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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PIK3CD 5293 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta  1p110D 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25366420   2015Cell line : SW480, CaCo 2, WiDr, HT29, LoVo, HCT116, SW620

Source : ATCC

Sample Type : CRC tumor

No. of Sample : -

Stage : TNM Stage III,IV.

 realtime RT-PCRMethylation-Microarray-based genome-wide DNA methylation analysis of 12 CRCs revealed that four ErbB-associated genes (PIK3CD, PKC?, ERBB4, ) were differentially methylated in CRCs.

23486085   2013Cell line : -

Source : -

Sample Type : CRC tumor and adjescent normal tissues.

No. of Sample : -

Stage : -

real time RT-PCR, luciferase reporter assayUp-regulation-PIK3CD downregulation inhibited cell migration and invasion, whereas PIK3CD overexpression rescued the suppressive effect of miR-30a.

24293274   2014Cell line : -

Source : Second Department of General and Oncological Surgery, Wroclaw Medical University, and from the First Department of Surgical Oncology, Lower Silesian Oncology Center, both in Wroclaw.

Sample Type : CRC tumor and adjescent normal tissues.

No. of Sample : 233

Stage : -

-Up-regulation-miR-30b in CRC and found that its expression was significantly lower in CRC tissues than that in normal tissues and functional and mechanistic links between miRNA-30b and oncogene KRAS, PIK3CD and BCL2 in the pathogenesis of CRC.


Gene Details



NC_000001.10 (9711789..9789172)

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Gene Type protein coding
Gene Family -
Description Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]  
Chromosome 1
Location 1p36.2
Start 9711789  
End 9789172  
Strand +  
Gene Sequence

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Length 77384  
OMIM ID 602839   
HGNC ID HGNC:8977   
Unigene ID Hs.518451   
Ensembl ID ENSG00000171608   
PharmGKB ID PA33310   

mRNA Information


mRNA ID ?NM_005026.3
Exon join(1..27,250..336,61579..61683,80536..80708, 85653..85881,85961..86190,86552..86731,87071..87220, 87649..87738,88806..89027,90033..90129,90224..90354, 90723..90773,90854..91021,91239..91360,91556..91699, 91873..91972,92087..92265,92356..92468,92640..92718, 93237..93404,94081..94204,94388..94533,94916..95048, 97021..99037)  
mRNA Sequence

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Length 5265  



CDS Information


   
Location252..3386
CDS Sequence

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CCDS ID CCDS104.1



Protein Information


      
Protein IDNP_005017.3
Protein Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Molecular Wt. (Da)126323
Protein Sequence

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Length 1044  
Uniprot IDP35659
Ensembl Protein ID ENSP00000244776  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1063
SPhosphorylation1039

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3265HRAS1813NP_005334.1in vivo1   173   952   391   139   890   000   000   
3266ERAS2339NP_853510.1in vivo12774123   
3562IL3987NP_000579.2in vivo9113989   
3565IL4989NP_000580.1in vivo9113989   
4254KITLG1698NP_000890.1in vivo9113989   
5295PIK3R11381NP_852664.1in vivo9113989   
22913RALY11480NP_057951.1yeast 2-hybrid16169070   
30000TNPO24301NP_001129668.1yeast 2-hybrid16169070   
84164ASCC216515NP_115580.2yeast 2-hybrid16169070   
84331FAM195A17503NP_612427.2yeast 2-hybrid16169070   


