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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PIK3CG 5294 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma  7- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
12473596   2002Cell line : DLD 1, LoVo, Colo205, HCT 15, SW480

Source : Yamagata University Hospital (Yamagata, Japan)

Sample Type : Formalin-fixed and paraffin-embedded tumors

No. of Sample : 68

Stage : -

real time RT-PCR, Western blotting,immunohistochemistryDown-regulation/Hypermethylation-Reduction of PIK3CG expression was detected immunohistochemically in 85% of human colorectal cancers and was closely associated with invasion, metastasis, and poor differentiation and hypermethylation of promoter regions were also detected in primary colon cancers.


Gene Details



NC_000007.13 (106505723..106547592)

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Gene Type protein coding
Gene Family -
Description Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]  
Chromosome 7
Location 7q22
Start 106505723  
End 106547592  
Strand +  
Gene Sequence

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Length 41870  
OMIM ID 601232   
HGNC ID HGNC:8978   
Unigene ID Hs.32942   
Ensembl ID ENSG00000105851   
PharmGKB ID PA33311   

mRNA Information


mRNA ID ?NM_001282426.1
Exon join(1..149,2273..4279,7260..7325,7436..7661,9423..9526, 14242..14388,16840..16930,17756..17886,18878..18989, 20858..21015,39832..43701)  
mRNA Sequence

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Length 7069  



CDS Information


   
Location162..3470
CDS Sequence

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CCDS ID CCDS5739.1



Protein Information


      
Protein IDNP_001269355.1
Protein Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Molecular Wt. (Da)81494
Protein Sequence

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Length 1102  
Uniprot IDQ13155
Ensembl Protein ID ENSP00000223029  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1101

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
156ADRBK1182NP_001610.2in vivo12163475   
2046EPHA81493NP_065387.1in vitro;in vivo11416136   
2549GAB15116NP_997006.1yeast 2-hybrid10871282   
2934GSN674NP_000168.1in vitro;in vivo11577104   
3265HRAS1813NP_005334.1in vitro11136978   
3572IL6ST2824NP_002175.2in vivo10579793   
3845KRAS1817NP_203524.1in vivo10542052   
4067LYN1301NP_002341.1in vivo10318860   
4851NOTCH11827NP_060087.3in vivo14583609   
7169TPM211768NP_003280.2in vitro;in vivo16094730   


Pathway Information


                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Adrenergic signaling in cardiomyocytes hsa04261
AGE-RAGE signaling pathway in diabetic complications hsa04933
Aldosterone-regulated sodium reabsorption hsa04960
Amoebiasis hsa05146
AMPK signaling pathway hsa04152
Apoptosis hsa04210
B cell receptor signaling pathway hsa04662
Bacterial invasion of epithelial cells hsa05100
cAMP signaling pathway hsa04024
Carbohydrate digestion and absorption hsa04973
Central carbon metabolism in cancer hsa05230
cGMP-PKG signaling pathway hsa04022
Chagas disease (American trypanosomiasis) hsa05142
Chemokine signaling pathway hsa04062
Choline metabolism in cancer hsa05231
Cholinergic synapse hsa04725
Chronic myeloid leukemia hsa05220
Colorectal cancer hsa05210
Endometrial cancer hsa05213
Epstein-Barr virus infection hsa05169
ErbB signaling pathway hsa04012
Estrogen signaling pathway hsa04915
Fc epsilon RI signaling pathway hsa04664
Fc gamma R-mediated phagocytosis hsa04666
Focal adhesion hsa04510
FoxO signaling pathway hsa04068
Glioma hsa05214
Hepatitis B hsa05161
Hepatitis C hsa05160
HIF-1 signaling pathway hsa04066
HTLV-I infection hsa05166
Inflammatory mediator regulation of TRP channels hsa04750
Influenza A hsa05164
Inositol phosphate metabolism hsa00562
Insulin resistance hsa04931
Insulin signaling pathway hsa04910
Jak-STAT signaling pathway hsa04630
Leukocyte transendothelial migration hsa04670
Longevity regulating pathway - mammal hsa04211
Longevity regulating pathway - multiple species hsa04213
Measles hsa05162
Melanoma hsa05218
mTOR signaling pathway hsa04150
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Non-small cell lung cancer hsa05223
Osteoclast differentiation hsa04380
Oxytocin signaling pathway hsa04921
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Phosphatidylinositol signaling system hsa04070
Phospholipase D signaling pathway hsa04072
PI3K-Akt signaling pathway hsa04151
Platelet activation hsa04611
Progesterone-mediated oocyte maturation hsa04914
Prolactin signaling pathway hsa04917
Prostate cancer hsa05215
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Regulation of lipolysis in adipocytes hsa04923
Renal cell carcinoma hsa05211
Signaling pathways regulating pluripotency of stem cells hsa04550
Small cell lung cancer hsa05222
Sphingolipid signaling pathway hsa04071
T cell receptor signaling pathway hsa04660
Thyroid hormone signaling pathway hsa04919
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Type II diabetes mellitus hsa04930
VEGF signaling pathway hsa04370
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00894729-1095  PI3Kc_IB_gamma
cl21453729-1095  PKc_like superfamily
cd08399350-527  C2_PI3K_class_I_gamma
cl14603350-527  C2 superfamily
cd00872549-725  PI3Ka_I
cl00271549-725  PI3Ka superfamily
cd05165729-1091  PI3Kc_I
cd00891730-1077  PI3Kc
cd05166730-1089  PI3Kc_II
cd05173732-1091  PI3Kc_IA_beta
cd05174786-1091  PI3Kc_IA_delta
cd05175724-1091  PI3Kc_IA_alpha
cd05176731-1089  PI3Kc_C2_alpha
cd05177731-1073  PI3Kc_C2_gamma
smart00146830-1046  PI3Kc
cd00895731-1089  PI3Kc_C2_beta
cd00142794-1037  PI3Kc_like
cd00896734-1073  PI3Kc_III
pfam00613543-733  PI3Ka
smart00145545-732  PI3Ka
pfam00454828-1044  PI3_PI4_kinase
cd05167799-1095  PI4Kc_III_alpha
cd00864549-703  PI3Ka
cd00893830-1094  PI4Kc_III
cd05168828-1094  PI4Kc_III_beta
cd08380352-527  C2_PI3K_like
smart00144203-312  PI3K_rbd
cl02484203-312  PI3K_rbd superfamily
cd00870548-703  PI3Ka_III
cd00869553-719  PI3Ka_II
pfam00794203-312  PI3K_rbd
cd05164802-1035  PIKKc
smart00142349-444  PI3K_C2
cd05172803-1028  PIKKc_DNA-PK
pfam00792377-503  PI3K_C2
cd13968808-966  PKc_like
cd00892799-1034  PIKKc_ATR
cd08693352-523  C2_PI3K_class_I_beta_delta
cd05171831-1030  PIKKc_ATM
cd05169802-988  PIKKc_TOR
cd05170832-1033  PIKKc_SMG1
cd04012382-485  C2A_PI3K_class_II
cd08398353-527  C2_PI3K_class_I_alpha
cd08397375-434  C2_PI3K_class_III
cd05163891-999  PIKK_TRRAP
COG5032739-1085  TEL1
PTZ00303844-976  PTZ00303


Ontology Information


   
HPRD ID8962
Molecular ClassLipid Kinase
Molecular FunctionProtease inhibitor activity (GO:0030414)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO