensembl Protein ID ENSP00000343535  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1070

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
186AGTR22071NP_000677.2in vivo11459796   
3055HCK796NP_002101.2in vitro12029088   
4311MME392NP_000893.2in vitro;in vivo12529960   
5295PIK3R11381NP_852664.1in vitro;in vivo103   589   308   139   559   
5580PRKCD1501NP_006245.2in vitro11676480   
5581PRKCE1500NP_005391.1in vivo9822674   
10971YWHAQ886NP_006817.1in vitro;in vivo7479742   


Pathway Information


                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Adrenergic signaling in cardiomyocytes hsa04261
AGE-RAGE signaling pathway in diabetic complications hsa04933
Aldosterone-regulated sodium reabsorption hsa04960
Amoebiasis hsa05146
AMPK signaling pathway hsa04152
Apoptosis hsa04210
B cell receptor signaling pathway hsa04662
Bacterial invasion of epithelial cells hsa05100
cAMP signaling pathway hsa04024
Carbohydrate digestion and absorption hsa04973
Central carbon metabolism in cancer hsa05230
cGMP-PKG signaling pathway hsa04022
Chagas disease (American trypanosomiasis) hsa05142
Chemokine signaling pathway hsa04062
Choline metabolism in cancer hsa05231
Cholinergic synapse hsa04725
Chronic myeloid leukemia hsa05220
Colorectal cancer hsa05210
Endometrial cancer hsa05213
Epstein-Barr virus infection hsa05169
ErbB signaling pathway hsa04012
Estrogen signaling pathway hsa04915
Fc epsilon RI signaling pathway hsa04664
Fc gamma R-mediated phagocytosis hsa04666
Focal adhesion hsa04510
FoxO signaling pathway hsa04068
Glioma hsa05214
Hepatitis B hsa05161
Hepatitis C hsa05160
HIF-1 signaling pathway hsa04066
HTLV-I infection hsa05166
Inflammatory mediator regulation of TRP channels hsa04750
Influenza A hsa05164
Inositol phosphate metabolism hsa00562
Insulin resistance hsa04931
Insulin signaling pathway hsa04910
Jak-STAT signaling pathway hsa04630
Leukocyte transendothelial migration hsa04670
Longevity regulating pathway - mammal hsa04211
Longevity regulating pathway - multiple species hsa04213
Measles hsa05162
Melanoma hsa05218
mTOR signaling pathway hsa04150
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Non-small cell lung cancer hsa05223
Osteoclast differentiation hsa04380
Oxytocin signaling pathway hsa04921
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Phosphatidylinositol signaling system hsa04070
Phospholipase D signaling pathway hsa04072
PI3K-Akt signaling pathway hsa04151
Platelet activation hsa04611
Progesterone-mediated oocyte maturation hsa04914
Prolactin signaling pathway hsa04917
Prostate cancer hsa05215
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Regulation of lipolysis in adipocytes hsa04923
Renal cell carcinoma hsa05211
Signaling pathways regulating pluripotency of stem cells hsa04550
Small cell lung cancer hsa05222
Sphingolipid signaling pathway hsa04071
T cell receptor signaling pathway hsa04660
Thyroid hormone signaling pathway hsa04919
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Type II diabetes mellitus hsa04930
VEGF signaling pathway hsa04370
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd05173706-1067  PI3Kc_IA_beta
cl21453706-1067  PKc_like superfamily
cd00872532-702  PI3Ka_I
cl00271532-702  PI3Ka superfamily
cd08693324-501  C2_PI3K_class_I_beta_delta
cl14603324-501  C2 superfamily
cd05165706-1066  PI3Kc_I
cd05174705-1067  PI3Kc_IA_delta
cd00891706-1050  PI3Kc
cd05166709-1064  PI3Kc_II
cd00894756-1064  PI3Kc_IB_gamma
cd05175705-1066  PI3Kc_IA_alpha
cd05176714-1064  PI3Kc_C2_alpha
pfam00613526-711  PI3Ka
smart00145538-711  PI3Ka
smart00146802-1019  PI3Kc
cd05177761-1064  PI3Kc_C2_gamma
cd00896707-1049  PI3Kc_III
pfam00454800-1017  PI3_PI4_kinase
cd00895747-1064  PI3Kc_C2_beta
cd00864538-683  PI3Ka
cd05167767-1056  PI4Kc_III_alpha
cd00893800-1056  PI4Kc_III
cd05168800-1056  PI4Kc_III_beta
cd00142770-1008  PI3Kc_like
smart00144180-288  PI3K_rbd
cl02484180-288  PI3K_rbd superfamily
pfam00794180-288  PI3K_rbd
pfam0219241-118  PI3K_p85B
cl0248341-118  PI3K_p85B superfamily
cd08380324-497  C2_PI3K_like
smart0014341-118  PI3K_p85B
cd00870538-683  PI3Ka_III
cd00869538-697  PI3Ka_II
cd05164803-1008  PIKKc
smart00142321-409  PI3K_C2
cd08398326-495  C2_PI3K_class_I_alpha
cd05171803-1003  PIKKc_ATM
pfam00792350-486  PI3K_C2
cd05172803-969  PIKKc_DNA-PK
cd00892774-996  PIKKc_ATR
cd05169767-1010  PIKKc_TOR
cd04012352-497  C2A_PI3K_class_II
cd05170896-1004  PIKKc_SMG1
cd08399326-493  C2_PI3K_class_I_gamma
cd13968799-939  PKc_like
cd08397353-462  C2_PI3K_class_III
cd05163877-961  PIKK_TRRAP
cd00871570-681  PI4Ka
COG5032707-1054  TEL1
PTZ00303808-942  PTZ00303


Ontology Information


   
HPRD ID2915
Molecular ClassLipid Kinase
Molecular FunctionTranslation regulator activity (GO:0045182)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P42338DB00201CaffeineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
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Cancer3DGO
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Tumor Gene Family of DatabasesGO
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Osteosarcoma DatabaseGO
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