Pathway Information


                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Adrenergic signaling in cardiomyocytes hsa04261
AGE-RAGE signaling pathway in diabetic complications hsa04933
Aldosterone-regulated sodium reabsorption hsa04960
Amoebiasis hsa05146
AMPK signaling pathway hsa04152
Apoptosis hsa04210
B cell receptor signaling pathway hsa04662
Bacterial invasion of epithelial cells hsa05100
cAMP signaling pathway hsa04024
Carbohydrate digestion and absorption hsa04973
Central carbon metabolism in cancer hsa05230
cGMP-PKG signaling pathway hsa04022
Chagas disease (American trypanosomiasis) hsa05142
Chemokine signaling pathway hsa04062
Choline metabolism in cancer hsa05231
Cholinergic synapse hsa04725
Chronic myeloid leukemia hsa05220
Colorectal cancer hsa05210
Endometrial cancer hsa05213
Epstein-Barr virus infection hsa05169
ErbB signaling pathway hsa04012
Estrogen signaling pathway hsa04915
Fc epsilon RI signaling pathway hsa04664
Fc gamma R-mediated phagocytosis hsa04666
Focal adhesion hsa04510
FoxO signaling pathway hsa04068
Glioma hsa05214
Hepatitis B hsa05161
Hepatitis C hsa05160
HIF-1 signaling pathway hsa04066
HTLV-I infection hsa05166
Inflammatory mediator regulation of TRP channels hsa04750
Influenza A hsa05164
Inositol phosphate metabolism hsa00562
Insulin resistance hsa04931
Insulin signaling pathway hsa04910
Jak-STAT signaling pathway hsa04630
Leukocyte transendothelial migration hsa04670
Longevity regulating pathway - mammal hsa04211
Longevity regulating pathway - multiple species hsa04213
Measles hsa05162
Melanoma hsa05218
mTOR signaling pathway hsa04150
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Non-small cell lung cancer hsa05223
Osteoclast differentiation hsa04380
Oxytocin signaling pathway hsa04921
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Phosphatidylinositol signaling system hsa04070
Phospholipase D signaling pathway hsa04072
PI3K-Akt signaling pathway hsa04151
Platelet activation hsa04611
Progesterone-mediated oocyte maturation hsa04914
Prolactin signaling pathway hsa04917
Prostate cancer hsa05215
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Regulation of lipolysis in adipocytes hsa04923
Renal cell carcinoma hsa05211
Signaling pathways regulating pluripotency of stem cells hsa04550
Small cell lung cancer hsa05222
Sphingolipid signaling pathway hsa04071
T cell receptor signaling pathway hsa04660
Thyroid hormone signaling pathway hsa04919
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Type II diabetes mellitus hsa04930
VEGF signaling pathway hsa04370
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd05174676-1042  PI3Kc_IA_delta
cl21453676-1042  PKc_like superfamily
cd08693314-481  C2_PI3K_class_I_beta_delta
cl14603314-481  C2 superfamily
cd05165679-1040  PI3Kc_I
cd05173679-1041  PI3Kc_IA_beta
cd00891679-1024  PI3Kc
cd05166682-1038  PI3Kc_II
cd05175678-1040  PI3Kc_IA_alpha
cd00894729-1038  PI3Kc_IB_gamma
cd05176720-1040  PI3Kc_C2_alpha
smart00145503-684  PI3Ka
cl00271503-684  PI3Ka superfamily
cd00896680-1023  PI3Kc_III
smart00146776-993  PI3Kc
cd05177734-1040  PI3Kc_C2_gamma
cd00872505-675  PI3Ka_I
cd00895734-1040  PI3Kc_C2_beta
pfam00454774-990  PI3_PI4_kinase
pfam00613503-684  PI3Ka
cd00864506-656  PI3Ka
cd05167777-1030  PI4Kc_III_alpha
cd00893774-1030  PI4Kc_III
cd05168774-1030  PI4Kc_III_beta
cd00142746-981  PI3Kc_like
cd08380314-478  C2_PI3K_like
pfam0219231-108  PI3K_p85B
cl0248331-108  PI3K_p85B superfamily
pfam00794175-281  PI3K_rbd
cl02484175-281  PI3K_rbd superfamily
cd08398315-467  C2_PI3K_class_I_alpha
pfam00792339-466  PI3K_C2
cd00870504-656  PI3Ka_III
cd00869505-656  PI3Ka_II
smart00142312-407  PI3K_C2
cd05164752-971  PIKKc
smart0014331-108  PI3K_p85B
cd05172777-943  PIKKc_DNA-PK
cd05169752-971  PIKKc_TOR
cd05171772-970  PIKKc_ATM
smart00144183-281  PI3K_rbd
cd08399313-483  C2_PI3K_class_I_gamma
cd00892752-970  PIKKc_ATR
cd04012345-479  C2A_PI3K_class_II
cd05170858-978  PIKKc_SMG1
cd13968769-913  PKc_like
cd00871541-655  PI4Ka
cd08397370-461  C2_PI3K_class_III
cd05163874-935  PIKK_TRRAP
COG5032634-1015  TEL1
PTZ00303782-912  PTZ00303


Ontology Information


   
HPRD ID5849
Molecular ClassLipid Kinase
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
O00329DB00201CaffeineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO